Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries

Detalhes bibliográficos
Autor(a) principal: Tavares, Ana Maria
Data de Publicação: 2022
Outros Autores: Viegas, Susana, Louro, Henriqueta, Göen, Thomas, Santonen, Tiina, Luijten, Mirjam, Kortenkamp, Andreas, Silva, Maria João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8389
Resumo: This article belongs to the Special Issue Human Biomonitoring in Health Risk Assessment: Current Practices and Recommendations for the Future.
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spelling Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European CountriesEnvironmental GenotoxicityHuman Biomonitoring (HBM)European Human Biomonitoring Initiative (HBM4EU)Co-exposureWorkplaceMixture Risk Assessment (MRA)Genotoxicidade AmbientalThis article belongs to the Special Issue Human Biomonitoring in Health Risk Assessment: Current Practices and Recommendations for the Future.Hexavalent chromium (Cr(VI)), nickel (Ni) and polycyclic aromatic hydrocarbons (PAHs) are genotoxic co-occurring lung carcinogens whose occupational health risk is still understudied. This study, conducted within the European Human Biomonitoring Initiative (HBM4EU), aimed at performing a mixtures risk assessment (MRA) based on published human biomonitoring (HBM) data from Cr(VI), Ni and/or PAHs occupational co-exposure in Europe. After data extraction, Risk Quotient (RQ) and Sum of Risk Quotients (SRQ) were calculated for binary and ternary mixtures to characterise the risk. Most selected articles measured urinary levels of Cr and Ni and a SRQ > 1 was obtained for co-exposure levels in welding activities, showing that there is concern regarding co-exposure to these substances. Similarly, co-exposure to mixtures of Cr(VI), Ni and PAHs in waste incineration settings resulted in SRQ > 1. In some studies, a low risk was estimated based on the single substances’ exposure level (RQ < 1), but the mixture was considered of concern (SRQ > 1), highlighting the relevance of considering exposure to the mixture rather than to its single components. Overall, this study points out the need of using a MRA based on HBM data as a more realistic approach to assess and manage the risk at the workplace, in order to protect workers’ health.This research was funded by European Unions’ Horizon 2020 research and innovation Programme under grant agreement No 733032 HBM4EU and co-funded by UIDP/00009/2020; UIDB/00009/2020 (Centre for Toxicogenomics and Human Health—ToxOmics, FCT).MDPIRepositório Científico do Instituto Nacional de SaúdeTavares, Ana MariaViegas, SusanaLouro, HenriquetaGöen, ThomasSantonen, TiinaLuijten, MirjamKortenkamp, AndreasSilva, Maria João2022-12-09T15:12:58Z2022-07-292022-07-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8389engToxics. 2022 Jul 29;10(8):431. doi: 10.3390/toxics100804312305-630410.3390/toxics10080431info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:29Zoai:repositorio.insa.pt:10400.18/8389Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:56.717047Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries
title Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries
spellingShingle Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries
Tavares, Ana Maria
Environmental Genotoxicity
Human Biomonitoring (HBM)
European Human Biomonitoring Initiative (HBM4EU)
Co-exposure
Workplace
Mixture Risk Assessment (MRA)
Genotoxicidade Ambiental
title_short Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries
title_full Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries
title_fullStr Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries
title_full_unstemmed Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries
title_sort Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries
author Tavares, Ana Maria
author_facet Tavares, Ana Maria
Viegas, Susana
Louro, Henriqueta
Göen, Thomas
Santonen, Tiina
Luijten, Mirjam
Kortenkamp, Andreas
Silva, Maria João
author_role author
author2 Viegas, Susana
Louro, Henriqueta
Göen, Thomas
Santonen, Tiina
Luijten, Mirjam
Kortenkamp, Andreas
Silva, Maria João
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Tavares, Ana Maria
Viegas, Susana
Louro, Henriqueta
Göen, Thomas
Santonen, Tiina
Luijten, Mirjam
Kortenkamp, Andreas
Silva, Maria João
dc.subject.por.fl_str_mv Environmental Genotoxicity
Human Biomonitoring (HBM)
European Human Biomonitoring Initiative (HBM4EU)
Co-exposure
Workplace
Mixture Risk Assessment (MRA)
Genotoxicidade Ambiental
topic Environmental Genotoxicity
Human Biomonitoring (HBM)
European Human Biomonitoring Initiative (HBM4EU)
Co-exposure
Workplace
Mixture Risk Assessment (MRA)
Genotoxicidade Ambiental
description This article belongs to the Special Issue Human Biomonitoring in Health Risk Assessment: Current Practices and Recommendations for the Future.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-09T15:12:58Z
2022-07-29
2022-07-29T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8389
url http://hdl.handle.net/10400.18/8389
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Toxics. 2022 Jul 29;10(8):431. doi: 10.3390/toxics10080431
2305-6304
10.3390/toxics10080431
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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