IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: an update

Detalhes bibliográficos
Autor(a) principal: Oliveira, Mariana L.
Data de Publicação: 2019
Outros Autores: Akkapeddi, Padma, Ribeiro, Daniel, Melão, Alice, Barata, João T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/52303
Resumo: © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)
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spelling IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: an updateB-cell acute lymphoblastic leukemiaIL-7RInterleukin 7JAK/STAT pathwayPI3K/Akt/mTOR pathwayT-ALLT-cell acute lymphoblastic leukemia© 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. In their absence, severe combined immunodeficiency occurs. By contrast, excessive IL-7/IL-7R-mediated signaling can drive lymphoid leukemia development, disease acceleration and resistance to chemotherapy. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ultimately leading to the promotion of leukemia cell viability, cell cycle progression and growth. However, the contribution of each of these pathways towards particular functional outcomes is still not completely known and appears to differ between normal and malignant states. For example, IL-7 upregulates Bcl-2 in a PI3K/Akt/mTOR-dependent and STAT5-independent manner in T-ALL cells. This is a 'symmetric image' of what apparently happens in normal lymphoid cells, where PI3K/Akt/mTOR does not impact on Bcl-2 and regulates proliferation rather than survival. In this review, we provide an updated summary of the knowledge on IL-7/IL-7R-mediated signaling in the context of cancer, focusing mainly on T-cell acute lymphoblastic leukemia, where this axis has been more extensively studied.Publication costs were supported by LISBOA-01-0145-FEDER-007391, project cofunded by FEDER, through POR Lisboa2020 Programa Operacional Regional de Lisboa, PORTUGAL 2020, and Fundação para a Ciência e a Tecnologia (FCT, Portugal). The research work in JTB's lab related to the present review was supported by the grants FAPESP/20015/2014 and PTDC/MEC-HEM/31588/2017, from FCT; and by the consolidator grant ERC CoG-648455 from the European Research Council, under the European Union's Horizon 2020 research and innovation programme. JTB is an FCT investigator (consolidator). MLO is a LisbonBioMed PhD student and received a fellowship from FCT. PA received a PhD fellowship from the EU Marie Sklodowska-Curie ITN Protein Conjugates.ElsevierRepositório da Universidade de LisboaOliveira, Mariana L.Akkapeddi, PadmaRibeiro, DanielMelão, AliceBarata, João T.2022-04-12T13:45:44Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52303engAdv Biol Regul. 2019 Jan;71:88-962212-492610.1016/j.jbior.2018.09.0122212-4934info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:57:27Zoai:repositorio.ul.pt:10451/52303Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:26.746940Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: an update
title IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: an update
spellingShingle IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: an update
Oliveira, Mariana L.
B-cell acute lymphoblastic leukemia
IL-7R
Interleukin 7
JAK/STAT pathway
PI3K/Akt/mTOR pathway
T-ALL
T-cell acute lymphoblastic leukemia
title_short IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: an update
title_full IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: an update
title_fullStr IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: an update
title_full_unstemmed IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: an update
title_sort IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: an update
author Oliveira, Mariana L.
author_facet Oliveira, Mariana L.
Akkapeddi, Padma
Ribeiro, Daniel
Melão, Alice
Barata, João T.
author_role author
author2 Akkapeddi, Padma
Ribeiro, Daniel
Melão, Alice
Barata, João T.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Oliveira, Mariana L.
Akkapeddi, Padma
Ribeiro, Daniel
Melão, Alice
Barata, João T.
dc.subject.por.fl_str_mv B-cell acute lymphoblastic leukemia
IL-7R
Interleukin 7
JAK/STAT pathway
PI3K/Akt/mTOR pathway
T-ALL
T-cell acute lymphoblastic leukemia
topic B-cell acute lymphoblastic leukemia
IL-7R
Interleukin 7
JAK/STAT pathway
PI3K/Akt/mTOR pathway
T-ALL
T-cell acute lymphoblastic leukemia
description © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2022-04-12T13:45:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/52303
url http://hdl.handle.net/10451/52303
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Adv Biol Regul. 2019 Jan;71:88-96
2212-4926
10.1016/j.jbior.2018.09.012
2212-4934
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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