Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties

Detalhes bibliográficos
Autor(a) principal: Matos, Cristina P
Data de Publicação: 2019
Outros Autores: Adiguzel, Zelal, Yildizhan, Yasemin, Cevatemre, Buse, Bagci-Onder, Tugba, Cevik, Ozge, Nunes, Patrique, Ferreira, Liliana P., Carvalho, Maria Deus, Campos, Débora L, Pavan, Fernando R, Pessoa, João Costa, Garcia, Maria Helena, Tomaz, Ana Isabel, Correia, Isabel, Acilan, Ceyda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/106873
https://doi.org/10.1016/j.dib.2019.104548
Resumo: This dataset is related to the research article entitled "May iron(III) complexes containing phenanthroline derivatives as ligands be prospective anticancer agents?" [1]. It includes the characterization by UV-Vis absorption spectroscopy and magnetic techniques of a group of mixed ligand Fe(III) complexes bearing a tripodal aminophenolate ligand L2-, H2L = N,N-bis(2-hydroxy-3,5-dimethylbenzyl)-N-(2-pyridylmethyl)amine, and different aromatic bases (NN = 2,2'-bipyridine [Fe(L)(bipy)]PF6 (1), 1,10-phenanthroline [Fe(L)(phen)]PF6 (2), or a phenanthroline derivative co-ligand: [Fe(L)(amphen)]NO3 (3), [Fe(L)(amphen)]PF6 (3a), [Fe(L)(Clphen)]PF6 (4), [Fe(L)(epoxyphen)]PF6 (5) (where amphen = 1,10-phenanthroline-5-amine, epoxyphen = 5,6-epoxy-5,6-dihydro-1,10-phenanthroline, Clphen = 5-chloro-1,10-phenanthroline), as well as [Fe(L)(EtOH)]NO3 (6), [Fe(phen)Cl3] (7) and [Fe(amphen)Cl3] (8). Data on their hydrolytic stability in physiological buffers is shown, as well as on their interaction with calf thymus DNA by spectroscopic tools. Additionally, the anticancer efficacy and the cellular death mechanisms activated in response to these drugs in HeLa, H1299 and MDA-MB-231 cells are provided.
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spelling Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer propertiesFe(III) complexesPhenanthrolineAnticancerCytotoxicityGenotoxicityThis dataset is related to the research article entitled "May iron(III) complexes containing phenanthroline derivatives as ligands be prospective anticancer agents?" [1]. It includes the characterization by UV-Vis absorption spectroscopy and magnetic techniques of a group of mixed ligand Fe(III) complexes bearing a tripodal aminophenolate ligand L2-, H2L = N,N-bis(2-hydroxy-3,5-dimethylbenzyl)-N-(2-pyridylmethyl)amine, and different aromatic bases (NN = 2,2'-bipyridine [Fe(L)(bipy)]PF6 (1), 1,10-phenanthroline [Fe(L)(phen)]PF6 (2), or a phenanthroline derivative co-ligand: [Fe(L)(amphen)]NO3 (3), [Fe(L)(amphen)]PF6 (3a), [Fe(L)(Clphen)]PF6 (4), [Fe(L)(epoxyphen)]PF6 (5) (where amphen = 1,10-phenanthroline-5-amine, epoxyphen = 5,6-epoxy-5,6-dihydro-1,10-phenanthroline, Clphen = 5-chloro-1,10-phenanthroline), as well as [Fe(L)(EtOH)]NO3 (6), [Fe(phen)Cl3] (7) and [Fe(amphen)Cl3] (8). Data on their hydrolytic stability in physiological buffers is shown, as well as on their interaction with calf thymus DNA by spectroscopic tools. Additionally, the anticancer efficacy and the cellular death mechanisms activated in response to these drugs in HeLa, H1299 and MDA-MB-231 cells are provided.Elsevier2019-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106873http://hdl.handle.net/10316/106873https://doi.org/10.1016/j.dib.2019.104548eng23523409Matos, Cristina PAdiguzel, ZelalYildizhan, YaseminCevatemre, BuseBagci-Onder, TugbaCevik, OzgeNunes, PatriqueFerreira, Liliana P.Carvalho, Maria DeusCampos, Débora LPavan, Fernando RPessoa, João CostaGarcia, Maria HelenaTomaz, Ana IsabelCorreia, IsabelAcilan, Ceydainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-28T08:52:33Zoai:estudogeral.uc.pt:10316/106873Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:16.525108Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties
title Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties
spellingShingle Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties
Matos, Cristina P
Fe(III) complexes
Phenanthroline
Anticancer
Cytotoxicity
Genotoxicity
title_short Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties
title_full Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties
title_fullStr Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties
title_full_unstemmed Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties
title_sort Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties
author Matos, Cristina P
author_facet Matos, Cristina P
Adiguzel, Zelal
Yildizhan, Yasemin
Cevatemre, Buse
Bagci-Onder, Tugba
Cevik, Ozge
Nunes, Patrique
Ferreira, Liliana P.
