Chemical modification strategies to prepare advanced protein-based biomaterials
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/36917 |
Resumo: | Nature is a superb source of inspiration when it comes to the development of biomaterials. Proteins, an exquisite asset virtually involved in all biological functions, are envisioned as a biomaterial due to their ability to be chemically modified. Owing to the rich chemical repertoire provided by the side chains and C-/N-terminus present in their backbone, scientists are pursuing chemical ways to upgrade isolated proteins, while maintaining their biological activity or relevant structural properties. By inserting chemical motifs, the crosslinking capability of proteins and capability to attach biochemical and molecular groups can be controlled yielding nano to macro constructs and hydrogels with improved physicochemical and mechanical properties. These cutting-edge approaches elevate the potential use of proteins as promising biomaterials for biotechnology and biomedicine. |
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Chemical modification strategies to prepare advanced protein-based biomaterialsNature is a superb source of inspiration when it comes to the development of biomaterials. Proteins, an exquisite asset virtually involved in all biological functions, are envisioned as a biomaterial due to their ability to be chemically modified. Owing to the rich chemical repertoire provided by the side chains and C-/N-terminus present in their backbone, scientists are pursuing chemical ways to upgrade isolated proteins, while maintaining their biological activity or relevant structural properties. By inserting chemical motifs, the crosslinking capability of proteins and capability to attach biochemical and molecular groups can be controlled yielding nano to macro constructs and hydrogels with improved physicochemical and mechanical properties. These cutting-edge approaches elevate the potential use of proteins as promising biomaterials for biotechnology and biomedicine.Elsevier2023-04-06T15:17:18Z2021-03-01T00:00:00Z2021-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/36917eng2666-534410.1016/j.bbiosy.2021.100010Gomes, Maria C.Mano, João F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:11:12Zoai:ria.ua.pt:10773/36917Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:07:35.044839Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Chemical modification strategies to prepare advanced protein-based biomaterials |
title |
Chemical modification strategies to prepare advanced protein-based biomaterials |
spellingShingle |
Chemical modification strategies to prepare advanced protein-based biomaterials Gomes, Maria C. |
title_short |
Chemical modification strategies to prepare advanced protein-based biomaterials |
title_full |
Chemical modification strategies to prepare advanced protein-based biomaterials |
title_fullStr |
Chemical modification strategies to prepare advanced protein-based biomaterials |
title_full_unstemmed |
Chemical modification strategies to prepare advanced protein-based biomaterials |
title_sort |
Chemical modification strategies to prepare advanced protein-based biomaterials |
author |
Gomes, Maria C. |
author_facet |
Gomes, Maria C. Mano, João F. |
author_role |
author |
author2 |
Mano, João F. |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Gomes, Maria C. Mano, João F. |
description |
Nature is a superb source of inspiration when it comes to the development of biomaterials. Proteins, an exquisite asset virtually involved in all biological functions, are envisioned as a biomaterial due to their ability to be chemically modified. Owing to the rich chemical repertoire provided by the side chains and C-/N-terminus present in their backbone, scientists are pursuing chemical ways to upgrade isolated proteins, while maintaining their biological activity or relevant structural properties. By inserting chemical motifs, the crosslinking capability of proteins and capability to attach biochemical and molecular groups can be controlled yielding nano to macro constructs and hydrogels with improved physicochemical and mechanical properties. These cutting-edge approaches elevate the potential use of proteins as promising biomaterials for biotechnology and biomedicine. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-01T00:00:00Z 2021-03 2023-04-06T15:17:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/36917 |
url |
http://hdl.handle.net/10773/36917 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2666-5344 10.1016/j.bbiosy.2021.100010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137730487123968 |