An alternative in the diagnosis and monitoring of Diabetes Mellitus to detection via biomarkers: a systematic review

Detalhes bibliográficos
Autor(a) principal: Silva, Maria Clara Gomes
Data de Publicação: 2021
Outros Autores: Rêgo, Jardes Figuerêdo do
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/18736
Resumo: Diabetes Mellitus is a highly prevalent metabolic disorder of the beta-pancreatic cells worldwide. The diagnosis currently occurs by using glycemic tests combined with the dosage of some biomarkers. Therefore, this paper aims to analyze clinical techniques for diagnosis and therapeutic monitoring of diabetes mellitus, highlighting alternative and compensatory forms. A systematic review was carried out via survey in SCIELO, PUBMED and LILACS platforms. The keywords used were combined in English and Portuguese. The time frame established includes the years 2010 to 2021. Finally, data were organized via Prisma statement flowchart, summary table, and GRADE evidence scale. In their research, the authors reported that the glycated hemoglobin should not be used in screening for pre-diabetes, besides having interferences. As for the glycated albumin, it will act as a substitute and helps in detecting complications arising from diabetes, in the same way as the 1.5 anhydroglucitol, in addition, it can detect the chances of mortality from the disease. And finally, anti-GAD and C-peptide help in the detection of type 1 diabetes, evaluation of insulin therapy, and research into the development of autoimmune diseases. Although biomarkers have great benefits, the use of glycemic tests is still preferable. Finally, through this study it is possible to verify that biomarkers are alternative methodologies that can still be improved, are effective in detecting the disease, but are not yet used unattended or applied effectively in gestational diabetes. Moreover, they not only alert to the risks of developing complications but are also surgical parameteres.
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spelling An alternative in the diagnosis and monitoring of Diabetes Mellitus to detection via biomarkers: a systematic review Una alternativa em el diagnóstico y seguimiento de la Diabetes Mellitus a la detección mediante biomarcadores: una revisión sistemáticaUma alternativa no diagnóstico e monitoramento de Diabetes Mellitus a detecção via biomarcadores: uma revisão sistemática 1,5-AnhydroglucitolDiabetes MellitusGlycated Hemoglobin AC Peptide.1,5-AnhidroglucitolDiabetes MellitusHemoglobina A GlucadaPéptido C.1.5-AnidroglucitolDiabetes MellitusHemoglobina A GlicadaPeptídeo C.Diabetes Mellitus is a highly prevalent metabolic disorder of the beta-pancreatic cells worldwide. The diagnosis currently occurs by using glycemic tests combined with the dosage of some biomarkers. Therefore, this paper aims to analyze clinical techniques for diagnosis and therapeutic monitoring of diabetes mellitus, highlighting alternative and compensatory forms. A systematic review was carried out via survey in SCIELO, PUBMED and LILACS platforms. The keywords used were combined in English and Portuguese. The time frame established includes the years 2010 to 2021. Finally, data were organized via Prisma statement flowchart, summary table, and GRADE evidence scale. In their research, the authors reported that the glycated hemoglobin should not be used in screening for pre-diabetes, besides having interferences. As for the glycated albumin, it will act as a substitute and helps in detecting complications arising from diabetes, in the same way as the 1.5 anhydroglucitol, in addition, it can detect the chances of mortality from the disease. And finally, anti-GAD and C-peptide help in the detection of type 1 diabetes, evaluation of insulin therapy, and research into the development of autoimmune diseases. Although biomarkers have great benefits, the use of glycemic tests is still preferable. Finally, through this study it is possible to verify that biomarkers are alternative methodologies that can still be improved, are effective in detecting the disease, but are not yet used unattended or applied effectively in gestational diabetes. Moreover, they not only alert to the risks of developing complications but are also surgical parameteres.La Diabetes Mellitus es un trastorno metabólico de alta prevalencia en las células beta del páncreas en todo el mundo. En la actualidad, el diagnóstico se realiza mediante el uso de pruebas glucémicas combinadas con la dosificación de algunos biomarcadores. Además, el trabajo tiene como objetivo analizar las técnicas clínicas para el diagnóstico y el seguimiento terapéutico de la diabetes mellitus, destacando