Carvalho, Maria Deus
Campos, Débora L
Pavan, Fernando R
Pessoa, João Costa
Garcia, Maria Helena
Tomaz, Ana Isabel
Correia, Isabel
Acilan, Ceyda
author_role author
author2 Adiguzel, Zelal
Yildizhan, Yasemin
Cevatemre, Buse
Bagci-Onder, Tugba
Cevik, Ozge
Nunes, Patrique
Ferreira, Liliana P.
Carvalho, Maria Deus
Campos, Débora L
Pavan, Fernando R
Pessoa, João Costa
Garcia, Maria Helena
Tomaz, Ana Isabel
Correia, Isabel
Acilan, Ceyda
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Matos, Cristina P
Adiguzel, Zelal
Yildizhan, Yasemin
Cevatemre, Buse
Bagci-Onder, Tugba
Cevik, Ozge
Nunes, Patrique
Ferreira, Liliana P.
Carvalho, Maria Deus
Campos, Débora L
Pavan, Fernando R
Pessoa, João Costa
Garcia, Maria Helena
Tomaz, Ana Isabel
Correia, Isabel
Acilan, Ceyda
dc.subject.por.fl_str_mv Fe(III) complexes
Phenanthroline
Anticancer
Cytotoxicity
Genotoxicity
topic Fe(III) complexes
Phenanthroline
Anticancer
Cytotoxicity
Genotoxicity
description This dataset is related to the research article entitled "May iron(III) complexes containing phenanthroline derivatives as ligands be prospective anticancer agents?" [1]. It includes the characterization by UV-Vis absorption spectroscopy and magnetic techniques of a group of mixed ligand Fe(III) complexes bearing a tripodal aminophenolate ligand L2-, H2L = N,N-bis(2-hydroxy-3,5-dimethylbenzyl)-N-(2-pyridylmethyl)amine, and different aromatic bases (NN = 2,2'-bipyridine [Fe(L)(bipy)]PF6 (1), 1,10-phenanthroline [Fe(L)(phen)]PF6 (2), or a phenanthroline derivative co-ligand: [Fe(L)(amphen)]NO3 (3), [Fe(L)(amphen)]PF6 (3a), [Fe(L)(Clphen)]PF6 (4), [Fe(L)(epoxyphen)]PF6 (5) (where amphen = 1,10-phenanthroline-5-amine, epoxyphen = 5,6-epoxy-5,6-dihydro-1,10-phenanthroline, Clphen = 5-chloro-1,10-phenanthroline), as well as [Fe(L)(EtOH)]NO3 (6), [Fe(phen)Cl3] (7) and [Fe(amphen)Cl3] (8). Data on their hydrolytic stability in physiological buffers is shown, as well as on their interaction with calf thymus DNA by spectroscopic tools. Additionally, the anticancer efficacy and the cellular death mechanisms activated in response to these drugs in HeLa, H1299 and MDA-MB-231 cells are provided.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/106873
http://hdl.handle.net/10316/106873
https://doi.org/10.1016/j.dib.2019.104548
url http://hdl.handle.net/10316/106873
https://doi.org/10.1016/j.dib.2019.104548
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 23523409
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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