Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome-Review of Classical and New Compounds: Part-I

• Autor(a) principal: Vieira, Raquel
• Data de Publicação: 2019
• Outros Autores: Souto, Selma B., Sánchez-López, Elena, Machado, Ana López, Severino, Patrícia, Jose, Sajan, Santini, Antonello, Fortuna, A., García, Maria Luisa, Silva, Amelia M., Souto, Eliana B.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/107210; https://doi.org/10.3390/ph12040152
• topic: diabetes mellitus; metabolic syndrome; glucose-lowering agents; sugar-lowering oils; phytotherapy

Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia together with disturbances in the metabolism of carbohydrates, proteins and fat, which in general results from an insulin availability and need imbalance. In a great number of patients, marketed anti-glycemic agents have shown poor effectiveness in maintaining a long-term glycemic control, thus being associated with severe adverse effects and leading to an emerging interest in natural compounds (e.g., essential oils and other secondary plant metabolites, namely, flavonoid-rich compounds) as a novel approach for prevention, management and/or treatment of either non-insulin-dependent diabetes mellitus (T2DM, type 2 DM) and/or Metabolic Syndrome (MS). In this review, some of these promising glucose-lowering agents will be comprehensively discussed.