Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome - review of classical and new compounds: Part-I

Detalhes bibliográficos
Autor(a) principal: Vieira, Raquel
Data de Publicação: 2019
Outros Autores: Souto, Selma B., Sánchez-López, Elena, Machado, Ana López, Severino, Patricia, Jose, Sajan, Santini, Antonello, Fortuna, Ana, García, Maria Luisa, Silva, Amelia M., Souto, Eliana B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/61777
Resumo: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia together with disturbances in the metabolism of carbohydrates, proteins and fat, which in general results from an insulin availability and need imbalance. In a great number of patients, marketed anti-glycemic agents have shown poor effectiveness in maintaining a long-term glycemic control, thus being associated with severe adverse effects and leading to an emerging interest in natural compounds (e.g., essential oils and other secondary plant metabolites, namely, flavonoid-rich compounds) as a novel approach for prevention, management and/or treatment of either non-insulin-dependent diabetes mellitus (T2DM, type 2 DM) and/or Metabolic Syndrome (MS). In this review, some of these promising glucose-lowering agents will be comprehensively discussed.
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spelling Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome - review of classical and new compounds: Part-Idiabetes mellitusmetabolic syndromeglucose-lowering agentssugar-lowering oilsphytotherapyScience & TechnologyDiabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia together with disturbances in the metabolism of carbohydrates, proteins and fat, which in general results from an insulin availability and need imbalance. In a great number of patients, marketed anti-glycemic agents have shown poor effectiveness in maintaining a long-term glycemic control, thus being associated with severe adverse effects and leading to an emerging interest in natural compounds (e.g., essential oils and other secondary plant metabolites, namely, flavonoid-rich compounds) as a novel approach for prevention, management and/or treatment of either non-insulin-dependent diabetes mellitus (T2DM, type 2 DM) and/or Metabolic Syndrome (MS). In this review, some of these promising glucose-lowering agents will be comprehensively discussed.This work was financially supported by the Portuguese Science and Technology Foundation (FCT/MCT) and from European Funds (PRODER/COMPETE) under the project reference M-ERANET/0004/2015-PAIRED and UID/AGR/04033/2019 (CITAB), co-financed by FEDER, under the Partnership Agreement PT2020, and also by the Institute of Nanoscience and Nanotechnology under the project ART(2018).info:eu-repo/semantics/publishedVersionMultidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoVieira, RaquelSouto, Selma B.Sánchez-López, ElenaMachado, Ana LópezSeverino, PatriciaJose, SajanSantini, AntonelloFortuna, AnaGarcía, Maria LuisaSilva, Amelia M.Souto, Eliana B.2019-10-102019-10-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/61777engVieira, Raquel; Souto, Selma B.; Sánchez-López, Elena; Machado, Ana López; Severino, Patricia; Jose, Sajan; Santini, Antonello; Fortuna, Ana; García, Maria Luisa; Silva, Amelia M.; Souto, Eliana, Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic SyndromeReview of Classical and New Compounds: Part-I. Pharmaceuticals, 12(4), 152, 20191424-824710.3390/ph12040152info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:38:49Zoai:repositorium.sdum.uminho.pt:1822/61777Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:35:21.042455Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome - review of classical and new compounds: Part-I
title Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome - review of classical and new compounds: Part-I
spellingShingle Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome - review of classical and new compounds: Part-I
Vieira, Raquel
diabetes mellitus
metabolic syndrome
glucose-lowering agents
sugar-lowering oils
phytotherapy
Science & Technology
title_short Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome - review of classical and new compounds: Part-I
title_full Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome - review of classical and new compounds: Part-I
title_fullStr Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome - review of classical and new compounds: Part-I
title_full_unstemmed Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome - review of classical and new compounds: Part-I
title_sort Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome - review of classical and new compounds: Part-I
author Vieira, Raquel
author_facet Vieira, Raquel
Souto, Selma B.
Sánchez-López, Elena
Machado, Ana López
Severino, Patricia
Jose, Sajan
Santini, Antonello
Fortuna, Ana
García, Maria Luisa
Silva, Amelia M.
Souto, Eliana B.
author_role author
author2 Souto, Selma B.
Sánchez-López, Elena
Machado, Ana López
Severino, Patricia
Jose, Sajan
Santini, Antonello
Fortuna, Ana
García, Maria Luisa
Silva, Amelia M.
Souto, Eliana B.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Vieira, Raquel
Souto, Selma B.
Sánchez-López, Elena
Machado, Ana López
Severino, Patricia
Jose, Sajan
Santini, Antonello
Fortuna, Ana
García, Maria Luisa
Silva, Amelia M.
Souto, Eliana B.
dc.subject.por.fl_str_mv diabetes mellitus
metabolic syndrome
glucose-lowering agents
sugar-lowering oils
phytotherapy
Science & Technology
topic diabetes mellitus
metabolic syndrome
glucose-lowering agents
sugar-lowering oils
phytotherapy
Science & Technology
description Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia together with disturbances in the metabolism of carbohydrates, proteins and fat, which in general results from an insulin availability and need imbalance. In a great number of patients, marketed anti-glycemic agents have shown poor effectiveness in maintaining a long-term glycemic control, thus being associated with severe adverse effects and leading to an emerging interest in natural compounds (e.g., essential oils and other secondary plant metabolites, namely, flavonoid-rich compounds) as a novel approach for prevention, management and/or treatment of either non-insulin-dependent diabetes mellitus (T2DM, type 2 DM) and/or Metabolic Syndrome (MS). In this review, some of these promising glucose-lowering agents will be comprehensively discussed.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-10
2019-10-10T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/61777
url http://hdl.handle.net/1822/61777
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Vieira, Raquel; Souto, Selma B.; Sánchez-López, Elena; Machado, Ana López; Severino, Patricia; Jose, Sajan; Santini, Antonello; Fortuna, Ana; García, Maria Luisa; Silva, Amelia M.; Souto, Eliana, Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic SyndromeReview of Classical and New Compounds: Part-I. Pharmaceuticals, 12(4), 152, 2019
1424-8247
10.3390/ph12040152
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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