las formas alternativas y compensatorias. Se realizó una revisión sistemática mediante encuesta en las plataformas SCIELO, PUBMED y LILACS. Las palabras clave utilizadas se combinaron en inglés y portugués. El marco temporal establecido incluye los años 2010 a 2021. Por último, los datos se organizaron mediante el diagrama de flujo de declaraciones Prisma, la tabla de resumen y la escala de evidencia GRADE. Em la investigación, los autores relatan que la hemoglobina glicada no debe utilizarse en el rastreo de la prediabetes, además de poseer interferencias. En cuanto a la albúmina glicosilada, actuará como sustituto y ayuda a detectar las complicaciones de la diabetes, del mismo modo que el 1,5 anhidroglucitol, además, puede detectar las posibilidades de mortalidad por la enfermedad. Y, por último, los anti-GAD y el péptido C ayudan a detectar la diabetes de tipo 1, a evaluar el tratamiento con insulina y a investigar el desarrollo de enfermedades autoinmunes. Aunque los biomarcadores presentan grandes ventajas, sigue siendo preferible el uso de pruebas de glucemia. Finalmente, a través del estudio realizado, es posible comprobar que los biomarcadores son metodologías alternativas que aún pueden ser mejoradas, son eficaces en la detección de la enfermedad, pero aún no son utilizados de forma desatendida o aplicada de forma efectiva en la diabetes gestacional. Además, no solo alertan de los riesgos de desarrollar complicaciones, sino que también son parâmetros quirúrgicos.A Diabetes Mellitus é um distúrbio metabólico, de alta prevalência mundial, das células beta-pancreáticas. O diagnóstico atualmente ocorre por uso de testes glicêmicos combinados com a dosagem de alguns biomarcadores. Portanto, o trabalho objetiva analisar técnicas clínicas para diagnóstico e monitoramento terapêutico da diabetes mellitus, destacando formas alternativas e compensatórias. Foi realizada uma revisão sistemática via levantamento nas plataformas SCIELO, PUBMED e LILACS. As palavras-chave utilizadas foram combinadas nas línguas inglesa e portuguesa. O recorte temporal estabelecido inclui os anos de 2010 a 2021. Por fim, os dados foram organizados via fluxograma Prisma statement, quadro-resumo e escala de evidência GRADE. Na pesquisa, os autores relataram que a hemoglobina glicada não deve ser utilizada no rastreio de pré-diabetes, além de possuir interferentes. Quanto à albumina glicada, esta vai atuar como substituto e auxilia na detecção de complicações advindas da diabetes, da mesma maneira que o 1,5 anidroglucitol, além disso, pode detectar as chances de mortalidade pela doença. E por fim, o anti-GAD e o peptídeo C auxiliam na detecção da diabetes tipo 1, avaliação da insulinoterapia e pesquisa de desenvolvimento de doenças autoimunes. Apesar dos biomarcadores apresentarem grandes benefícios, ainda é preferível o uso de testes glicêmicos. Enfim, por meio do estudo realizado é possível averiguar que os biomarcadores são metodologias alternativas que ainda podem ser aperfeiçoadas, são eficazes na detecção da doença, mas ainda não são utilizados desacompanhados ou aplicados efetivamente na diabetes gestacional. Além disso, não só alertam para os riscos de desenvolver complicações como são parâmetros cirúrgicos.Research, Society and Development2021-08-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1873610.33448/rsd-v10i10.18736Research, Society and Development; Vol. 10 No. 10; e135101018736Research, Society and Development; Vol. 10 Núm. 10; e135101018736Research, Society and Development; v. 10 n. 10; e1351010187362525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/18736/16672Copyright (c) 2021 Maria Clara Gomes Silva; Jardes Figuerêdo do Rêgohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Maria Clara GomesRêgo, Jardes Figuerêdo do2021-10-02T21:49:16Zoai:ojs.pkp.sfu.ca:article/18736Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:48.016944Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv An alternative in the diagnosis and monitoring of Diabetes Mellitus to detection via biomarkers: a systematic review
Una alternativa em el diagnóstico y seguimiento de la Diabetes Mellitus a la detección mediante biomarcadores: una revisión sistemática
Uma alternativa no diagnóstico e monitoramento de Diabetes Mellitus a detecção via biomarcadores: uma revisão sistemática
title An alternative in the diagnosis and monitoring of Diabetes Mellitus to detection via biomarkers: a systematic review
spellingShingle An alternative in the diagnosis and monitoring of Diabetes Mellitus to detection via biomarkers: a systematic review
Silva, Maria Clara Gomes
1,5-Anhydroglucitol
Diabetes Mellitus
Glycated Hemoglobin A
C Peptide.
