Non-coding RNAs and HIV: viral manipulation of host dark matter to shape the cellular environment

Detalhes bibliográficos
Autor(a) principal: Barichievy, Samantha
Data de Publicação: 2015
Outros Autores: Naidoo, Jerolen, Mhlanga, Musa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/53194
Resumo: Copyright © 2015 Barichievy, Naidoo and Mhlanga. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Non-coding RNAs and HIV: viral manipulation of host dark matter to shape the cellular environmentHIV-1ApoptosisDouble strand breaksHost–pathogen interactionsImmune evasionLong non-coding RNAMicroRNAsCopyright © 2015 Barichievy, Naidoo and Mhlanga. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.On October 28th 1943 Winston Churchill said "we shape our buildings, and afterward our buildings shape us" (Humes, 1994). Churchill was pondering how and when to rebuild the British House of Commons, which had been destroyed by enemy bombs on May 10th 1941. The old House had been small and insufficient to hold all its members, but was restored to its original form in 1950 in order to recapture the "convenience and dignity" that the building had shaped into its parliamentary members. The circular loop whereby buildings or dwellings are shaped and go on to shape those that reside in them is also true of pathogens and their hosts. As obligate parasites, pathogens need to alter their cellular host environments to ensure survival. Typically pathogens modify cellular transcription profiles and in doing so, the pathogen in turn is affected, thereby closing the loop. As key orchestrators of gene expression, non-coding RNAs provide a vast and extremely precise set of tools for pathogens to target in order to shape the cellular environment. This review will focus on host non-coding RNAs that are manipulated by the infamous intracellular pathogen, the human immunodeficiency virus (HIV). We will briefly describe both short and long host non-coding RNAs and discuss how HIV gains control of these factors to ensure widespread dissemination throughout the host as well as the establishment of lifelong, chronic infection.FrontiersRepositório da Universidade de LisboaBarichievy, SamanthaNaidoo, JerolenMhlanga, Musa2022-05-26T16:13:05Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/53194engFront Genet. 2015 Mar 26;6:10810.3389/fgene.2015.001081664-8021info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:58:52Zoai:repositorio.ul.pt:10451/53194Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:04:09.551211Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Non-coding RNAs and HIV: viral manipulation of host dark matter to shape the cellular environment
title Non-coding RNAs and HIV: viral manipulation of host dark matter to shape the cellular environment
spellingShingle Non-coding RNAs and HIV: viral manipulation of host dark matter to shape the cellular environment
Barichievy, Samantha
HIV-1
Apoptosis
Double strand breaks
Host–pathogen interactions
Immune evasion
Long non-coding RNA
MicroRNAs
title_short Non-coding RNAs and HIV: viral manipulation of host dark matter to shape the cellular environment
title_full Non-coding RNAs and HIV: viral manipulation of host dark matter to shape the cellular environment
title_fullStr Non-coding RNAs and HIV: viral manipulation of host dark matter to shape the cellular environment
title_full_unstemmed Non-coding RNAs and HIV: viral manipulation of host dark matter to shape the cellular environment
title_sort Non-coding RNAs and HIV: viral manipulation of host dark matter to shape the cellular environment
author Barichievy, Samantha
author_facet Barichievy, Samantha
Naidoo, Jerolen
Mhlanga, Musa
author_role author
author2 Naidoo, Jerolen
Mhlanga, Musa
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Barichievy, Samantha
Naidoo, Jerolen
Mhlanga, Musa
dc.subject.por.fl_str_mv HIV-1
Apoptosis
Double strand breaks
Host–pathogen interactions
Immune evasion
Long non-coding RNA
MicroRNAs
topic HIV-1
Apoptosis
Double strand breaks
Host–pathogen interactions
Immune evasion
Long non-coding RNA
MicroRNAs
description Copyright © 2015 Barichievy, Naidoo and Mhlanga. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2022-05-26T16:13:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/53194
url http://hdl.handle.net/10451/53194
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Genet. 2015 Mar 26;6:108
10.3389/fgene.2015.00108
1664-8021
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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