Acute Liver Failure due to Trazodone and Diazepam

Detalhes bibliográficos
Autor(a) principal: Carvalhana,Sofia
Data de Publicação: 2017
Outros Autores: Oliveira,Ana, Ferreira,Pedro, Resende,Margarida, Perdigoto,Rui, Barroso,Eduardo
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007
Resumo: Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians’ awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications.
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spelling Acute Liver Failure due to Trazodone and DiazepamAntidepressive agentsDiazepamLiver failure, acute/chemically inducedTrazodoneMost antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians’ awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications.Sociedade Portuguesa de Gastrenterologia2017-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007GE-Portuguese Journal of Gastroenterology v.24 n.1 2017reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007Carvalhana,SofiaOliveira,AnaFerreira,PedroResende,MargaridaPerdigoto,RuiBarroso,Eduardoinfo:eu-repo/semantics/openAccess2024-02-06T17:33:44Zoai:scielo:S2341-45452017000100007Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:35:59.552873Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Acute Liver Failure due to Trazodone and Diazepam
title Acute Liver Failure due to Trazodone and Diazepam
spellingShingle Acute Liver Failure due to Trazodone and Diazepam
Carvalhana,Sofia
Antidepressive agents
Diazepam
Liver failure, acute/chemically induced
Trazodone
title_short Acute Liver Failure due to Trazodone and Diazepam
title_full Acute Liver Failure due to Trazodone and Diazepam
title_fullStr Acute Liver Failure due to Trazodone and Diazepam
title_full_unstemmed Acute Liver Failure due to Trazodone and Diazepam
title_sort Acute Liver Failure due to Trazodone and Diazepam
author Carvalhana,Sofia
author_facet Carvalhana,Sofia
Oliveira,Ana
Ferreira,Pedro
Resende,Margarida
Perdigoto,Rui
Barroso,Eduardo
author_role author
author2 Oliveira,Ana
Ferreira,Pedro
Resende,Margarida
Perdigoto,Rui
Barroso,Eduardo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalhana,Sofia
Oliveira,Ana
Ferreira,Pedro
Resende,Margarida
Perdigoto,Rui
Barroso,Eduardo
dc.subject.por.fl_str_mv Antidepressive agents
Diazepam
Liver failure, acute/chemically induced
Trazodone
topic Antidepressive agents
Diazepam
Liver failure, acute/chemically induced
Trazodone
description Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians’ awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications.
publishDate 2017
dc.date.none.fl_str_mv 2017-02-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Gastrenterologia
publisher.none.fl_str_mv Sociedade Portuguesa de Gastrenterologia
dc.source.none.fl_str_mv GE-Portuguese Journal of Gastroenterology v.24 n.1 2017
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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