Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock

Detalhes bibliográficos
Autor(a) principal: Resende, Tatiana P.
Data de Publicação: 2014
Outros Autores: Andrade, Raquel P., Palmeirim, Isabel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/12043
Resumo: All vertebrate species present a segmented body, easily observed in the vertebrate column and its associated components, which provides a high degree of motility to the adult body and efficient protection of the internal organs. The sequential formation of the segmented precursors of the vertebral column during embryonic development, the somites, is governed by an oscillating genetic network, the somitogenesis molecular clock. Herein, we provide an overview of the molecular clock operating during somite formation and its underlying molecular regulatory mechanisms. Human congenital vertebral malformations have been associated with perturbations in these oscillatory mechanisms. Thus, a better comprehension of the molecular mechanisms regulating somite formation is required in order to fully understand the origin of human skeletal malformations.
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spelling Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clockPresomitic mesoderm cellsSomite boundary formationNegative feedback loopLunatic-fringeChick-embryoAvian embryosPrimitive streakGene-expressionMouse embryosOscillatory expressionAll vertebrate species present a segmented body, easily observed in the vertebrate column and its associated components, which provides a high degree of motility to the adult body and efficient protection of the internal organs. The sequential formation of the segmented precursors of the vertebral column during embryonic development, the somites, is governed by an oscillating genetic network, the somitogenesis molecular clock. Herein, we provide an overview of the molecular clock operating during somite formation and its underlying molecular regulatory mechanisms. Human congenital vertebral malformations have been associated with perturbations in these oscillatory mechanisms. Thus, a better comprehension of the molecular mechanisms regulating somite formation is required in order to fully understand the origin of human skeletal malformations.Hindawi LtdSapientiaResende, Tatiana P.Andrade, Raquel P.Palmeirim, Isabel2018-12-07T14:58:28Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/12043eng2314-61332314-614110.1155/2014/718683info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-29T10:57:59Zoai:sapientia.ualg.pt:10400.1/12043Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-29T10:57:59Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock
title Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock
spellingShingle Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock
Resende, Tatiana P.
Presomitic mesoderm cells
Somite boundary formation
Negative feedback loop
Lunatic-fringe
Chick-embryo
Avian embryos
Primitive streak
Gene-expression
Mouse embryos
Oscillatory expression
title_short Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock
title_full Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock
title_fullStr Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock
title_full_unstemmed Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock
title_sort Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock
author Resende, Tatiana P.
author_facet Resende, Tatiana P.
Andrade, Raquel P.
Palmeirim, Isabel
author_role author
author2 Andrade, Raquel P.
Palmeirim, Isabel
author2_role author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Resende, Tatiana P.
Andrade, Raquel P.
Palmeirim, Isabel
dc.subject.por.fl_str_mv Presomitic mesoderm cells
Somite boundary formation
Negative feedback loop
Lunatic-fringe
Chick-embryo
Avian embryos
Primitive streak
Gene-expression
Mouse embryos
Oscillatory expression
topic Presomitic mesoderm cells
Somite boundary formation
Negative feedback loop
Lunatic-fringe
Chick-embryo
Avian embryos
Primitive streak
Gene-expression
Mouse embryos
Oscillatory expression
description All vertebrate species present a segmented body, easily observed in the vertebrate column and its associated components, which provides a high degree of motility to the adult body and efficient protection of the internal organs. The sequential formation of the segmented precursors of the vertebral column during embryonic development, the somites, is governed by an oscillating genetic network, the somitogenesis molecular clock. Herein, we provide an overview of the molecular clock operating during somite formation and its underlying molecular regulatory mechanisms. Human congenital vertebral malformations have been associated with perturbations in these oscillatory mechanisms. Thus, a better comprehension of the molecular mechanisms regulating somite formation is required in order to fully understand the origin of human skeletal malformations.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
2018-12-07T14:58:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/12043
url http://hdl.handle.net/10400.1/12043
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2314-6133
2314-6141
10.1155/2014/718683
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi Ltd
publisher.none.fl_str_mv Hindawi Ltd
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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