The First Documented Case of Hb South Florida Variant in Portugal
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16052 |
Resumo: | We present a 39-year-old male, previous smoker, with no other known cardiovascular risk factors. He was referred to Internal Medicine for study of thrombophilia, because of repeated deep vein thrombosis. Multiple diagnostic tests were undertaken where HbA1c assay was included. The result was 14.6%. The patient did not have a prior diagnosis of diabetes and denied any symptoms. Fasting blood glucose and blood count did not reveal any changes. A further analysis of hemoglobin subtypes showed the presence of an unclassified variant. The sample was sent to a Portuguese reference center and, through molecular biology, an HBB mutation in heterozygosity was identified, coding for an hemoglobin variant - Hb South Florida (c.4G > A; p.Val2Met), which was for the first time documented in Portugal. We emphasize the importance of considering the presence of hemoglobin variants when HbA1C values are discrepant from the clinical presentation. |
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The First Documented Case of Hb South Florida Variant in PortugalO Primeiro Caso da Variante Hb South Florida em PortugalDiabetes MellitusGlycated Hemoglobin AHemoglobinsAbnormalDiabetes MellitusHemoglobina A GlicadaHemoglobinas AnormaisWe present a 39-year-old male, previous smoker, with no other known cardiovascular risk factors. He was referred to Internal Medicine for study of thrombophilia, because of repeated deep vein thrombosis. Multiple diagnostic tests were undertaken where HbA1c assay was included. The result was 14.6%. The patient did not have a prior diagnosis of diabetes and denied any symptoms. Fasting blood glucose and blood count did not reveal any changes. A further analysis of hemoglobin subtypes showed the presence of an unclassified variant. The sample was sent to a Portuguese reference center and, through molecular biology, an HBB mutation in heterozygosity was identified, coding for an hemoglobin variant - Hb South Florida (c.4G > A; p.Val2Met), which was for the first time documented in Portugal. We emphasize the importance of considering the presence of hemoglobin variants when HbA1C values are discrepant from the clinical presentation.Apresenta-se o caso de um homem de 39 anos, ex-fumador, sem outros fatores de risco conhecidos. Foi encaminhado à consulta de Medicina Interna para estudo de trombofilia por tromboses venosas profundas de repetição. Foi realizado estudo etiológico, onde o doseamento da HbA1c foi incluído. O resultado foi de 14,6%. O doente não apresentava diagnóstico prévio de diabetes mellitus e negava sintomas compatíveis. A glicemia em jejum e o hemograma não revelaram alterações. O estudo por eletroforese das hemoglobinas revelou uma variante não classificada. Num centro de referência português foi identificada, por biologia molecular, uma mutação em heterozigotia no gene HBB associada a uma variante de hemoglobina - Hb South Florida (c.4G > A; p.Val2Met), sendo a primeira vez que é documentada em Portugal. Salienta-se a importância de, na presença de valores de HbA1C discrepantes da apresentação clínica, considerar a presença de variantes de hemoglobina.Ordem dos Médicos2022-04-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16052oai:ojs.www.actamedicaportuguesa.com:article/16052Acta Médica Portuguesa; Vol. 35 No. 10 (2022): October; 770-772Acta Médica Portuguesa; Vol. 35 N.º 10 (2022): Outubro; 770-7721646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16052https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16052/6619Direitos de Autor (c) 2022 Acta Médica Portuguesahttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessBraga Martins, MartaDias, LuísGomes, VâniaRodrigues, Céu2022-12-20T11:07:44Zoai:ojs.www.actamedicaportuguesa.com:article/16052Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:20:44.783849Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The First Documented Case of Hb South Florida Variant in Portugal O Primeiro Caso da Variante Hb South Florida em Portugal |
title |
The First Documented Case of Hb South Florida Variant in Portugal |
spellingShingle |
The First Documented Case of Hb South Florida Variant in Portugal Braga Martins, Marta Diabetes Mellitus Glycated Hemoglobin A Hemoglobins Abnormal Diabetes Mellitus Hemoglobina A Glicada Hemoglobinas Anormais |
title_short |
The First Documented Case of Hb South Florida Variant in Portugal |
title_full |
The First Documented Case of Hb South Florida Variant in Portugal |
title_fullStr |
The First Documented Case of Hb South Florida Variant in Portugal |
title_full_unstemmed |
The First Documented Case of Hb South Florida Variant in Portugal |
title_sort |
The First Documented Case of Hb South Florida Variant in Portugal |
author |
Braga Martins, Marta |
author_facet |
Braga Martins, Marta Dias, Luís Gomes, Vânia Rodrigues, Céu |
author_role |
author |
author2 |
Dias, Luís Gomes, Vânia Rodrigues, Céu |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Braga Martins, Marta Dias, Luís Gomes, Vânia Rodrigues, Céu |
dc.subject.por.fl_str_mv |
Diabetes Mellitus Glycated Hemoglobin A Hemoglobins Abnormal Diabetes Mellitus Hemoglobina A Glicada Hemoglobinas Anormais |
topic |
Diabetes Mellitus Glycated Hemoglobin A Hemoglobins Abnormal Diabetes Mellitus Hemoglobina A Glicada Hemoglobinas Anormais |
description |
We present a 39-year-old male, previous smoker, with no other known cardiovascular risk factors. He was referred to Internal Medicine for study of thrombophilia, because of repeated deep vein thrombosis. Multiple diagnostic tests were undertaken where HbA1c assay was included. The result was 14.6%. The patient did not have a prior diagnosis of diabetes and denied any symptoms. Fasting blood glucose and blood count did not reveal any changes. A further analysis of hemoglobin subtypes showed the presence of an unclassified variant. The sample was sent to a Portuguese reference center and, through molecular biology, an HBB mutation in heterozygosity was identified, coding for an hemoglobin variant - Hb South Florida (c.4G > A; p.Val2Met), which was for the first time documented in Portugal. We emphasize the importance of considering the presence of hemoglobin variants when HbA1C values are discrepant from the clinical presentation. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-13 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16052 oai:ojs.www.actamedicaportuguesa.com:article/16052 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16052 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/16052 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16052 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16052/6619 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2022 Acta Médica Portuguesa http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos de Autor (c) 2022 Acta Médica Portuguesa http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 35 No. 10 (2022): October; 770-772 Acta Médica Portuguesa; Vol. 35 N.º 10 (2022): Outubro; 770-772 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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