The role of mitochondria-associated membranes in cellular homeostasis and diseases
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Livro |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/95122 https://doi.org/10.1016/bs.ircmb.2019.11.002 |
Resumo: | Mitochondria and endoplasmic reticulum (ER) are fundamental in the control of cell physiology regulating several signal transduction pathways. They continuously communicate exchanging messages in their contact sites called MAMs (mitochondria-associated membranes). MAMs are specific microdomains acting as a platform for the sorting of vital and dangerous signals. In recent years increasing evidence reported that multiple scaffold proteins and regulatory factors localize to this subcellular fraction suggesting MAMs as hotspot signaling domains. In this review we describe the current knowledge about MAMs' dynamics and processes, which provided new correlations between MAMs' dysfunctions and human diseases. In fact, MAMs machinery is strictly connected with several pathologies, like neurodegeneration, diabetes and mainly cancer. These pathological events are characterized by alterations in the normal communication between ER and mitochondria, leading to deep metabolic defects that contribute to the progression of the diseases. |
id |
RCAP_959084bd0168e3e0530268657b801f00 |
---|---|
oai_identifier_str |
oai:estudogeral.uc.pt:10316/95122 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
The role of mitochondria-associated membranes in cellular homeostasis and diseasesAutophagy; Calcium transfer apoptosis; Cancer; Diabetes; Inflammation and antiviral response; Lipid trafficking and metabolism; Mitochondrial dynamics; Neurodegenerative diseases; ROSMitochondria and endoplasmic reticulum (ER) are fundamental in the control of cell physiology regulating several signal transduction pathways. They continuously communicate exchanging messages in their contact sites called MAMs (mitochondria-associated membranes). MAMs are specific microdomains acting as a platform for the sorting of vital and dangerous signals. In recent years increasing evidence reported that multiple scaffold proteins and regulatory factors localize to this subcellular fraction suggesting MAMs as hotspot signaling domains. In this review we describe the current knowledge about MAMs' dynamics and processes, which provided new correlations between MAMs' dysfunctions and human diseases. In fact, MAMs machinery is strictly connected with several pathologies, like neurodegeneration, diabetes and mainly cancer. These pathological events are characterized by alterations in the normal communication between ER and mitochondria, leading to deep metabolic defects that contribute to the progression of the diseases.Elsevier2020-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookhttp://hdl.handle.net/10316/95122http://hdl.handle.net/10316/95122https://doi.org/10.1016/bs.ircmb.2019.11.002por9780128197448https://www.sciencedirect.com/science/article/pii/S1937644819301042?via%3DihubPerrone, MariasoleCaroccia, NatasciaGenovese, IlariaMissiroli, SoniaModesti, LorenzoPedriali, GaiaVezzani, BiancaVitto, Veronica Angela MariaAntenori, MicheleLebiedzinska-Arciszewska, MagdalenaWieckowski, Mariusz R.Giorgi, CarlottaPinton, Paoloinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-07-12T08:43:17Zoai:estudogeral.uc.pt:10316/95122Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:13:41.975753Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The role of mitochondria-associated membranes in cellular homeostasis and diseases |
title |
The role of mitochondria-associated membranes in cellular homeostasis and diseases |
spellingShingle |
The role of mitochondria-associated membranes in cellular homeostasis and diseases Perrone, Mariasole Autophagy; Calcium transfer apoptosis; Cancer; Diabetes; Inflammation and antiviral response; Lipid trafficking and metabolism; Mitochondrial dynamics; Neurodegenerative diseases; ROS |
title_short |
The role of mitochondria-associated membranes in cellular homeostasis and diseases |
title_full |
The role of mitochondria-associated membranes in cellular homeostasis and diseases |
title_fullStr |
The role of mitochondria-associated membranes in cellular homeostasis and diseases |
title_full_unstemmed |
The role of mitochondria-associated membranes in cellular homeostasis and diseases |
title_sort |
The role of mitochondria-associated membranes in cellular homeostasis and diseases |
author |
Perrone, Mariasole |
author_facet |
Perrone, Mariasole Caroccia, Natascia Genovese, Ilaria Missiroli, Sonia Modesti, Lorenzo Pedriali, Gaia Vezzani, Bianca Vitto, Veronica Angela Maria Antenori, Michele Lebiedzinska-Arciszewska, Magdalena Wieckowski, Mariusz R. Giorgi, Carlotta Pinton, Paolo |
author_role |
author |
author2 |
Caroccia, Natascia Genovese, Ilaria Missiroli, Sonia Modesti, Lorenzo Pedriali, Gaia Vezzani, Bianca Vitto, Veronica Angela Maria Antenori, Michele Lebiedzinska-Arciszewska, Magdalena Wieckowski, Mariusz R. Giorgi, Carlotta Pinton, Paolo |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Perrone, Mariasole Caroccia, Natascia Genovese, Ilaria Missiroli, Sonia Modesti, Lorenzo Pedriali, Gaia Vezzani, Bianca Vitto, Veronica Angela Maria Antenori, Michele Lebiedzinska-Arciszewska, Magdalena Wieckowski, Mariusz R. Giorgi, Carlotta Pinton, Paolo |
dc.subject.por.fl_str_mv |
Autophagy; Calcium transfer apoptosis; Cancer; Diabetes; Inflammation and antiviral response; Lipid trafficking and metabolism; Mitochondrial dynamics; Neurodegenerative diseases; ROS |
topic |
Autophagy; Calcium transfer apoptosis; Cancer; Diabetes; Inflammation and antiviral response; Lipid trafficking and metabolism; Mitochondrial dynamics; Neurodegenerative diseases; ROS |
description |
Mitochondria and endoplasmic reticulum (ER) are fundamental in the control of cell physiology regulating several signal transduction pathways. They continuously communicate exchanging messages in their contact sites called MAMs (mitochondria-associated membranes). MAMs are specific microdomains acting as a platform for the sorting of vital and dangerous signals. In recent years increasing evidence reported that multiple scaffold proteins and regulatory factors localize to this subcellular fraction suggesting MAMs as hotspot signaling domains. In this review we describe the current knowledge about MAMs' dynamics and processes, which provided new correlations between MAMs' dysfunctions and human diseases. In fact, MAMs machinery is strictly connected with several pathologies, like neurodegeneration, diabetes and mainly cancer. These pathological events are characterized by alterations in the normal communication between ER and mitochondria, leading to deep metabolic defects that contribute to the progression of the diseases. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/book |
format |
book |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/95122 http://hdl.handle.net/10316/95122 https://doi.org/10.1016/bs.ircmb.2019.11.002 |
url |
http://hdl.handle.net/10316/95122 https://doi.org/10.1016/bs.ircmb.2019.11.002 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
9780128197448 https://www.sciencedirect.com/science/article/pii/S1937644819301042?via%3Dihub |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799134032403890176 |