Mucosal delivery of liposome-chitosan nanoparticles complexes

Detalhes bibliográficos
Autor(a) principal: Carvalho, Edison Samir Mascarelhas
Data de Publicação: 2009
Outros Autores: Grenha, Ana, Remuñán-López, Carmen, Alonso, Maria José, Seijo, Begoña
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/2081
Resumo: Designing adequate drug carriers has long been a major challenge for those working in drug delivery. Since drug delivery strategies have evolved for mucosal delivery as the outstanding alternative to parenteral administration, many new drug delivery systems have been developed which evidence promising properties to address specific issues. Colloidal carriers, such as nanoparticles and liposomes, have been referred to as the most valuable approaches, but still have some limitations that can become more inconvenient as a function of the specific characteristics of administration routes. To overcome these limitations, we developed a new drug delivery system that results from the combination of chitosan nanoparticles and liposomes, in an approach of combining their advantages, while avoiding their individual limitations. These lipid/chitosan nanoparticle complexes are, thus, expected to protect the encapsulated drug from harsh environmental conditions, while concomitantly providing its controlled release. To prepare these assemblies, two different strategies have been applied: one focusing on the simple hydration of a previously formed dry lipid film with a suspension of chitosan nanoparticles, and the other relying on the lyophilization of both basic structures (nanoparticles and liposomes) with a subsequent step of hydration with water. The developed systems are able to provide a controlled release of the encapsulated model peptide, insulin, evidencing release profiles that are dependent on their lipid composition. Moreover, satisfactory in vivo results have been obtained, confirming the potential of these newly developed drug delivery systems as drug carriers through distinct mucosal routes.
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spelling Mucosal delivery of liposome-chitosan nanoparticles complexesLiposomesChitosanNanoparticlesMucosal deliveryDesigning adequate drug carriers has long been a major challenge for those working in drug delivery. Since drug delivery strategies have evolved for mucosal delivery as the outstanding alternative to parenteral administration, many new drug delivery systems have been developed which evidence promising properties to address specific issues. Colloidal carriers, such as nanoparticles and liposomes, have been referred to as the most valuable approaches, but still have some limitations that can become more inconvenient as a function of the specific characteristics of administration routes. To overcome these limitations, we developed a new drug delivery system that results from the combination of chitosan nanoparticles and liposomes, in an approach of combining their advantages, while avoiding their individual limitations. These lipid/chitosan nanoparticle complexes are, thus, expected to protect the encapsulated drug from harsh environmental conditions, while concomitantly providing its controlled release. To prepare these assemblies, two different strategies have been applied: one focusing on the simple hydration of a previously formed dry lipid film with a suspension of chitosan nanoparticles, and the other relying on the lyophilization of both basic structures (nanoparticles and liposomes) with a subsequent step of hydration with water. The developed systems are able to provide a controlled release of the encapsulated model peptide, insulin, evidencing release profiles that are dependent on their lipid composition. Moreover, satisfactory in vivo results have been obtained, confirming the potential of these newly developed drug delivery systems as drug carriers through distinct mucosal routes.Nejat DüzgüneşSapientiaCarvalho, Edison Samir MascarelhasGrenha, AnaRemuñán-López, CarmenAlonso, Maria JoséSeijo, Begoña2013-01-15T15:25:06Z20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/2081eng0076-6879AUT: AMG02212;info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:12:06Zoai:sapientia.ualg.pt:10400.1/2081Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:55:20.539317Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mucosal delivery of liposome-chitosan nanoparticles complexes
title Mucosal delivery of liposome-chitosan nanoparticles complexes
spellingShingle Mucosal delivery of liposome-chitosan nanoparticles complexes
Carvalho, Edison Samir Mascarelhas
Liposomes
Chitosan
Nanoparticles
Mucosal delivery
title_short Mucosal delivery of liposome-chitosan nanoparticles complexes
title_full Mucosal delivery of liposome-chitosan nanoparticles complexes
title_fullStr Mucosal delivery of liposome-chitosan nanoparticles complexes
title_full_unstemmed Mucosal delivery of liposome-chitosan nanoparticles complexes
title_sort Mucosal delivery of liposome-chitosan nanoparticles complexes
author Carvalho, Edison Samir Mascarelhas
author_facet Carvalho, Edison Samir Mascarelhas
Grenha, Ana
Remuñán-López, Carmen
Alonso, Maria José
Seijo, Begoña
author_role author
author2 Grenha, Ana
Remuñán-López, Carmen
Alonso, Maria José
Seijo, Begoña
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Carvalho, Edison Samir Mascarelhas
Grenha, Ana
Remuñán-López, Carmen
Alonso, Maria José
Seijo, Begoña
dc.subject.por.fl_str_mv Liposomes
Chitosan
Nanoparticles
Mucosal delivery
topic Liposomes
Chitosan
Nanoparticles
Mucosal delivery
description Designing adequate drug carriers has long been a major challenge for those working in drug delivery. Since drug delivery strategies have evolved for mucosal delivery as the outstanding alternative to parenteral administration, many new drug delivery systems have been developed which evidence promising properties to address specific issues. Colloidal carriers, such as nanoparticles and liposomes, have been referred to as the most valuable approaches, but still have some limitations that can become more inconvenient as a function of the specific characteristics of administration routes. To overcome these limitations, we developed a new drug delivery system that results from the combination of chitosan nanoparticles and liposomes, in an approach of combining their advantages, while avoiding their individual limitations. These lipid/chitosan nanoparticle complexes are, thus, expected to protect the encapsulated drug from harsh environmental conditions, while concomitantly providing its controlled release. To prepare these assemblies, two different strategies have been applied: one focusing on the simple hydration of a previously formed dry lipid film with a suspension of chitosan nanoparticles, and the other relying on the lyophilization of both basic structures (nanoparticles and liposomes) with a subsequent step of hydration with water. The developed systems are able to provide a controlled release of the encapsulated model peptide, insulin, evidencing release profiles that are dependent on their lipid composition. Moreover, satisfactory in vivo results have been obtained, confirming the potential of these newly developed drug delivery systems as drug carriers through distinct mucosal routes.
publishDate 2009
dc.date.none.fl_str_mv 2009
2009-01-01T00:00:00Z
2013-01-15T15:25:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/2081
url http://hdl.handle.net/10400.1/2081
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0076-6879
AUT: AMG02212;
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dc.publisher.none.fl_str_mv Nejat Düzgüneş
publisher.none.fl_str_mv Nejat Düzgüneş
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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