The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissue

Detalhes bibliográficos
Autor(a) principal: Fuss, M. C.
Data de Publicação: 2015
Outros Autores: Ellis-Gibbings, L., Jones, D. B., Brunger, M. J., Blanco, Francisco J., Muñoz, A., Limão-Vieira, P., García, García
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1063/1.4921810
Resumo: Sem PDF. This research was supported by the Australian Research Council (ARC) through its Centres of Excellence Program. D.B.J. thanks the ARC for provision of a Discovery Early Career Researcher Award. We also acknowledge the support of the Spanish Ministerio de Economia y Competitivad under Project No. FIS 2012-31230 and the European Union COST Actions (MP1002 and CM1301). P.L.V. acknowledges the Portuguese Foundation for Science and Technology (FCT-MEC) through research grants PTDC/FIS-ATO/1832/2012, UID/FIS/00068/2013, and SFRH/BSAB/105792/2014. P.L.V. also acknowledges his Visiting Professor position at Flinders University, Adelaide, South Australia.
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spelling The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissueA comparative studyLOW-ENERGY-ELECTRONMONTE-CARLO-SIMULATIONMOMENTUM SPECTROSCOPYPOSITRON TRANSPORTTRACKSSCATTERINGRANGEBENZENESYSTEMSLIQUIDPhysics and Astronomy(all)Sem PDF. This research was supported by the Australian Research Council (ARC) through its Centres of Excellence Program. D.B.J. thanks the ARC for provision of a Discovery Early Career Researcher Award. We also acknowledge the support of the Spanish Ministerio de Economia y Competitivad under Project No. FIS 2012-31230 and the European Union COST Actions (MP1002 and CM1301). P.L.V. acknowledges the Portuguese Foundation for Science and Technology (FCT-MEC) through research grants PTDC/FIS-ATO/1832/2012, UID/FIS/00068/2013, and SFRH/BSAB/105792/2014. P.L.V. also acknowledges his Visiting Professor position at Flinders University, Adelaide, South Australia.Water is often used as the medium for characterizing the effects of radiation on living tissue. However, in this study, charged-particle track simulations are employed to quantify the induced physicochemical and potential biological implications when a primary ionising particle with energy 10 keV strikes a medium made up entirely of water or pyrimidine. Note that pyrimidine was chosen as the DNA/RNA bases cytosine, thymine, and uracil can be considered pyrimidine derivatives. This study aims to assess the influence of the choice of medium on the charged-particle transport, and identify how appropriate it is to use water as the default medium to describe the effects of ionising radiation on living tissue. Based on the respective electron interaction cross sections, we provide a model, which allows the study of radiation effects not only in terms of energy deposition (absorbed dose and stopping power) but also in terms of the number of induced molecular processes. Results of these parameters for water and pyrimidine are presented and compared.CeFITec – Centro de Física e Investigação TecnológicaDF – Departamento de FísicaRUNFuss, M. C.Ellis-Gibbings, L.Jones, D. B.Brunger, M. J.Blanco, Francisco J.Muñoz, A.Limão-Vieira, P.García, García2017-09-01T22:05:20Z2015-06-072015-06-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1063/1.4921810eng0021-8979PURE: 2896982http://www.scopus.com/inward/record.url?scp=84930406093&partnerID=8YFLogxKhttps://doi.org/10.1063/1.4921810info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:27:28Zoai:run.unl.pt:10362/23024Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:27:28Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissue
A comparative study
title The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissue
spellingShingle The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissue
Fuss, M. C.
LOW-ENERGY-ELECTRON
MONTE-CARLO-SIMULATION
MOMENTUM SPECTROSCOPY
POSITRON TRANSPORT
TRACKS
SCATTERING
RANGE
BENZENE
SYSTEMS
LIQUID
Physics and Astronomy(all)
title_short The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissue
title_full The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissue
title_fullStr The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissue
title_full_unstemmed The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissue
title_sort The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissue
author Fuss, M. C.
author_facet Fuss, M. C.
Ellis-Gibbings, L.
Jones, D. B.
Brunger, M. J.
Blanco, Francisco J.
Muñoz, A.
Limão-Vieira, P.
García, García
author_role author
author2 Ellis-Gibbings, L.
Jones, D. B.
Brunger, M. J.
Blanco, Francisco J.
Muñoz, A.
Limão-Vieira, P.
García, García
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv CeFITec – Centro de Física e Investigação Tecnológica
DF – Departamento de Física
RUN
dc.contributor.author.fl_str_mv Fuss, M. C.
Ellis-Gibbings, L.
Jones, D. B.
Brunger, M. J.
Blanco, Francisco J.
Muñoz, A.
Limão-Vieira, P.
García, García
dc.subject.por.fl_str_mv LOW-ENERGY-ELECTRON
MONTE-CARLO-SIMULATION
MOMENTUM SPECTROSCOPY
POSITRON TRANSPORT
TRACKS
SCATTERING
RANGE
BENZENE
SYSTEMS
LIQUID
Physics and Astronomy(all)
topic LOW-ENERGY-ELECTRON
MONTE-CARLO-SIMULATION
MOMENTUM SPECTROSCOPY
POSITRON TRANSPORT
TRACKS
SCATTERING
RANGE
BENZENE
SYSTEMS
LIQUID
Physics and Astronomy(all)
description Sem PDF. This research was supported by the Australian Research Council (ARC) through its Centres of Excellence Program. D.B.J. thanks the ARC for provision of a Discovery Early Career Researcher Award. We also acknowledge the support of the Spanish Ministerio de Economia y Competitivad under Project No. FIS 2012-31230 and the European Union COST Actions (MP1002 and CM1301). P.L.V. acknowledges the Portuguese Foundation for Science and Technology (FCT-MEC) through research grants PTDC/FIS-ATO/1832/2012, UID/FIS/00068/2013, and SFRH/BSAB/105792/2014. P.L.V. also acknowledges his Visiting Professor position at Flinders University, Adelaide, South Australia.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-07
2015-06-07T00:00:00Z
2017-09-01T22:05:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1063/1.4921810
url https://doi.org/10.1063/1.4921810
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0021-8979
PURE: 2896982
http://www.scopus.com/inward/record.url?scp=84930406093&partnerID=8YFLogxK
https://doi.org/10.1063/1.4921810
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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