COMPOSTOS QUIMIOTERÁPICOS DE OURO: UMA VISÃO GERAL DOS COMPLEXOS ANTICÂNCER DE Au(I/III) EM RELAÇÃO À ESTRUTURA DO LIGANTE
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000801104 |
Resumo: | Gold compounds engage an important place in the field of medicinal chemistry due to their therapeutic properties. Since the last four decades, Au(I) and Au(III) complexes have attracted the attention of researchers due to their anti-tumor proprieties and the different mechanisms of action they display in comparison to conventional anticancer platinum compounds. Au(I/III) complexes can inhibit the activity of enzymes containing thiols including thioredoxin reductase; nevertheless, the affinity for several therapeutic targets has been confirmed in recent years. The properties conferred by auxiliary ligands such as phosphines (PR3) and N-heterocyclic carbenes (NHCs) to gold complexes have been key to the development of more promising anticancer compounds. In the same way, it has happened with the inclusion of some multidentate ligands in Au(III) complexes, increasing their stability and selectivity for tumor cells. In this review, we discuss the anticancer effects of Au(I) complexes containing PR3 and NHCs ligands as well as Au(III) complexes containing multidentate ligands especially those that have high cytotoxicity and information on the mechanism of action, as well as attempts to target identification and validation. |
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COMPOSTOS QUIMIOTERÁPICOS DE OURO: UMA VISÃO GERAL DOS COMPLEXOS ANTICÂNCER DE Au(I/III) EM RELAÇÃO À ESTRUTURA DO LIGANTEAu(I) complexesAu(III) complexesanticancer activityphosphinesN-heterocyclic carbenesGold compounds engage an important place in the field of medicinal chemistry due to their therapeutic properties. Since the last four decades, Au(I) and Au(III) complexes have attracted the attention of researchers due to their anti-tumor proprieties and the different mechanisms of action they display in comparison to conventional anticancer platinum compounds. Au(I/III) complexes can inhibit the activity of enzymes containing thiols including thioredoxin reductase; nevertheless, the affinity for several therapeutic targets has been confirmed in recent years. The properties conferred by auxiliary ligands such as phosphines (PR3) and N-heterocyclic carbenes (NHCs) to gold complexes have been key to the development of more promising anticancer compounds. In the same way, it has happened with the inclusion of some multidentate ligands in Au(III) complexes, increasing their stability and selectivity for tumor cells. In this review, we discuss the anticancer effects of Au(I) complexes containing PR3 and NHCs ligands as well as Au(III) complexes containing multidentate ligands especially those that have high cytotoxicity and information on the mechanism of action, as well as attempts to target identification and validation.Sociedade Brasileira de Química2020-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000801104Química Nova v.43 n.8 2020reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170566info:eu-repo/semantics/openAccessDelgado,Giset Y. SánchezCondé,Camila A. S. R.Santos,Hélio F. DosNavarro,Maribelpor2020-10-13T00:00:00Zoai:scielo:S0100-40422020000801104Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2020-10-13T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
COMPOSTOS QUIMIOTERÁPICOS DE OURO: UMA VISÃO GERAL DOS COMPLEXOS ANTICÂNCER DE Au(I/III) EM RELAÇÃO À ESTRUTURA DO LIGANTE |
title |
COMPOSTOS QUIMIOTERÁPICOS DE OURO: UMA VISÃO GERAL DOS COMPLEXOS ANTICÂNCER DE Au(I/III) EM RELAÇÃO À ESTRUTURA DO LIGANTE |
spellingShingle |
COMPOSTOS QUIMIOTERÁPICOS DE OURO: UMA VISÃO GERAL DOS COMPLEXOS ANTICÂNCER DE Au(I/III) EM RELAÇÃO À ESTRUTURA DO LIGANTE Delgado,Giset Y. Sánchez Au(I) complexes Au(III) complexes anticancer activity phosphines N-heterocyclic carbenes |
title_short |
COMPOSTOS QUIMIOTERÁPICOS DE OURO: UMA VISÃO GERAL DOS COMPLEXOS ANTICÂNCER DE Au(I/III) EM RELAÇÃO À ESTRUTURA DO LIGANTE |
title_full |
COMPOSTOS QUIMIOTERÁPICOS DE OURO: UMA VISÃO GERAL DOS COMPLEXOS ANTICÂNCER DE Au(I/III) EM RELAÇÃO À ESTRUTURA DO LIGANTE |
title_fullStr |
COMPOSTOS QUIMIOTERÁPICOS DE OURO: UMA VISÃO GERAL DOS COMPLEXOS ANTICÂNCER DE Au(I/III) EM RELAÇÃO À ESTRUTURA DO LIGANTE |
title_full_unstemmed |
COMPOSTOS QUIMIOTERÁPICOS DE OURO: UMA VISÃO GERAL DOS COMPLEXOS ANTICÂNCER DE Au(I/III) EM RELAÇÃO À ESTRUTURA DO LIGANTE |
title_sort |
COMPOSTOS QUIMIOTERÁPICOS DE OURO: UMA VISÃO GERAL DOS COMPLEXOS ANTICÂNCER DE Au(I/III) EM RELAÇÃO À ESTRUTURA DO LIGANTE |
author |
Delgado,Giset Y. Sánchez |
author_facet |
Delgado,Giset Y. Sánchez Condé,Camila A. S. R. Santos,Hélio F. Dos Navarro,Maribel |
author_role |
author |
author2 |
Condé,Camila A. S. R. Santos,Hélio F. Dos Navarro,Maribel |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Delgado,Giset Y. Sánchez Condé,Camila A. S. R. Santos,Hélio F. Dos Navarro,Maribel |
dc.subject.por.fl_str_mv |
Au(I) complexes Au(III) complexes anticancer activity phosphines N-heterocyclic carbenes |
topic |
Au(I) complexes Au(III) complexes anticancer activity phosphines N-heterocyclic carbenes |
description |
Gold compounds engage an important place in the field of medicinal chemistry due to their therapeutic properties. Since the last four decades, Au(I) and Au(III) complexes have attracted the attention of researchers due to their anti-tumor proprieties and the different mechanisms of action they display in comparison to conventional anticancer platinum compounds. Au(I/III) complexes can inhibit the activity of enzymes containing thiols including thioredoxin reductase; nevertheless, the affinity for several therapeutic targets has been confirmed in recent years. The properties conferred by auxiliary ligands such as phosphines (PR3) and N-heterocyclic carbenes (NHCs) to gold complexes have been key to the development of more promising anticancer compounds. In the same way, it has happened with the inclusion of some multidentate ligands in Au(III) complexes, increasing their stability and selectivity for tumor cells. In this review, we discuss the anticancer effects of Au(I) complexes containing PR3 and NHCs ligands as well as Au(III) complexes containing multidentate ligands especially those that have high cytotoxicity and information on the mechanism of action, as well as attempts to target identification and validation. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000801104 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000801104 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.21577/0100-4042.20170566 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.43 n.8 2020 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318120616067072 |