Rhino-orbital-cerebral mucormycosis in a pediatric cancer patient

Detalhes bibliográficos
Autor(a) principal: Couto, Maria Eduarda
Data de Publicação: 2021
Outros Autores: Oliva, Tereza, Alberto, Pedro, Lebre, Ana, Pinto, Armando, Maia Ferreira, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://revistas.rcaap.pt/nascercrescer/article/view/19758
Resumo: Aim: Mucormycosis infections are highly lethal in immunosuppressed patients. The authors present a rare case of successful treatment of the condition. Case description: A 14-year-old male with acute lymphoblastic lymphoma in remission was diagnosed with pansinusitis, cerebral osteomyelitis, and encephalitis with an abscess caused by Rhizopus sp. Neurosurgical drainage, endoscopic sinus surgery, and left eye enucleation were performed, and the patient was simultaneously treated with lipossomal-amphotericin B and posaconazol (later replaced by isavuconazol). However, complications (left frontal lobe herniation and cerebrospinal fluid fistula) ensued, requiring surgical reoperation. Chemotherapy was restarted four months later. Comments: This is a rare case report, in which early and aggressive surgery, antifungal treatment, and multidisciplinary team work were crucial for the successful outcome.
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spelling Rhino-orbital-cerebral mucormycosis in a pediatric cancer patientMucormicose rino-orbito-cerebral num doente oncológico pediátricoCase ReportsAim: Mucormycosis infections are highly lethal in immunosuppressed patients. The authors present a rare case of successful treatment of the condition. Case description: A 14-year-old male with acute lymphoblastic lymphoma in remission was diagnosed with pansinusitis, cerebral osteomyelitis, and encephalitis with an abscess caused by Rhizopus sp. Neurosurgical drainage, endoscopic sinus surgery, and left eye enucleation were performed, and the patient was simultaneously treated with lipossomal-amphotericin B and posaconazol (later replaced by isavuconazol). However, complications (left frontal lobe herniation and cerebrospinal fluid fistula) ensued, requiring surgical reoperation. Chemotherapy was restarted four months later. Comments: This is a rare case report, in which early and aggressive surgery, antifungal treatment, and multidisciplinary team work were crucial for the successful outcome.Objetivo: As infeções por mucormicose associam-se a elevada mortalidade em doentes imunocomprometidos. Os autores descrevem um raro caso clínico de tratamento com sucesso da condição. Descrição do caso: Um rapaz de 14 anos de idade com linfoma linfoblástico agudo em remissão foi diagnosticado com pansinusite, osteomielite cerebral e encefalite com abcesso causada por Rhizopus sp. Foi realizada drenagem neurocirúrgica, cirurgia endoscópica naso-sinusal e enucleação do olho esquerdo. O doente iniciou tratamento com anfotericina B lipossómica e posaconazol (posteriormente substituído por isavuconazol). No entanto, o desenvolvimento de complicações (herniação do lobo frontal esquerdo e fístula de líquido cefalorraquídeano) exigiu reintervenção cirúrgica. Quatro meses depois, foi reiniciada quimioterapia. Comentários: Este é um caso clínico raro, no qual cirurgia precoce e agressiva, antifúngicos adequados e abordagem por uma equipa multidisciplinar foram determinantes para o sucesso alcançado.Centro Hospitalar Universitário do Porto2021-12-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://revistas.rcaap.pt/nascercrescer/article/view/19758eng2183-9417Couto, Maria EduardaOliva, TerezaAlberto, PedroLebre, AnaPinto, ArmandoMaia Ferreira, Anainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T14:55:39Zoai:ojs.revistas.rcaap.pt:article/19758Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:56:31.739348Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Rhino-orbital-cerebral mucormycosis in a pediatric cancer patient
Mucormicose rino-orbito-cerebral num doente oncológico pediátrico
title Rhino-orbital-cerebral mucormycosis in a pediatric cancer patient
spellingShingle Rhino-orbital-cerebral mucormycosis in a pediatric cancer patient
Couto, Maria Eduarda
Case Reports
title_short Rhino-orbital-cerebral mucormycosis in a pediatric cancer patient
title_full Rhino-orbital-cerebral mucormycosis in a pediatric cancer patient
title_fullStr Rhino-orbital-cerebral mucormycosis in a pediatric cancer patient
title_full_unstemmed Rhino-orbital-cerebral mucormycosis in a pediatric cancer patient
title_sort Rhino-orbital-cerebral mucormycosis in a pediatric cancer patient
author Couto, Maria Eduarda
author_facet Couto, Maria Eduarda
Oliva, Tereza
Alberto, Pedro
Lebre, Ana
Pinto, Armando
Maia Ferreira, Ana
author_role author
author2 Oliva, Tereza
Alberto, Pedro
Lebre, Ana
Pinto, Armando
Maia Ferreira, Ana
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Couto, Maria Eduarda
Oliva, Tereza
Alberto, Pedro
Lebre, Ana
Pinto, Armando
Maia Ferreira, Ana
dc.subject.por.fl_str_mv Case Reports
topic Case Reports
description Aim: Mucormycosis infections are highly lethal in immunosuppressed patients. The authors present a rare case of successful treatment of the condition. Case description: A 14-year-old male with acute lymphoblastic lymphoma in remission was diagnosed with pansinusitis, cerebral osteomyelitis, and encephalitis with an abscess caused by Rhizopus sp. Neurosurgical drainage, endoscopic sinus surgery, and left eye enucleation were performed, and the patient was simultaneously treated with lipossomal-amphotericin B and posaconazol (later replaced by isavuconazol). However, complications (left frontal lobe herniation and cerebrospinal fluid fistula) ensued, requiring surgical reoperation. Chemotherapy was restarted four months later. Comments: This is a rare case report, in which early and aggressive surgery, antifungal treatment, and multidisciplinary team work were crucial for the successful outcome.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-27T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistas.rcaap.pt/nascercrescer/article/view/19758
url https://revistas.rcaap.pt/nascercrescer/article/view/19758
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2183-9417
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Centro Hospitalar Universitário do Porto
publisher.none.fl_str_mv Centro Hospitalar Universitário do Porto
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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