Multidrug-Resistant Salmonella enterica Serovar Rissen Clusters Detected in Azores Archipelago, Portugal

Detalhes bibliográficos
Autor(a) principal: Silveira, Leonor
Data de Publicação: 2019
Outros Autores: Pinto, Miguel, Isidro, Joana, Pista, Ângela, Themudo, Patrícia, Vieira, Luís, Machado, Jorge, Gomes, João Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/6538
Resumo: Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31950026/
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spelling Multidrug-Resistant Salmonella enterica Serovar Rissen Clusters Detected in Azores Archipelago, PortugalSalmonellaNontyphoidal SalmonellaSalmonella entericaGastrointestinal InfectionsAzores ArchipelagoPortugalInfecções GastrointestinaisFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31950026/Gastrointestinal infections caused by nontyphoidal Salmonella (NTS) remain one of the main causes of foodborne illness worldwide. Within the multiple existing Salmonella enterica serovars, the serovar Rissen is rarely reported, particularly as a cause of human salmonellosis. Between 2015 and 2017, the Portuguese National Reference Laboratory of Gastrointestinal Infections observed an increase in the number of clinical cases caused by multidrug-resistant (MDR) S. enterica serovar Rissen, particularly from the Azores archipelago. In the present study, we analyzed by whole genome sequencing (WGS) all clinical, animal, food, and environmental isolates received up to 2017 in the Portuguese Reference Laboratories. As such, through a wgMLST-based gene-by-gene analysis, we aimed to identify potential epidemiological clusters linking clinical and samples from multiple sources, while gaining insight into the genetic diversity of S. enterica serovar Rissen. We also investigated the genetic basis driving the observed multidrug resistance. By integrating 60 novel genomes with all publicly available serovar Rissen genomes, we observed a low degree of genetic diversity within this serovar. Nevertheless, the majority of Portuguese isolates showed high degree of genetic relatedness and a potential link to pork production. An in-depth analysis of these isolates revealed the existence of two major clusters from the Azores archipelago composed of MDR isolates, most of which were resistant to at least five antimicrobials. Considering the well-known spread of MDR between gastrointestinal bacteria, the identification of MDR circulating clones should constitute an alert to public health authorities. Finally, this study constitutes the starting point for the implementation of the "One Health" approach for Salmonella surveillance in Portugal.This work was partially funded by the GenomePT project (POCI-01-0145- FEDER-022184), supported by COMPETE 2020–Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), and Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and by the Fundação para a Ciência e a Tecnologia (FCT)HindawiRepositório Científico do Instituto Nacional de SaúdeSilveira, LeonorPinto, MiguelIsidro, JoanaPista, ÂngelaThemudo, PatríciaVieira, LuísMachado, JorgeGomes, João Paulo2020-04-28T14:18:57Z2019-12-142019-12-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6538engInt J Genomics. 2019 Dec 14;2019:1860275. doi: 10.1155/2019/1860275. eCollection 2019. [Epub ahead of print]2314-436X10.1155/2019/1860275info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:43Zoai:repositorio.insa.pt:10400.18/6538Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:34.688736Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Multidrug-Resistant Salmonella enterica Serovar Rissen Clusters Detected in Azores Archipelago, Portugal
title Multidrug-Resistant Salmonella enterica Serovar Rissen Clusters Detected in Azores Archipelago, Portugal
spellingShingle Multidrug-Resistant Salmonella enterica Serovar Rissen Clusters Detected in Azores Archipelago, Portugal
Silveira, Leonor
Salmonella
Nontyphoidal Salmonella
Salmonella enterica
Gastrointestinal Infections
Azores Archipelago
Portugal
Infecções Gastrointestinais
title_short Multidrug-Resistant Salmonella enterica Serovar Rissen Clusters Detected in Azores Archipelago, Portugal
title_full Multidrug-Resistant Salmonella enterica Serovar Rissen Clusters Detected in Azores Archipelago, Portugal
title_fullStr Multidrug-Resistant Salmonella enterica Serovar Rissen Clusters Detected in Azores Archipelago, Portugal
title_full_unstemmed Multidrug-Resistant Salmonella enterica Serovar Rissen Clusters Detected in Azores Archipelago, Portugal
title_sort Multidrug-Resistant Salmonella enterica Serovar Rissen Clusters Detected in Azores Archipelago, Portugal
author Silveira, Leonor
author_facet Silveira, Leonor
Pinto, Miguel
Isidro, Joana
Pista, Ângela
Themudo, Patrícia
Vieira, Luís
Machado, Jorge
Gomes, João Paulo
author_role author
author2 Pinto, Miguel
Isidro, Joana
Pista, Ângela
Themudo, Patrícia
Vieira, Luís
Machado, Jorge
Gomes, João Paulo
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Silveira, Leonor
Pinto, Miguel
Isidro, Joana
Pista, Ângela
Themudo, Patrícia
Vieira, Luís
Machado, Jorge
Gomes, João Paulo
dc.subject.por.fl_str_mv Salmonella
Nontyphoidal Salmonella
Salmonella enterica
Gastrointestinal Infections
Azores Archipelago
Portugal
Infecções Gastrointestinais
topic Salmonella
Nontyphoidal Salmonella
Salmonella enterica
Gastrointestinal Infections
Azores Archipelago
Portugal
Infecções Gastrointestinais
description Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31950026/
publishDate 2019
dc.date.none.fl_str_mv 2019-12-14
2019-12-14T00:00:00Z
2020-04-28T14:18:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/6538
url http://hdl.handle.net/10400.18/6538
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Genomics. 2019 Dec 14;2019:1860275. doi: 10.1155/2019/1860275. eCollection 2019. [Epub ahead of print]
2314-436X
10.1155/2019/1860275
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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