Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/106873 https://doi.org/10.1016/j.dib.2019.104548 |
Resumo: | This dataset is related to the research article entitled "May iron(III) complexes containing phenanthroline derivatives as ligands be prospective anticancer agents?" [1]. It includes the characterization by UV-Vis absorption spectroscopy and magnetic techniques of a group of mixed ligand Fe(III) complexes bearing a tripodal aminophenolate ligand L2-, H2L = N,N-bis(2-hydroxy-3,5-dimethylbenzyl)-N-(2-pyridylmethyl)amine, and different aromatic bases (NN = 2,2'-bipyridine [Fe(L)(bipy)]PF6 (1), 1,10-phenanthroline [Fe(L)(phen)]PF6 (2), or a phenanthroline derivative co-ligand: [Fe(L)(amphen)]NO3 (3), [Fe(L)(amphen)]PF6 (3a), [Fe(L)(Clphen)]PF6 (4), [Fe(L)(epoxyphen)]PF6 (5) (where amphen = 1,10-phenanthroline-5-amine, epoxyphen = 5,6-epoxy-5,6-dihydro-1,10-phenanthroline, Clphen = 5-chloro-1,10-phenanthroline), as well as [Fe(L)(EtOH)]NO3 (6), [Fe(phen)Cl3] (7) and [Fe(amphen)Cl3] (8). Data on their hydrolytic stability in physiological buffers is shown, as well as on their interaction with calf thymus DNA by spectroscopic tools. Additionally, the anticancer efficacy and the cellular death mechanisms activated in response to these drugs in HeLa, H1299 and MDA-MB-231 cells are provided. |
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Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer propertiesFe(III) complexesPhenanthrolineAnticancerCytotoxicityGenotoxicityThis dataset is related to the research article entitled "May iron(III) complexes containing phenanthroline derivatives as ligands be prospective anticancer agents?" [1]. It includes the characterization by UV-Vis absorption spectroscopy and magnetic techniques of a group of mixed ligand Fe(III) complexes bearing a tripodal aminophenolate ligand L2-, H2L = N,N-bis(2-hydroxy-3,5-dimethylbenzyl)-N-(2-pyridylmethyl)amine, and different aromatic bases (NN = 2,2'-bipyridine [Fe(L)(bipy)]PF6 (1), 1,10-phenanthroline [Fe(L)(phen)]PF6 (2), or a phenanthroline derivative co-ligand: [Fe(L)(amphen)]NO3 (3), [Fe(L)(amphen)]PF6 (3a), [Fe(L)(Clphen)]PF6 (4), [Fe(L)(epoxyphen)]PF6 (5) (where amphen = 1,10-phenanthroline-5-amine, epoxyphen = 5,6-epoxy-5,6-dihydro-1,10-phenanthroline, Clphen = 5-chloro-1,10-phenanthroline), as well as [Fe(L)(EtOH)]NO3 (6), [Fe(phen)Cl3] (7) and [Fe(amphen)Cl3] (8). Data on their hydrolytic stability in physiological buffers is shown, as well as on their interaction with calf thymus DNA by spectroscopic tools. Additionally, the anticancer efficacy and the cellular death mechanisms activated in response to these drugs in HeLa, H1299 and MDA-MB-231 cells are provided.Elsevier2019-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106873http://hdl.handle.net/10316/106873https://doi.org/10.1016/j.dib.2019.104548eng23523409Matos, Cristina PAdiguzel, ZelalYildizhan, YaseminCevatemre, BuseBagci-Onder, TugbaCevik, OzgeNunes, PatriqueFerreira, Liliana P.Carvalho, Maria DeusCampos, Débora LPavan, Fernando RPessoa, João CostaGarcia, Maria HelenaTomaz, Ana IsabelCorreia, IsabelAcilan, Ceydainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-28T08:52:33Zoai:estudogeral.uc.pt:10316/106873Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:16.525108Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties |
title |
Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties |
spellingShingle |
Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties Matos, Cristina P Fe(III) complexes Phenanthroline Anticancer Cytotoxicity Genotoxicity |
title_short |
Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties |
title_full |
Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties |
title_fullStr |
Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties |
title_full_unstemmed |
Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties |
title_sort |
Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties |
author |
Matos, Cristina P |
author_facet |
Matos, Cristina P Adiguzel, Zelal Yildizhan, Yasemin Cevatemre, Buse Bagci-Onder, Tugba Cevik, Ozge Nunes, Patrique Ferreira, Liliana P. Carvalho, Maria Deus Campos, Débora L Pavan, Fernando R Pessoa, João Costa Garcia, Maria Helena Tomaz, Ana Isabel Correia, Isabel Acilan, Ceyda |
author_role |
author |
author2 |
Adiguzel, Zelal Yildizhan, Yasemin Cevatemre, Buse Bagci-Onder, Tugba Cevik, Ozge Nunes, Patrique Ferreira, Liliana P. Carvalho, Maria Deus Campos, Débora L Pavan, Fernando R Pessoa, João Costa Garcia, Maria Helena Tomaz, Ana Isabel Correia, Isabel Acilan, Ceyda |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Matos, Cristina P Adiguzel, Zelal Yildizhan, Yasemin Cevatemre, Buse Bagci-Onder, Tugba Cevik, Ozge Nunes, Patrique Ferreira, Liliana P. Carvalho, Maria Deus Campos, Débora L Pavan, Fernando R Pessoa, João Costa Garcia, Maria Helena Tomaz, Ana Isabel Correia, Isabel Acilan, Ceyda |
dc.subject.por.fl_str_mv |
Fe(III) complexes Phenanthroline Anticancer Cytotoxicity Genotoxicity |
topic |
Fe(III) complexes Phenanthroline Anticancer Cytotoxicity Genotoxicity |
description |
This dataset is related to the research article entitled "May iron(III) complexes containing phenanthroline derivatives as ligands be prospective anticancer agents?" [1]. It includes the characterization by UV-Vis absorption spectroscopy and magnetic techniques of a group of mixed ligand Fe(III) complexes bearing a tripodal aminophenolate ligand L2-, H2L = N,N-bis(2-hydroxy-3,5-dimethylbenzyl)-N-(2-pyridylmethyl)amine, and different aromatic bases (NN = 2,2'-bipyridine [Fe(L)(bipy)]PF6 (1), 1,10-phenanthroline [Fe(L)(phen)]PF6 (2), or a phenanthroline derivative co-ligand: [Fe(L)(amphen)]NO3 (3), [Fe(L)(amphen)]PF6 (3a), [Fe(L)(Clphen)]PF6 (4), [Fe(L)(epoxyphen)]PF6 (5) (where amphen = 1,10-phenanthroline-5-amine, epoxyphen = 5,6-epoxy-5,6-dihydro-1,10-phenanthroline, Clphen = 5-chloro-1,10-phenanthroline), as well as [Fe(L)(EtOH)]NO3 (6), [Fe(phen)Cl3] (7) and [Fe(amphen)Cl3] (8). Data on their hydrolytic stability in physiological buffers is shown, as well as on their interaction with calf thymus DNA by spectroscopic tools. Additionally, the anticancer efficacy and the cellular death mechanisms activated in response to these drugs in HeLa, H1299 and MDA-MB-231 cells are provided. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/106873 http://hdl.handle.net/10316/106873 https://doi.org/10.1016/j.dib.2019.104548 |
url |
http://hdl.handle.net/10316/106873 https://doi.org/10.1016/j.dib.2019.104548 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
23523409 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134120210595840 |