Exposure to mercury and human reproductive health: a systematic review

Detalhes bibliográficos
Autor(a) principal: Henriques, Magda Carvalho
Data de Publicação: 2019
Outros Autores: Loureiro, Susana, Fardilha, Margarida, Herdeiro, Maria Teresa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/29542
Resumo: Background Evidences from human and animal studies suggest that reproductive function may be affected by mercury. The aim of this review was to explore the mercury influence on human fertility. Methods A systematic search was made in PubMED for papers published between 1975–2017, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results Increased mercury levels were associated with infertility or subfertility status. Further, infertile subjects with unexplained infertility showed higher levels of mercury in hair, blood and urine than fertile ones. Mercury exposure induced sperm DNA damage and abnormal sperm morphology and motility. Additionally, mercury levels were related with higher incidence of menstrual and hormonal disorders and increased rates of adverse reproductive outcomes. Conclusions Our review showed that mercury negatively impacts human reproduction, affecting the reproductive and endocrine systems in both male and female. However, the molecular mechanisms underlying the mercury-associated decline on fertility remains unknown.
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spelling Exposure to mercury and human reproductive health: a systematic reviewEpidemiologyHuman fertilityMercury exposureReproductionSystematic reviewBackground Evidences from human and animal studies suggest that reproductive function may be affected by mercury. The aim of this review was to explore the mercury influence on human fertility. Methods A systematic search was made in PubMED for papers published between 1975–2017, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results Increased mercury levels were associated with infertility or subfertility status. Further, infertile subjects with unexplained infertility showed higher levels of mercury in hair, blood and urine than fertile ones. Mercury exposure induced sperm DNA damage and abnormal sperm morphology and motility. Additionally, mercury levels were related with higher incidence of menstrual and hormonal disorders and increased rates of adverse reproductive outcomes. Conclusions Our review showed that mercury negatively impacts human reproduction, affecting the reproductive and endocrine systems in both male and female. However, the molecular mechanisms underlying the mercury-associated decline on fertility remains unknown.Elsevier2020-10-21T17:28:11Z2019-04-01T00:00:00Z2019-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/29542eng0890-623810.1016/j.reprotox.2019.02.012Henriques, Magda CarvalhoLoureiro, SusanaFardilha, MargaridaHerdeiro, Maria Teresainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:56:31Zoai:ria.ua.pt:10773/29542Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:01:36.531249Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Exposure to mercury and human reproductive health: a systematic review
title Exposure to mercury and human reproductive health: a systematic review
spellingShingle Exposure to mercury and human reproductive health: a systematic review
Henriques, Magda Carvalho
Epidemiology
Human fertility
Mercury exposure
Reproduction
Systematic review
title_short Exposure to mercury and human reproductive health: a systematic review
title_full Exposure to mercury and human reproductive health: a systematic review
title_fullStr Exposure to mercury and human reproductive health: a systematic review
title_full_unstemmed Exposure to mercury and human reproductive health: a systematic review
title_sort Exposure to mercury and human reproductive health: a systematic review
author Henriques, Magda Carvalho
author_facet Henriques, Magda Carvalho
Loureiro, Susana
Fardilha, Margarida
Herdeiro, Maria Teresa
author_role author
author2 Loureiro, Susana
Fardilha, Margarida
Herdeiro, Maria Teresa
author2_role author
author
author
dc.contributor.author.fl_str_mv Henriques, Magda Carvalho
Loureiro, Susana
Fardilha, Margarida
Herdeiro, Maria Teresa
dc.subject.por.fl_str_mv Epidemiology
Human fertility
Mercury exposure
Reproduction
Systematic review
topic Epidemiology
Human fertility
Mercury exposure
Reproduction
Systematic review
description Background Evidences from human and animal studies suggest that reproductive function may be affected by mercury. The aim of this review was to explore the mercury influence on human fertility. Methods A systematic search was made in PubMED for papers published between 1975–2017, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results Increased mercury levels were associated with infertility or subfertility status. Further, infertile subjects with unexplained infertility showed higher levels of mercury in hair, blood and urine than fertile ones. Mercury exposure induced sperm DNA damage and abnormal sperm morphology and motility. Additionally, mercury levels were related with higher incidence of menstrual and hormonal disorders and increased rates of adverse reproductive outcomes. Conclusions Our review showed that mercury negatively impacts human reproduction, affecting the reproductive and endocrine systems in both male and female. However, the molecular mechanisms underlying the mercury-associated decline on fertility remains unknown.
publishDate 2019
dc.date.none.fl_str_mv 2019-04-01T00:00:00Z
2019-04
2020-10-21T17:28:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/29542
url http://hdl.handle.net/10773/29542
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0890-6238
10.1016/j.reprotox.2019.02.012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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