Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study

• Autor(a) principal: Simões, Margarida
• Data de Publicação: 2024
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10174/36809; https://doi.org/Simoes, M. P., Hodcroft, E. B., Simmonds, P., Albert, J., Alidjinou, E. K., Ambert-Balay, K., Andrés, C., Antón, A., Auvray, C., Bailly, J. L., Baldanti, F., Bastings, C., Beard, S., Pereira, C. B., Berginc, N., Bloemen, M., Blomqvist, S., Bosma, F., Böttcher, S., Bubba, L., … Benschop, K. S. M. (2024). Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study. The Journal of infectious diseases, jiae154. Advance online publication. https://doi.org/10.1093/infdis/jiae154; https://doi.org/10.1093/infdis/jiae154
• topic: enterovirus D68 (EV-D68); European Non-Polio Enterovirus Network (ENPEN); B3-derived lineages; surveillance

Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 and its clinical impact during the fall-winter season of 2021/22. From 19 European countries, 58 institutes reported 10,481 (6.8%) EV-positive samples of which 1,004 (9.6%) were identified as EV-D68 (852 respiratory samples). Clinical data was reported for 969 cases. 78.9% of infections were reported in children (0-5 years); 37.9% of cases were hospitalised. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases with six reported with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of two novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale EV-D68 European upsurge with severe clinical impact and the emergence of B3-derived lineages.