Exposure to heavy metals and red blood cell parameters in children: a systematic review of observational studies

Detalhes bibliográficos
Autor(a) principal: Capitão, Carolina
Data de Publicação: 2022
Outros Autores: Martins, Raquel, Santos, Osvaldo, Bicho, Manuel, Szigeti, Tamás, Katsonouri, Andromachi, Bocca, Beatrice, Ruggieri, Flavia, Wasowicz, Wojciech, Tolonen, Hanna, Virgolino, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/54744
Resumo: © 2022 Capitão, Martins, Santos, Bicho, Szigeti, Katsonouri, Bocca, Ruggieri, Wasowicz, Tolonen and Virgolino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Exposure to heavy metals and red blood cell parameters in children: a systematic review of observational studiesHBM4EUBiomonitoringHematologyErythrocyte indicesChild© 2022 Capitão, Martins, Santos, Bicho, Szigeti, Katsonouri, Bocca, Ruggieri, Wasowicz, Tolonen and Virgolino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Background: Mechanistic studies show that heavy metals interfere with the hematopoietic system by inhibiting key enzymes, which could lead to anemia. However, the link between children’s exposure and red blood cell (RBC) parameters has been inconsistent. We aimed to summarize evidence on human studies exploring the association between exposure to lead, mercury, cadmium, arsenic, and chromium VI and RBC parameters in children. Methods: Following the PRISMA guidelines, we searched PubMed, Scopus, and Web of Science databases for studies published between January 2010 and April 2022. Eligible papers included human observational studies that directly assessed exposure (internal dose) to the heavy metals under study and RBC parameters in participants aged ≤18 years. We excluded studies using hospital-based samples. Study quality was assessed using the National Institutes of Health’s Quality Assessment Tools for Cohort and Cross-Sectional Studies. We synthesized the evidence using vote counting based on the direction of the relationship. Results: Out of 6,652 retrieved papers, we included a total of 38 (33 assessing lead, four mercury, two cadmium, and two arsenic; chromium VI was not assessed in any included paper). More than half of the studies were conducted in Asia. We found evidence of a positive relationship between lead concentration and hemoglobin (proportion of studies reporting negative relationships = 0.750; 95% Confidence Interval (CI) 0.583, 0.874) and mean corpuscular hemoglobin (0.875; 95% CI 0.546, 0.986), and a positive relationship with red cell distribution width (0.000; 95%CI 0.000, 0.379). When considering only good-quality studies (24% of the Pb studies), only the relationship with hemoglobin levels remained (0.875; 95% CI: 0.546, 0.986). Conclusion: We found evidence of a negative relationship between lead concentration and hemoglobin and mean corpuscular hemoglobin and of a positive relationship with red cell distribution width in children. We also identified a need to conduct more studies in European countries. Future studies should use standardized practices and make eorts to increase study quality, namely by conducting comprehensive longitudinal studies. Our findings support the need to take further actions to limit heavy metal exposure during childhood.This work was developed under the HBM4EU initiative, funded by the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 733032.FrontiersRepositório da Universidade de LisboaCapitão, CarolinaMartins, RaquelSantos, OsvaldoBicho, ManuelSzigeti, TamásKatsonouri, AndromachiBocca, BeatriceRuggieri, FlaviaWasowicz, WojciechTolonen, HannaVirgolino, Ana2022-10-11T16:02:41Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54744engCapitão C, Martins R, Santos O, Bicho M, Szigeti T, Katsonouri A, Bocca B, Ruggieri F, Wasowicz W, Tolonen H and Virgolino A (2022) Exposure to heavy metals and red blood cell parameters in children: A systematic review of observational studies. Front. Pediatr. 10:92123910.3389/fped.2022.9212392296-2360info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:01:17Zoai:repositorio.ul.pt:10451/54744Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:30.121402Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Exposure to heavy metals and red blood cell parameters in children: a systematic review of observational studies
title Exposure to heavy metals and red blood cell parameters in children: a systematic review of observational studies
spellingShingle Exposure to heavy metals and red blood cell parameters in children: a systematic review of observational studies
Capitão, Carolina
HBM4EU
Biomonitoring
Hematology
Erythrocyte indices
Child
title_short Exposure to heavy metals and red blood cell parameters in children: a systematic review of observational studies
title_full Exposure to heavy metals and red blood cell parameters in children: a systematic review of observational studies
title_fullStr Exposure to heavy metals and red blood cell parameters in children: a systematic review of observational studies
title_full_unstemmed Exposure to heavy metals and red blood cell parameters in children: a systematic review of observational studies
title_sort Exposure to heavy metals and red blood cell parameters in children: a systematic review of observational studies
author Capitão, Carolina
author_facet Capitão, Carolina
Martins, Raquel
Santos, Osvaldo
Bicho, Manuel
Szigeti, Tamás
Katsonouri, Andromachi
Bocca, Beatrice
Ruggieri, Flavia
Wasowicz, Wojciech
Tolonen, Hanna
Virgolino, Ana
author_role author
author2 Martins, Raquel
Santos, Osvaldo
Bicho, Manuel
Szigeti, Tamás
Katsonouri, Andromachi
Bocca, Beatrice
Ruggieri, Flavia
Wasowicz, Wojciech
Tolonen, Hanna
Virgolino, Ana
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Capitão, Carolina
Martins, Raquel
Santos, Osvaldo
Bicho, Manuel
Szigeti, Tamás
Katsonouri, Andromachi
Bocca, Beatrice
Ruggieri, Flavia
Wasowicz, Wojciech
Tolonen, Hanna
Virgolino, Ana
dc.subject.por.fl_str_mv HBM4EU
Biomonitoring
Hematology
Erythrocyte indices
Child
topic HBM4EU
Biomonitoring
Hematology
Erythrocyte indices
Child
description © 2022 Capitão, Martins, Santos, Bicho, Szigeti, Katsonouri, Bocca, Ruggieri, Wasowicz, Tolonen and Virgolino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-11T16:02:41Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54744
url http://hdl.handle.net/10451/54744
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Capitão C, Martins R, Santos O, Bicho M, Szigeti T, Katsonouri A, Bocca B, Ruggieri F, Wasowicz W, Tolonen H and Virgolino A (2022) Exposure to heavy metals and red blood cell parameters in children: A systematic review of observational studies. Front. Pediatr. 10:921239
10.3389/fped.2022.921239
2296-2360
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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