Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/9976 |
Resumo: | Urinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange juice) in rat bladder cancer chemoprevention and as therapeutic agent, on a rat model of urinary bladder carcinogenesis induced with N-butyl-N-(4-hydroxybutyl) nitrosamine. Results indicate that chitooligosaccharides may have a preventive effect on bladder cancer development and a curative effect upon established bladder tumors, dependent on the concentration ingested 500 mg/kg b.w., every three days, showed capacity to inhibit and prevent the proliferation of bladder cancer; however, this was associated with secondary effects such as hypercholesterolemia and hypertriglyceridemia. The use of lower doses (50 and 250 mg/kg b.w.) showed only therapeutic effects. It is further suggested that this antitumor effect might be due to its expected anti-inflammatory action, as well as by mechanisms not directly dependent of COX-2 inhibition, such as cellular proliferation control and improvement in antioxidant profile. |
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Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis modelChitosansBladder cancerChemopreventionChitooligosaccharidesUrinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange juice) in rat bladder cancer chemoprevention and as therapeutic agent, on a rat model of urinary bladder carcinogenesis induced with N-butyl-N-(4-hydroxybutyl) nitrosamine. Results indicate that chitooligosaccharides may have a preventive effect on bladder cancer development and a curative effect upon established bladder tumors, dependent on the concentration ingested 500 mg/kg b.w., every three days, showed capacity to inhibit and prevent the proliferation of bladder cancer; however, this was associated with secondary effects such as hypercholesterolemia and hypertriglyceridemia. The use of lower doses (50 and 250 mg/kg b.w.) showed only therapeutic effects. It is further suggested that this antitumor effect might be due to its expected anti-inflammatory action, as well as by mechanisms not directly dependent of COX-2 inhibition, such as cellular proliferation control and improvement in antioxidant profile.MDPI - Multidisciplinary Digital Publishing InstituteVeritati - Repositório Institucional da Universidade Católica PortuguesaFernandes, João C.Sereno, JoséGarrido, PatriciaParada, BelmiroCunha, Maria F. X.Reis, FlávioPintado, Manuela E.Santos-Silva, Alice2013-01-28T12:16:13Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/9976engFERNANDES, João C... [et al.] - Inhibition of Bladder Tumor Growth by Chitooligosaccharides in an Experimental Carcinogenesis Model. Marine Drugs. ISSN 1660-3397. Vol. 10, n.º 12 (2012), p. 2661-26751660-339710.3390/md10122661WOS:000312607700004info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-06T12:05:00Zoai:repositorio.ucp.pt:10400.14/9976Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-06T12:05Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model |
title |
Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model |
spellingShingle |
Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model Fernandes, João C. Chitosans Bladder cancer Chemoprevention Chitooligosaccharides |
title_short |
Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model |
title_full |
Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model |
title_fullStr |
Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model |
title_full_unstemmed |
Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model |
title_sort |
Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model |
author |
Fernandes, João C. |
author_facet |
Fernandes, João C. Sereno, José Garrido, Patricia Parada, Belmiro Cunha, Maria F. X. Reis, Flávio Pintado, Manuela E. Santos-Silva, Alice |
author_role |
author |
author2 |
Sereno, José Garrido, Patricia Parada, Belmiro Cunha, Maria F. X. Reis, Flávio Pintado, Manuela E. Santos-Silva, Alice |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Fernandes, João C. Sereno, José Garrido, Patricia Parada, Belmiro Cunha, Maria F. X. Reis, Flávio Pintado, Manuela E. Santos-Silva, Alice |
dc.subject.por.fl_str_mv |
Chitosans Bladder cancer Chemoprevention Chitooligosaccharides |
topic |
Chitosans Bladder cancer Chemoprevention Chitooligosaccharides |
description |
Urinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange juice) in rat bladder cancer chemoprevention and as therapeutic agent, on a rat model of urinary bladder carcinogenesis induced with N-butyl-N-(4-hydroxybutyl) nitrosamine. Results indicate that chitooligosaccharides may have a preventive effect on bladder cancer development and a curative effect upon established bladder tumors, dependent on the concentration ingested 500 mg/kg b.w., every three days, showed capacity to inhibit and prevent the proliferation of bladder cancer; however, this was associated with secondary effects such as hypercholesterolemia and hypertriglyceridemia. The use of lower doses (50 and 250 mg/kg b.w.) showed only therapeutic effects. It is further suggested that this antitumor effect might be due to its expected anti-inflammatory action, as well as by mechanisms not directly dependent of COX-2 inhibition, such as cellular proliferation control and improvement in antioxidant profile. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012 2012-01-01T00:00:00Z 2013-01-28T12:16:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/9976 |
url |
http://hdl.handle.net/10400.14/9976 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
FERNANDES, João C... [et al.] - Inhibition of Bladder Tumor Growth by Chitooligosaccharides in an Experimental Carcinogenesis Model. Marine Drugs. ISSN 1660-3397. Vol. 10, n.º 12 (2012), p. 2661-2675 1660-3397 10.3390/md10122661 WOS:000312607700004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI - Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
MDPI - Multidisciplinary Digital Publishing Institute |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
_version_ |
1817546740804354048 |