Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in French Guiana
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/163959 |
Resumo: | Copyright © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved. |
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Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in French Guianaa descriptive epidemiological studymalariaQR MicrobiologyRM Therapeutics. PharmacologyInfectious DiseasesMicrobiology (medical)ParasitologyGeneral Pharmacology, Toxicology and PharmaceuticsEpidemiologySDG 3 - Good Health and Well-beingSDG 10 - Reduced InequalitiesCopyright © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.BACKGROUND: Plasmodium falciparum is an apicomplexan parasite responsible for lethal cases of malaria. According to WHO recommendations, P falciparum cases are treated with artemisinin-based combination therapy including dihydroartemisinin-piperaquine. However, the emergence of resistant parasites against dihydroartemisinin-piperaquine was reported in southeast Asia in 2008 and, a few years later, suspected in South America. METHODS: To characterise resistance emergence, a treatment efficacy study was performed on the reported patients infected with P falciparum and treated with dihydroartemisinin-piperaquine in French Guiana (n=6, 2016-18). Contemporary isolates collected in French Guiana were genotyped for P falciparum chloroquine resistance transporter (pfCRT; n=845) and pfpm2 and pfpm3 copy number (n=231), phenotyped using the in vitro piperaquine survival assay (n=86), and analysed through genomic studies (n=50). Additional samples from five Amazonian countries and one outside the region were genotyped (n=1440). FINDINGS: In field isolates, 40 (47%) of 86 (95% CI 35·9-57·1) were resistant to piperaquine in vitro; these phenotypes were more associated with pfCRT C350R (ie, Cys350Arg) and pfpm2 and pfpm3 amplifications (Dunn test, p<0·001). Those markers were also associated with dihydroartemisinin-piperaquine treatment failure (n=3 [50%] of 6). A high prevalence of piperaquine resistance markers was observed in Suriname in 19 (83%) of 35 isolates and in Guyana in 579 (73%) of 791 isolates. The pfCRT C350R mutation emerged before pfpm2 and pfpm3 amplification in a temporal sequence different from southeast Asia, and in the absence of artemisinin partial resistance, suggesting a geographically distinctive epistatic relationship between these genetic markers. INTERPRETATION: The high prevalence of piperaquine resistance markers in parasite populations of the Guianas, and the risk of associated therapeutic failures calls for caution on dihydroartemisinin-piperaquine use in the region. Furthermore, greater attention should be given to potential differences in genotype to phenotype mapping across genetically distinct parasite populations from different continents. FUNDING: Pan American Health Organization and WHO, French Ministry for Research, European Commission, Santé publique France, Agence Nationale de la Recherche, Fundação de Amparo à Pesquisa do Estado do Amazonas, Ministry of Health of Brazil, Oswaldo Cruz Foundation, and National Institutes of Health. TRANSLATIONS: For the French and Portuguese translations of the abstract see Supplementary Materials section.Individual Health Care (IHC)Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)RUNFlorimond, Celiade Laval, FranckEarly, Angela MSauthier, SwaélieLazrek, YassaminePelleau, StéphaneMonteiro, Wuelton MAgranier, MaximeTaudon, NicolasMorin, FrançoisMagris, MagdaLacerda, Marcus V GViana, Giselle M RHerrera, SócratesAdhin, Malti RFerreira, Marcelo UWoodrow, Charles JAwab, Ghulam RCox, HoraceAde, Maria-PazMosnier, EmilieDjossou, FélixNeafsey, Daniel ERingwald, PascalMusset, Lise2024-02-22T23:25:00Z2023-10-162023-10-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/163959eng1473-3099PURE: 77161626https://doi.org/10.1016/S1473-3099(23)00502-9info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:18:43Zoai:run.unl.pt:10362/163959Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:18:43Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in French Guiana a descriptive epidemiological study |
| title |
Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in French Guiana |
| spellingShingle |
Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in French Guiana Florimond, Celia malaria QR Microbiology RM Therapeutics. Pharmacology Infectious Diseases Microbiology (medical) Parasitology General Pharmacology, Toxicology and Pharmaceutics Epidemiology SDG 3 - Good Health and Well-being SDG 10 - Reduced Inequalities |
| title_short |
Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in French Guiana |
| title_full |
Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in French Guiana |
| title_fullStr |
Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in French Guiana |
| title_full_unstemmed |
Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in French Guiana |
| title_sort |
Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in French Guiana |
| author |
Florimond, Celia |
| author_facet |
Florimond, Celia de Laval, Franck Early, Angela M Sauthier, Swaélie Lazrek, Yassamine Pelleau, Stéphane Monteiro, Wuelton M Agranier, Maxime Taudon, Nicolas Morin, François Magris, Magda Lacerda, Marcus V G Viana, Giselle M R Herrera, Sócrates Adhin, Malti R Ferreira, Marcelo U Woodrow, Charles J Awab, Ghulam R Cox, Horace Ade, Maria-Paz Mosnier, Emilie Djossou, Félix Neafsey, Daniel E Ringwald, Pascal Musset, Lise |
| author_role |
author |
| author2 |
de Laval, Franck Early, Angela M Sauthier, Swaélie Lazrek, Yassamine Pelleau, Stéphane Monteiro, Wuelton M Agranier, Maxime Taudon, Nicolas Morin, François Magris, Magda Lacerda, Marcus V G Viana, Giselle M R Herrera, Sócrates Adhin, Malti R Ferreira, Marcelo U Woodrow, Charles J Awab, Ghulam R Cox, Horace Ade, Maria-Paz Mosnier, Emilie Djossou, Félix Neafsey, Daniel E Ringwald, Pascal Musset, Lise |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Individual Health Care (IHC) Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) RUN |
| dc.contributor.author.fl_str_mv |
Florimond, Celia de Laval, Franck Early, Angela M Sauthier, Swaélie Lazrek, Yassamine Pelleau, Stéphane Monteiro, Wuelton M Agranier, Maxime Taudon, Nicolas Morin, François Magris, Magda Lacerda, Marcus V G Viana, Giselle M R Herrera, Sócrates Adhin, Malti R Ferreira, Marcelo U Woodrow, Charles J Awab, Ghulam R Cox, Horace Ade, Maria-Paz Mosnier, Emilie Djossou, Félix Neafsey, Daniel E Ringwald, Pascal Musset, Lise |
| dc.subject.por.fl_str_mv |
malaria QR Microbiology RM Therapeutics. Pharmacology Infectious Diseases Microbiology (medical) Parasitology General Pharmacology, Toxicology and Pharmaceutics Epidemiology SDG 3 - Good Health and Well-being SDG 10 - Reduced Inequalities |
| topic |
malaria QR Microbiology RM Therapeutics. Pharmacology Infectious Diseases Microbiology (medical) Parasitology General Pharmacology, Toxicology and Pharmaceutics Epidemiology SDG 3 - Good Health and Well-being SDG 10 - Reduced Inequalities |
| description |
Copyright © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-10-16 2023-10-16T00:00:00Z 2024-02-22T23:25:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/163959 |
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http://hdl.handle.net/10362/163959 |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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1473-3099 PURE: 77161626 https://doi.org/10.1016/S1473-3099(23)00502-9 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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