Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae:Ulva rigida and Gelidium microdon

Detalhes bibliográficos
Autor(a) principal: Madalena Silva
Data de Publicação: 2013
Outros Autores: Luís M. M. Vieira, Ana Paula Almeida, Artur M. S. Silva, Ana M. L. Seca, M. Carmo Barreto, Ana I. Neto, Madalena Pedro, Eugénia Pinto, Anake Kijjoa
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/81744
Resumo: The green macroalga Ulva rigida C. Agardh (Chlorophyta) and the red macroalga Gelidium microdon Kützing (Rhodophyta), collected from the Azorean archipelago, were investigated for their secondary metabolites and their in vitro growth inhibitory effect on three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma), as well as for their antifungal and antibacterial activities. The methanol extract of U. rigida furnished isofucosterol (1), 7(E)-3β-hydroxy-5α,6α-epoxymegastigmane (2) and (+)-dehydrovomifoliol (3) while the methanol extract of G. microdon yielded cholesterol (4) and lumichrome (5). The crude extracts of both macroalgae were found to be moderately active against the three cell lines whereas compound 1 showed a weak effect and compound 2 was inactive. The crude extracts of the two macroalgae were found to be moderately active against some fungi and bacteria while compounds 1 and 2 were inactive against all microorganisms tested.
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spelling Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae:Ulva rigida and Gelidium microdonCiências biológicas, Ciências biológicasBiological sciences, Biological sciencesThe green macroalga Ulva rigida C. Agardh (Chlorophyta) and the red macroalga Gelidium microdon Kützing (Rhodophyta), collected from the Azorean archipelago, were investigated for their secondary metabolites and their in vitro growth inhibitory effect on three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma), as well as for their antifungal and antibacterial activities. The methanol extract of U. rigida furnished isofucosterol (1), 7(E)-3β-hydroxy-5α,6α-epoxymegastigmane (2) and (+)-dehydrovomifoliol (3) while the methanol extract of G. microdon yielded cholesterol (4) and lumichrome (5). The crude extracts of both macroalgae were found to be moderately active against the three cell lines whereas compound 1 showed a weak effect and compound 2 was inactive. The crude extracts of the two macroalgae were found to be moderately active against some fungi and bacteria while compounds 1 and 2 were inactive against all microorganisms tested.20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/81744por2332-263210.4172/2332-2632.1000102Madalena SilvaLuís M. M. VieiraAna Paula AlmeidaArtur M. S. SilvaAna M. L. SecaM. Carmo BarretoAna I. NetoMadalena PedroEugénia PintoAnake Kijjoainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:35:47Zoai:repositorio-aberto.up.pt:10216/81744Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:04:46.089119Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae:Ulva rigida and Gelidium microdon
title Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae:Ulva rigida and Gelidium microdon
spellingShingle Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae:Ulva rigida and Gelidium microdon
Madalena Silva
Ciências biológicas, Ciências biológicas
Biological sciences, Biological sciences
title_short Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae:Ulva rigida and Gelidium microdon
title_full Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae:Ulva rigida and Gelidium microdon
title_fullStr Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae:Ulva rigida and Gelidium microdon
title_full_unstemmed Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae:Ulva rigida and Gelidium microdon
title_sort Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae:Ulva rigida and Gelidium microdon
author Madalena Silva
author_facet Madalena Silva
Luís M. M. Vieira
Ana Paula Almeida
Artur M. S. Silva
Ana M. L. Seca
M. Carmo Barreto
Ana I. Neto
Madalena Pedro
Eugénia Pinto
Anake Kijjoa
author_role author
author2 Luís M. M. Vieira
Ana Paula Almeida
Artur M. S. Silva
Ana M. L. Seca
M. Carmo Barreto
Ana I. Neto
Madalena Pedro
Eugénia Pinto
Anake Kijjoa
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Madalena Silva
Luís M. M. Vieira
Ana Paula Almeida
Artur M. S. Silva
Ana M. L. Seca
M. Carmo Barreto
Ana I. Neto
Madalena Pedro
Eugénia Pinto
Anake Kijjoa
dc.subject.por.fl_str_mv Ciências biológicas, Ciências biológicas
Biological sciences, Biological sciences
topic Ciências biológicas, Ciências biológicas
Biological sciences, Biological sciences
description The green macroalga Ulva rigida C. Agardh (Chlorophyta) and the red macroalga Gelidium microdon Kützing (Rhodophyta), collected from the Azorean archipelago, were investigated for their secondary metabolites and their in vitro growth inhibitory effect on three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma), as well as for their antifungal and antibacterial activities. The methanol extract of U. rigida furnished isofucosterol (1), 7(E)-3β-hydroxy-5α,6α-epoxymegastigmane (2) and (+)-dehydrovomifoliol (3) while the methanol extract of G. microdon yielded cholesterol (4) and lumichrome (5). The crude extracts of both macroalgae were found to be moderately active against the three cell lines whereas compound 1 showed a weak effect and compound 2 was inactive. The crude extracts of the two macroalgae were found to be moderately active against some fungi and bacteria while compounds 1 and 2 were inactive against all microorganisms tested.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/81744
url https://hdl.handle.net/10216/81744
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 2332-2632
10.4172/2332-2632.1000102
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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