Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/18482 |
Resumo: | The study of ocular drug delivery systems has been one of the most covered topics in drug delivery research. One potential drug carrier solution is the use of materials that are already commercially available in ophthalmic lenses for the correction of refractive errors. In this study, we present a diffusion-based mathematical model in which the parameters can be adjusted based on experimental results obtained under controlled conditions. The model allows for the design of multi-layered therapeutic ophthalmic lenses for controlled drug delivery. We show that the proper combination of materials with adequate drug diffusion coefficients, thicknesses and interfacial transport characteristics allows for the control of the delivery of drugs from multi-layered ophthalmic lenses, such that drug bursts can be minimized, and the release time can be maximized. As far as we know, this combination of a mathematical modelling approach with experimental validation of non-constant activity source lamellar structures, made of layers of different materials, accounting for the interface resistance to the drug diffusion, is a novel approach to the design of drug loaded multi-layered contact lenses. |
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Diffusion-based design of multi-layered ophthalmic lenses for controlled drug releaseOphthalmic lensesControlled drug releaseThe study of ocular drug delivery systems has been one of the most covered topics in drug delivery research. One potential drug carrier solution is the use of materials that are already commercially available in ophthalmic lenses for the correction of refractive errors. In this study, we present a diffusion-based mathematical model in which the parameters can be adjusted based on experimental results obtained under controlled conditions. The model allows for the design of multi-layered therapeutic ophthalmic lenses for controlled drug delivery. We show that the proper combination of materials with adequate drug diffusion coefficients, thicknesses and interfacial transport characteristics allows for the control of the delivery of drugs from multi-layered ophthalmic lenses, such that drug bursts can be minimized, and the release time can be maximized. As far as we know, this combination of a mathematical modelling approach with experimental validation of non-constant activity source lamellar structures, made of layers of different materials, accounting for the interface resistance to the drug diffusion, is a novel approach to the design of drug loaded multi-layered contact lenses.PLOSRepositório ComumPimenta, Andreia F. R.Serro, Ana PaulaParadiso, PatriziaSaramago, BenildeColaço, Rogério2017-06-07T09:27:38Z2016-12-01T00:00:00Z2016-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/18482engPimenta AFR, Serro AP, Paradiso P, Saramago B, ColacËo R (2016) Diffusion-Based Design of Multi-Layered Ophthalmic Lenses for Controlled Drug Release. PLoS ONE 11(12): e0167728. doi:10.1371/journal.pone.01677281932-620310.1371/journal.pone.0167728info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:52:52Zoai:comum.rcaap.pt:10400.26/18482Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:08:52.916815Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
title |
Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
spellingShingle |
Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release Pimenta, Andreia F. R. Ophthalmic lenses Controlled drug release |
title_short |
Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
title_full |
Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
title_fullStr |
Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
title_full_unstemmed |
Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
title_sort |
Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
author |
Pimenta, Andreia F. R. |
author_facet |
Pimenta, Andreia F. R. Serro, Ana Paula Paradiso, Patrizia Saramago, Benilde Colaço, Rogério |
author_role |
author |
author2 |
Serro, Ana Paula Paradiso, Patrizia Saramago, Benilde Colaço, Rogério |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Comum |
dc.contributor.author.fl_str_mv |
Pimenta, Andreia F. R. Serro, Ana Paula Paradiso, Patrizia Saramago, Benilde Colaço, Rogério |
dc.subject.por.fl_str_mv |
Ophthalmic lenses Controlled drug release |
topic |
Ophthalmic lenses Controlled drug release |
description |
The study of ocular drug delivery systems has been one of the most covered topics in drug delivery research. One potential drug carrier solution is the use of materials that are already commercially available in ophthalmic lenses for the correction of refractive errors. In this study, we present a diffusion-based mathematical model in which the parameters can be adjusted based on experimental results obtained under controlled conditions. The model allows for the design of multi-layered therapeutic ophthalmic lenses for controlled drug delivery. We show that the proper combination of materials with adequate drug diffusion coefficients, thicknesses and interfacial transport characteristics allows for the control of the delivery of drugs from multi-layered ophthalmic lenses, such that drug bursts can be minimized, and the release time can be maximized. As far as we know, this combination of a mathematical modelling approach with experimental validation of non-constant activity source lamellar structures, made of layers of different materials, accounting for the interface resistance to the drug diffusion, is a novel approach to the design of drug loaded multi-layered contact lenses. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-01T00:00:00Z 2016-12-01T00:00:00Z 2017-06-07T09:27:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/18482 |
url |
http://hdl.handle.net/10400.26/18482 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pimenta AFR, Serro AP, Paradiso P, Saramago B, ColacËo R (2016) Diffusion-Based Design of Multi-Layered Ophthalmic Lenses for Controlled Drug Release. PLoS ONE 11(12): e0167728. doi:10.1371/journal.pone.0167728 1932-6203 10.1371/journal.pone.0167728 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
PLOS |
publisher.none.fl_str_mv |
PLOS |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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