Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island

Detalhes bibliográficos
Autor(a) principal: Berenguer, Anabela Gonçalves
Data de Publicação: 2014
Outros Autores: Oliveira, Susana, Fernandes, Ana Teresa, Rodrigues, Mariana, Ornelas, Pedro, Romeira, Diogo, Serrão, Tânia, Rosa, Alexandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/29716
Resumo: Background Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Global Initiative for Asthma (GINA) guidelines, established their sensitization profile, and measured their forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) indexes. Selected single nucleotide polymorphisms (SNPs) were analysed as potential markers for asthma susceptibility and severity in the interleukin 4 (IL4), interleukin 13 (IL13), beta-2-adrenergic receptor (ADRB2), a disintegrin and metalloprotease 33 (ADAM33), gasdermin-like (GSDML) and the signal transducer and activator of transcription 6 (STAT6) genes comparatively to a population reference set.
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spelling Genetic polymorphisms and asthma: findings from a case–control study in the Madeira islandGenetic polymorphismsasthmaMadeira IslandBackground Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Global Initiative for Asthma (GINA) guidelines, established their sensitization profile, and measured their forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) indexes. Selected single nucleotide polymorphisms (SNPs) were analysed as potential markers for asthma susceptibility and severity in the interleukin 4 (IL4), interleukin 13 (IL13), beta-2-adrenergic receptor (ADRB2), a disintegrin and metalloprotease 33 (ADAM33), gasdermin-like (GSDML) and the signal transducer and activator of transcription 6 (STAT6) genes comparatively to a population reference set.BiomedCentralRepositório ComumBerenguer, Anabela GonçalvesOliveira, SusanaFernandes, Ana TeresaRodrigues, MarianaOrnelas, PedroOrnelas, PedroRomeira, DiogoSerrão, TâniaRosa, Alexandra2019-09-18T15:00:34Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/29716engBiological Research 2014 47:40.0717-6287doi:10.1186/0717-6287-47-40info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-10T02:16:25Zoai:comum.rcaap.pt:10400.26/29716Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:34:23.405725Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island
title Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island
spellingShingle Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island
Berenguer, Anabela Gonçalves
Genetic polymorphisms
asthma
Madeira Island
title_short Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island
title_full Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island
title_fullStr Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island
title_full_unstemmed Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island
title_sort Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island
author Berenguer, Anabela Gonçalves
author_facet Berenguer, Anabela Gonçalves
Oliveira, Susana
Fernandes, Ana Teresa
Rodrigues, Mariana
Ornelas, Pedro
Romeira, Diogo
Serrão, Tânia
Rosa, Alexandra
author_role author
author2 Oliveira, Susana
Fernandes, Ana Teresa
Rodrigues, Mariana
Ornelas, Pedro
Romeira, Diogo
Serrão, Tânia
Rosa, Alexandra
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Berenguer, Anabela Gonçalves
Oliveira, Susana
Fernandes, Ana Teresa
Rodrigues, Mariana
Ornelas, Pedro
Ornelas, Pedro
Romeira, Diogo
Serrão, Tânia
Rosa, Alexandra
dc.subject.por.fl_str_mv Genetic polymorphisms
asthma
Madeira Island
topic Genetic polymorphisms
asthma
Madeira Island
description Background Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Global Initiative for Asthma (GINA) guidelines, established their sensitization profile, and measured their forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) indexes. Selected single nucleotide polymorphisms (SNPs) were analysed as potential markers for asthma susceptibility and severity in the interleukin 4 (IL4), interleukin 13 (IL13), beta-2-adrenergic receptor (ADRB2), a disintegrin and metalloprotease 33 (ADAM33), gasdermin-like (GSDML) and the signal transducer and activator of transcription 6 (STAT6) genes comparatively to a population reference set.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
2019-09-18T15:00:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/29716
url http://hdl.handle.net/10400.26/29716
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biological Research 2014 47:40.
0717-6287
doi:10.1186/0717-6287-47-40
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BiomedCentral
publisher.none.fl_str_mv BiomedCentral
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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