Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization

Detalhes bibliográficos
Autor(a) principal: Silva, Cláudia L.
Data de Publicação: 2008
Outros Autores: Pereira, Jorge C., Ramalho, Amílcar, Pais, Alberto A. C. C., Sousa, João J. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/5830
https://doi.org/10.1016/j.memsci.2008.04.011
Resumo: Novel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interaction between the polymers was maximized controlling the pH, and by forming the films at a pH value close to the pKa of the respective components as identified by potentiometric and turbidimetric titrations. The action of glycerol, PEG200, Hydrovance and trehalose upon the functional properties of the films was also evaluated. Glycerol was found to improve the film properties in terms of flexibility, resistance and water vapour transmission rate (WVTR) with a maximum effect at 30%. The application of a pressure sensitive adhesive (PSA) significantly improved bioadhesion with a negligible influence in the resistance and flexibility of the films.
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spelling Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterizationChitosanPolyelectrolyte complexesGlycerolSkin drug deliveryNovel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interaction between the polymers was maximized controlling the pH, and by forming the films at a pH value close to the pKa of the respective components as identified by potentiometric and turbidimetric titrations. The action of glycerol, PEG200, Hydrovance and trehalose upon the functional properties of the films was also evaluated. Glycerol was found to improve the film properties in terms of flexibility, resistance and water vapour transmission rate (WVTR) with a maximum effect at 30%. The application of a pressure sensitive adhesive (PSA) significantly improved bioadhesion with a negligible influence in the resistance and flexibility of the films.http://www.sciencedirect.com/science/article/B6TGK-4S8CR51-5/1/cdb82032d8e533445099d1ce53f2922a2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5830http://hdl.handle.net/10316/5830https://doi.org/10.1016/j.memsci.2008.04.011engJournal of Membrane Science. 320:1-2 (2008) 268-279Silva, Cláudia L.Pereira, Jorge C.Ramalho, AmílcarPais, Alberto A. C. C.Sousa, João J. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-11-06T16:49:15Zoai:estudogeral.uc.pt:10316/5830Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:22.485653Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization
title Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization
spellingShingle Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization
Silva, Cláudia L.
Chitosan
Polyelectrolyte complexes
Glycerol
Skin drug delivery
title_short Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization
title_full Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization
title_fullStr Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization
title_full_unstemmed Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization
title_sort Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization
author Silva, Cláudia L.
author_facet Silva, Cláudia L.
Pereira, Jorge C.
Ramalho, Amílcar
Pais, Alberto A. C. C.
Sousa, João J. S.
author_role author
author2 Pereira, Jorge C.
Ramalho, Amílcar
Pais, Alberto A. C. C.
Sousa, João J. S.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva, Cláudia L.
Pereira, Jorge C.
Ramalho, Amílcar
Pais, Alberto A. C. C.
Sousa, João J. S.
dc.subject.por.fl_str_mv Chitosan
Polyelectrolyte complexes
Glycerol
Skin drug delivery
topic Chitosan
Polyelectrolyte complexes
Glycerol
Skin drug delivery
description Novel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interaction between the polymers was maximized controlling the pH, and by forming the films at a pH value close to the pKa of the respective components as identified by potentiometric and turbidimetric titrations. The action of glycerol, PEG200, Hydrovance and trehalose upon the functional properties of the films was also evaluated. Glycerol was found to improve the film properties in terms of flexibility, resistance and water vapour transmission rate (WVTR) with a maximum effect at 30%. The application of a pressure sensitive adhesive (PSA) significantly improved bioadhesion with a negligible influence in the resistance and flexibility of the films.
publishDate 2008
dc.date.none.fl_str_mv 2008
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/5830
http://hdl.handle.net/10316/5830
https://doi.org/10.1016/j.memsci.2008.04.011
url http://hdl.handle.net/10316/5830
https://doi.org/10.1016/j.memsci.2008.04.011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Membrane Science. 320:1-2 (2008) 268-279
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