1,5-Anhidroglucitol
Diabetes Mellitus
Hemoglobina A Glucada
Péptido C.
1.5-Anidroglucitol
Diabetes Mellitus
Hemoglobina A Glicada
Peptídeo C.
title_short An alternative in the diagnosis and monitoring of Diabetes Mellitus to detection via biomarkers: a systematic review
title_full An alternative in the diagnosis and monitoring of Diabetes Mellitus to detection via biomarkers: a systematic review
title_fullStr An alternative in the diagnosis and monitoring of Diabetes Mellitus to detection via biomarkers: a systematic review
title_full_unstemmed An alternative in the diagnosis and monitoring of Diabetes Mellitus to detection via biomarkers: a systematic review
title_sort An alternative in the diagnosis and monitoring of Diabetes Mellitus to detection via biomarkers: a systematic review
author Silva, Maria Clara Gomes
author_facet Silva, Maria Clara Gomes
Rêgo, Jardes Figuerêdo do
author_role author
author2 Rêgo, Jardes Figuerêdo do
author2_role author
dc.contributor.author.fl_str_mv Silva, Maria Clara Gomes
Rêgo, Jardes Figuerêdo do
dc.subject.por.fl_str_mv 1,5-Anhydroglucitol
Diabetes Mellitus
Glycated Hemoglobin A
C Peptide.
1,5-Anhidroglucitol
Diabetes Mellitus
Hemoglobina A Glucada
Péptido C.
1.5-Anidroglucitol
Diabetes Mellitus
Hemoglobina A Glicada
Peptídeo C.
topic 1,5-Anhydroglucitol
Diabetes Mellitus
Glycated Hemoglobin A
C Peptide.
1,5-Anhidroglucitol
Diabetes Mellitus
Hemoglobina A Glucada
Péptido C.
1.5-Anidroglucitol
Diabetes Mellitus
Hemoglobina A Glicada
Peptídeo C.
description Diabetes Mellitus is a highly prevalent metabolic disorder of the beta-pancreatic cells worldwide. The diagnosis currently occurs by using glycemic tests combined with the dosage of some biomarkers. Therefore, this paper aims to analyze clinical techniques for diagnosis and therapeutic monitoring of diabetes mellitus, highlighting alternative and compensatory forms. A systematic review was carried out via survey in SCIELO, PUBMED and LILACS platforms. The keywords used were combined in English and Portuguese. The time frame established includes the years 2010 to 2021. Finally, data were organized via Prisma statement flowchart, summary table, and GRADE evidence scale. In their research, the authors reported that the glycated hemoglobin should not be used in screening for pre-diabetes, besides having interferences. As for the glycated albumin, it will act as a substitute and helps in detecting complications arising from diabetes, in the same way as the 1.5 anhydroglucitol, in addition, it can detect the chances of mortality from the disease. And finally, anti-GAD and C-peptide help in the detection of type 1 diabetes, evaluation of insulin therapy, and research into the development of autoimmune diseases. Although biomarkers have great benefits, the use of glycemic tests is still preferable. Finally, through this study it is possible to verify that biomarkers are alternative methodologies that can still be improved, are effective in detecting the disease, but are not yet used unattended or applied effectively in gestational diabetes. Moreover, they not only alert to the risks of developing complications but are also surgical parameteres.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/18736
10.33448/rsd-v10i10.18736
url https://rsdjournal.org/index.php/rsd/article/view/18736
identifier_str_mv 10.33448/rsd-v10i10.18736
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/18736/16672
dc.rights.driver.fl_str_mv Copyright (c) 2021 Maria Clara Gomes Silva; Jardes Figuerêdo do Rêgo
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Maria Clara Gomes Silva; Jardes Figuerêdo do Rêgo
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 10; e135101018736
Research, Society and Development; Vol. 10 Núm. 10; e135101018736
Research, Society and Development; v. 10 n. 10; e135101018736
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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