Acute Liver Failure Due to Trazodone and Diazepam

Detalhes bibliográficos
Autor(a) principal: Carvalhana, S
Data de Publicação: 2017
Outros Autores: Oliveira, A, Ferreira, P, Resende, M, Perdigoto, R, Barroso, E
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/2788
Resumo: Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians' awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications.
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spelling Acute Liver Failure Due to Trazodone and DiazepamInsuficiência Hepática Aguda Induzida pela Trazodona e DiazepamCHLC CHBPTHCC UCIAntidepressive AgentsDiazepamLiver Failure, Acute/chemically inducedTrazodoneMost antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians' awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications.Sociedade Portuguesa de GastrenterologiaRepositório do Centro Hospitalar Universitário de Lisboa Central, EPECarvalhana, SOliveira, AFerreira, PResende, MPerdigoto, RBarroso, E2017-11-10T16:22:26Z2017-012017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2788engGE Port J Gastroenterol. 2017 Jan;24(1):40-4210.1159/000450878info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:39:38Zoai:repositorio.chlc.min-saude.pt:10400.17/2788Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:07.221250Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Acute Liver Failure Due to Trazodone and Diazepam
Insuficiência Hepática Aguda Induzida pela Trazodona e Diazepam
title Acute Liver Failure Due to Trazodone and Diazepam
spellingShingle Acute Liver Failure Due to Trazodone and Diazepam
Carvalhana, S
CHLC CHBPT
HCC UCI
Antidepressive Agents
Diazepam
Liver Failure, Acute/chemically induced
Trazodone
title_short Acute Liver Failure Due to Trazodone and Diazepam
title_full Acute Liver Failure Due to Trazodone and Diazepam
title_fullStr Acute Liver Failure Due to Trazodone and Diazepam
title_full_unstemmed Acute Liver Failure Due to Trazodone and Diazepam
title_sort Acute Liver Failure Due to Trazodone and Diazepam
author Carvalhana, S
author_facet Carvalhana, S
Oliveira, A
Ferreira, P
Resende, M
Perdigoto, R
Barroso, E
author_role author
author2 Oliveira, A
Ferreira, P
Resende, M
Perdigoto, R
Barroso, E
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Carvalhana, S
Oliveira, A
Ferreira, P
Resende, M
Perdigoto, R
Barroso, E
dc.subject.por.fl_str_mv CHLC CHBPT
HCC UCI
Antidepressive Agents
Diazepam
Liver Failure, Acute/chemically induced
Trazodone
topic CHLC CHBPT
HCC UCI
Antidepressive Agents
Diazepam
Liver Failure, Acute/chemically induced
Trazodone
description Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians' awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-10T16:22:26Z
2017-01
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/2788
url http://hdl.handle.net/10400.17/2788
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv GE Port J Gastroenterol. 2017 Jan;24(1):40-42
10.1159/000450878
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Gastrenterologia
publisher.none.fl_str_mv Sociedade Portuguesa de Gastrenterologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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