The association between 25-hydroxyvitamin d concentration and disability trajectories in very old adults

Detalhes bibliográficos
Autor(a) principal: Hakeem, Sarah
Data de Publicação: 2020
Outros Autores: Mendonca, Nuno, Aspray, Terry, Kingston, Andrew, Ruiz-Martin, Carmen, Jagger, Carol, Mathers, John C., Duncan, Rachel, Hill, Tom R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/104325
Resumo: Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate’ 25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25–50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.
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spelling The association between 25-hydroxyvitamin d concentration and disability trajectories in very old adultsThe newcastle 85+ studyDisabilityVery old adultsVitamin D statusFood ScienceNutrition and DieteticsBackground: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate’ 25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25–50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSCentro de Estudos de Doenças Crónicas (CEDOC)RUNHakeem, SarahMendonca, NunoAspray, TerryKingston, AndrewRuiz-Martin, CarmenJagger, CarolMathers, John C.Duncan, RachelHill, Tom R.2020-09-18T22:49:37Z2020-092020-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://hdl.handle.net/10362/104325eng1422-8599PURE: 19895392https://doi.org/10.3390/nu12092742info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:49:53Zoai:run.unl.pt:10362/104325Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:40:12.389715Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The association between 25-hydroxyvitamin d concentration and disability trajectories in very old adults
The newcastle 85+ study
title The association between 25-hydroxyvitamin d concentration and disability trajectories in very old adults
spellingShingle The association between 25-hydroxyvitamin d concentration and disability trajectories in very old adults
Hakeem, Sarah
Disability
Very old adults
Vitamin D status
Food Science
Nutrition and Dietetics
title_short The association between 25-hydroxyvitamin d concentration and disability trajectories in very old adults
title_full The association between 25-hydroxyvitamin d concentration and disability trajectories in very old adults
title_fullStr The association between 25-hydroxyvitamin d concentration and disability trajectories in very old adults
title_full_unstemmed The association between 25-hydroxyvitamin d concentration and disability trajectories in very old adults
title_sort The association between 25-hydroxyvitamin d concentration and disability trajectories in very old adults
author Hakeem, Sarah
author_facet Hakeem, Sarah
Mendonca, Nuno
Aspray, Terry
Kingston, Andrew
Ruiz-Martin, Carmen
Jagger, Carol
Mathers, John C.
Duncan, Rachel
Hill, Tom R.
author_role author
author2 Mendonca, Nuno
Aspray, Terry
Kingston, Andrew
Ruiz-Martin, Carmen
Jagger, Carol
Mathers, John C.
Duncan, Rachel
Hill, Tom R.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Hakeem, Sarah
Mendonca, Nuno
Aspray, Terry
Kingston, Andrew
Ruiz-Martin, Carmen
Jagger, Carol
Mathers, John C.
Duncan, Rachel
Hill, Tom R.
dc.subject.por.fl_str_mv Disability
Very old adults
Vitamin D status
Food Science
Nutrition and Dietetics
topic Disability
Very old adults
Vitamin D status
Food Science
Nutrition and Dietetics
description Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate’ 25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25–50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.
publishDate 2020
dc.date.none.fl_str_mv 2020-09-18T22:49:37Z
2020-09
2020-09-01T00:00:00Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/104325
url http://hdl.handle.net/10362/104325
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1422-8599
PURE: 19895392
https://doi.org/10.3390/nu12092742
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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