Numerical and analytical study of drug release from a biodegradable viscoelastic platform
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/45269 https://doi.org/10.1002/mma.3375 |
Resumo: | A mathematical model to simulate drug delivery from a viscoelastic erodible matrix is presented in this paper. The drug is initially distributed in the matrix that is in contact with water. The entrance of water in the material changes the molecular weight, and bulk erosion can be developed depending on how fast this entrance is and how fast degradation occurs. The viscoelastic properties of the matrix also change in the presence of water as the molecular weight changes. The model is represented by a system of quasi-linear partial differential equations that take into account different phenomena: the uptake of water, the decreasing of the molecular weight, the viscoelastic behavior, the dissolution of the solid drug, and the delivery of the dissolved drug. Numerical simulations illustrating the behavior of the model are included. |
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Numerical and analytical study of drug release from a biodegradable viscoelastic platformA mathematical model to simulate drug delivery from a viscoelastic erodible matrix is presented in this paper. The drug is initially distributed in the matrix that is in contact with water. The entrance of water in the material changes the molecular weight, and bulk erosion can be developed depending on how fast this entrance is and how fast degradation occurs. The viscoelastic properties of the matrix also change in the presence of water as the molecular weight changes. The model is represented by a system of quasi-linear partial differential equations that take into account different phenomena: the uptake of water, the decreasing of the molecular weight, the viscoelastic behavior, the dissolution of the solid drug, and the delivery of the dissolved drug. Numerical simulations illustrating the behavior of the model are included.Wiley2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/45269http://hdl.handle.net/10316/45269https://doi.org/10.1002/mma.3375https://doi.org/10.1002/mma.3375enghttp://onlinelibrary.wiley.com/doi/10.1002/mma.3375/abstractAzhdari, EbrahimFerreira, José AugustoOliveira, Paula deSilva, Pascoalinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-06-29T10:02:48Zoai:estudogeral.uc.pt:10316/45269Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:53:22.064622Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Numerical and analytical study of drug release from a biodegradable viscoelastic platform |
title |
Numerical and analytical study of drug release from a biodegradable viscoelastic platform |
spellingShingle |
Numerical and analytical study of drug release from a biodegradable viscoelastic platform Azhdari, Ebrahim |
title_short |
Numerical and analytical study of drug release from a biodegradable viscoelastic platform |
title_full |
Numerical and analytical study of drug release from a biodegradable viscoelastic platform |
title_fullStr |
Numerical and analytical study of drug release from a biodegradable viscoelastic platform |
title_full_unstemmed |
Numerical and analytical study of drug release from a biodegradable viscoelastic platform |
title_sort |
Numerical and analytical study of drug release from a biodegradable viscoelastic platform |
author |
Azhdari, Ebrahim |
author_facet |
Azhdari, Ebrahim Ferreira, José Augusto Oliveira, Paula de Silva, Pascoal |
author_role |
author |
author2 |
Ferreira, José Augusto Oliveira, Paula de Silva, Pascoal |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Azhdari, Ebrahim Ferreira, José Augusto Oliveira, Paula de Silva, Pascoal |
description |
A mathematical model to simulate drug delivery from a viscoelastic erodible matrix is presented in this paper. The drug is initially distributed in the matrix that is in contact with water. The entrance of water in the material changes the molecular weight, and bulk erosion can be developed depending on how fast this entrance is and how fast degradation occurs. The viscoelastic properties of the matrix also change in the presence of water as the molecular weight changes. The model is represented by a system of quasi-linear partial differential equations that take into account different phenomena: the uptake of water, the decreasing of the molecular weight, the viscoelastic behavior, the dissolution of the solid drug, and the delivery of the dissolved drug. Numerical simulations illustrating the behavior of the model are included. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/45269 http://hdl.handle.net/10316/45269 https://doi.org/10.1002/mma.3375 https://doi.org/10.1002/mma.3375 |
url |
http://hdl.handle.net/10316/45269 https://doi.org/10.1002/mma.3375 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://onlinelibrary.wiley.com/doi/10.1002/mma.3375/abstract |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133820695347200 |