Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/5830 https://doi.org/10.1016/j.memsci.2008.04.011 |
Resumo: | Novel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interaction between the polymers was maximized controlling the pH, and by forming the films at a pH value close to the pKa of the respective components as identified by potentiometric and turbidimetric titrations. The action of glycerol, PEG200, Hydrovance and trehalose upon the functional properties of the films was also evaluated. Glycerol was found to improve the film properties in terms of flexibility, resistance and water vapour transmission rate (WVTR) with a maximum effect at 30%. The application of a pressure sensitive adhesive (PSA) significantly improved bioadhesion with a negligible influence in the resistance and flexibility of the films. |
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Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterizationChitosanPolyelectrolyte complexesGlycerolSkin drug deliveryNovel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interaction between the polymers was maximized controlling the pH, and by forming the films at a pH value close to the pKa of the respective components as identified by potentiometric and turbidimetric titrations. The action of glycerol, PEG200, Hydrovance and trehalose upon the functional properties of the films was also evaluated. Glycerol was found to improve the film properties in terms of flexibility, resistance and water vapour transmission rate (WVTR) with a maximum effect at 30%. The application of a pressure sensitive adhesive (PSA) significantly improved bioadhesion with a negligible influence in the resistance and flexibility of the films.http://www.sciencedirect.com/science/article/B6TGK-4S8CR51-5/1/cdb82032d8e533445099d1ce53f2922a2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5830http://hdl.handle.net/10316/5830https://doi.org/10.1016/j.memsci.2008.04.011engJournal of Membrane Science. 320:1-2 (2008) 268-279Silva, Cláudia L.Pereira, Jorge C.Ramalho, AmílcarPais, Alberto A. C. C.Sousa, João J. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-11-06T16:49:15Zoai:estudogeral.uc.pt:10316/5830Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:22.485653Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization |
title |
Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization |
spellingShingle |
Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization Silva, Cláudia L. Chitosan Polyelectrolyte complexes Glycerol Skin drug delivery |
title_short |
Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization |
title_full |
Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization |
title_fullStr |
Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization |
title_full_unstemmed |
Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization |
title_sort |
Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization |
author |
Silva, Cláudia L. |
author_facet |
Silva, Cláudia L. Pereira, Jorge C. Ramalho, Amílcar Pais, Alberto A. C. C. Sousa, João J. S. |
author_role |
author |
author2 |
Pereira, Jorge C. Ramalho, Amílcar Pais, Alberto A. C. C. Sousa, João J. S. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Silva, Cláudia L. Pereira, Jorge C. Ramalho, Amílcar Pais, Alberto A. C. C. Sousa, João J. S. |
dc.subject.por.fl_str_mv |
Chitosan Polyelectrolyte complexes Glycerol Skin drug delivery |
topic |
Chitosan Polyelectrolyte complexes Glycerol Skin drug delivery |
description |
Novel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interaction between the polymers was maximized controlling the pH, and by forming the films at a pH value close to the pKa of the respective components as identified by potentiometric and turbidimetric titrations. The action of glycerol, PEG200, Hydrovance and trehalose upon the functional properties of the films was also evaluated. Glycerol was found to improve the film properties in terms of flexibility, resistance and water vapour transmission rate (WVTR) with a maximum effect at 30%. The application of a pressure sensitive adhesive (PSA) significantly improved bioadhesion with a negligible influence in the resistance and flexibility of the films. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/5830 http://hdl.handle.net/10316/5830 https://doi.org/10.1016/j.memsci.2008.04.011 |
url |
http://hdl.handle.net/10316/5830 https://doi.org/10.1016/j.memsci.2008.04.011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Membrane Science. 320:1-2 (2008) 268-279 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
aplication/PDF |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133751105552384 |