The association between 25-hydroxyvitamin d concentration and telomere length in the very-old

Detalhes bibliográficos
Autor(a) principal: Hakeem, Sarah
Data de Publicação: 2021
Outros Autores: Mendonça, Nuno, Aspray, Terry, Kingston, Andrew, Martin-Ruiz, Carmen, Robinson, Louise, Hill, Tom R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/129667
Resumo: Funding Information: Funding: The Newcastle 85+ study was jointly funded by the Medical Research Council and Biotechnology and Biomedical Science Research Council (G0500997), now part of UK Research and Innovation (UKRI) in addition to the Newcastle Healthcare Charity. The following waves were funded by the Dunhill Medical Trust (R124/0509), Newcastle University, UK Medical Research Council and the British Heart Foundation. Overall, the project was supported by National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. This particular analysis (vitamin D and telomere length) received no additional external funding. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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spelling The association between 25-hydroxyvitamin d concentration and telomere length in the very-oldThe newcastle 85+ studyAgeingTelomere lengthVitamin DFood ScienceNutrition and DieteticsFunding Information: Funding: The Newcastle 85+ study was jointly funded by the Medical Research Council and Biotechnology and Biomedical Science Research Council (G0500997), now part of UK Research and Innovation (UKRI) in addition to the Newcastle Healthcare Charity. The following waves were funded by the Dunhill Medical Trust (R124/0509), Newcastle University, UK Medical Research Council and the British Heart Foundation. Overall, the project was supported by National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. This particular analysis (vitamin D and telomere length) received no additional external funding. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.(1) Introduction: vitamin D may maintain the telomere length, either directly or via the inflammation effect and/or modulating the rate of cell proliferation. Whilst results from crosssectional studies investigating the association between 25(OH)D concentration and telomere length have been mixed, there is a dearth of data from prospective studies which have assessed these associations. This study aimed to examine the association between 25(OH)D concentration in plasma and telomere length in blood cells in very-old adults (≥85 years old) at baseline, 18 months and 36 months by controlling for related lifestyle factors. (2) Methodology: our prospective cohort study comprised 775 participants from the Newcastle 85+ Study who had 25(OH)D measurements at baseline. Plasma 25(OH)D was stratified as <25 nmol/L (low), 25–50 nmol/L (moderate) and >50 nmol/L (high). Peripheral blood mononuclear cell telomere length was measured by quantitative real-time polymerase chain reaction at baseline, 18 and 36 months from baseline. (3) Results: a positive significant association was found between 25(OH)D concentration and telomere length amongst very-old participants at baseline (95% CI = 12.0–110.3, B = 61.2 ± 5.0, p = 0.015). This association was negative at 18 months (95% CI = −59.9–−7.5, B = −33.7 ± 13.3, p = 0.012) but was non-significant at 36 months. (4) Conclusion: Circulating 25(OH)D concentration shows inconsistent relationships with telomere length over time in very-old (85+ year old) adults.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSCentro de Estudos de Doenças Crónicas (CEDOC)RUNHakeem, SarahMendonça, NunoAspray, TerryKingston, AndrewMartin-Ruiz, CarmenRobinson, LouiseHill, Tom R.2021-12-22T23:25:51Z2021-122021-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/129667eng1422-8599PURE: 35412790https://doi.org/10.3390/nu13124341info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:08:44Zoai:run.unl.pt:10362/129667Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:46:36.442572Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The association between 25-hydroxyvitamin d concentration and telomere length in the very-old
The newcastle 85+ study
title The association between 25-hydroxyvitamin d concentration and telomere length in the very-old
spellingShingle The association between 25-hydroxyvitamin d concentration and telomere length in the very-old
Hakeem, Sarah
Ageing
Telomere length
Vitamin D
Food Science
Nutrition and Dietetics
title_short The association between 25-hydroxyvitamin d concentration and telomere length in the very-old
title_full The association between 25-hydroxyvitamin d concentration and telomere length in the very-old
title_fullStr The association between 25-hydroxyvitamin d concentration and telomere length in the very-old
title_full_unstemmed The association between 25-hydroxyvitamin d concentration and telomere length in the very-old
title_sort The association between 25-hydroxyvitamin d concentration and telomere length in the very-old
author Hakeem, Sarah
author_facet Hakeem, Sarah
Mendonça, Nuno
Aspray, Terry
Kingston, Andrew
Martin-Ruiz, Carmen
Robinson, Louise
Hill, Tom R.
author_role author
author2 Mendonça, Nuno
Aspray, Terry
Kingston, Andrew
Martin-Ruiz, Carmen
Robinson, Louise
Hill, Tom R.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Hakeem, Sarah
Mendonça, Nuno
Aspray, Terry
Kingston, Andrew
Martin-Ruiz, Carmen
Robinson, Louise
Hill, Tom R.
dc.subject.por.fl_str_mv Ageing
Telomere length
Vitamin D
Food Science
Nutrition and Dietetics
topic Ageing
Telomere length
Vitamin D
Food Science
Nutrition and Dietetics
description Funding Information: Funding: The Newcastle 85+ study was jointly funded by the Medical Research Council and Biotechnology and Biomedical Science Research Council (G0500997), now part of UK Research and Innovation (UKRI) in addition to the Newcastle Healthcare Charity. The following waves were funded by the Dunhill Medical Trust (R124/0509), Newcastle University, UK Medical Research Council and the British Heart Foundation. Overall, the project was supported by National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. This particular analysis (vitamin D and telomere length) received no additional external funding. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-22T23:25:51Z
2021-12
2021-12-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/129667
url http://hdl.handle.net/10362/129667
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1422-8599
PURE: 35412790
https://doi.org/10.3390/nu13124341
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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