Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugal
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/3358 |
Resumo: | INTRODUCTION: Immune profile for influenza viruses is highly changeable over time. Serological studies can assess the prevalence of influenza, estimate the risk of infection, highlight asymptomatic infection rate and can also provide data on vaccine coverage. The aims of the study were to evaluate pre-existing cross-protection against influenza A(H3) drift viruses and to assess influenza immunity in the Portuguese population. MATERIALS AND METHODS: We developed a cross-sectional study based on a convenience sample of 626 sera collected during June 2014, covering all age groups, both gender and all administrative health regions of Portugal. Sera antibody titers for seasonal and new A(H3) drift influenza virus were evaluated by hemagglutination inhibition assay (HI). Seroprevalence to each seasonal influenza vaccine strain virus and to the new A(H3) drift circulating strain was estimated by age group, gender and region and compared with seasonal influenza-like illness (ILI) incidence rates before and after the study period. RESULTS: Our findings suggest that seroprevalences of influenza A(H3) (39.9%; 95% CI: 36.2-43.8) and A(H1)pdm09 (29.7%; 95% CI: 26.3-33.4) antibodies were higher than for influenza B, in line with high ILI incidence rates for A(H3) followed by A(H1)pdm09, during 2013/2014 season. Low pre-existing cross-protection against new A(H3) drift viruses were observed in A(H3) seropositive individuals (46%). Both against influenza A(H1)pdm09 and A(H3) seroprotection was highest in younger than 14-years old. Protective antibodies against influenza B were highest in those older than 65years old, especially for B/Yamagata lineage, 33.3% (95% CI: 25.7-41.9). Women showed a high seroprevalence to influenza, although without statistical significance, when compared to men. A significant decreasing trend in seroprotection from north to south regions of Portugal mainland was observed. CONCLUSIONS: Our results emphasize that low seroprotection increases the risk of influenza infection in the following winter season. Seroepidemiological studies can inform policy makers on the need for vaccination and additional preventive measures. |
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Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in PortugalAdolescentAdultAgedAged, 80 and overAntibodies, ViralChildChild, PreschoolCross-Sectional StudiesFemaleHemagglutination Inhibition TestsHumansIncidenceInfantInfant, NewbornInfluenza A virusInfluenza, HumanMaleMiddle AgedPortugalSeroepidemiologic StudiesYoung AdultCross ProtectionCHLC PAT CLININTRODUCTION: Immune profile for influenza viruses is highly changeable over time. Serological studies can assess the prevalence of influenza, estimate the risk of infection, highlight asymptomatic infection rate and can also provide data on vaccine coverage. The aims of the study were to evaluate pre-existing cross-protection against influenza A(H3) drift viruses and to assess influenza immunity in the Portuguese population. MATERIALS AND METHODS: We developed a cross-sectional study based on a convenience sample of 626 sera collected during June 2014, covering all age groups, both gender and all administrative health regions of Portugal. Sera antibody titers for seasonal and new A(H3) drift influenza virus were evaluated by hemagglutination inhibition assay (HI). Seroprevalence to each seasonal influenza vaccine strain virus and to the new A(H3) drift circulating strain was estimated by age group, gender and region and compared with seasonal influenza-like illness (ILI) incidence rates before and after the study period. RESULTS: Our findings suggest that seroprevalences of influenza A(H3) (39.9%; 95% CI: 36.2-43.8) and A(H1)pdm09 (29.7%; 95% CI: 26.3-33.4) antibodies were higher than for influenza B, in line with high ILI incidence rates for A(H3) followed by A(H1)pdm09, during 2013/2014 season. Low pre-existing cross-protection against new A(H3) drift viruses were observed in A(H3) seropositive individuals (46%). Both against influenza A(H1)pdm09 and A(H3) seroprotection was highest in younger than 14-years old. Protective antibodies against influenza B were highest in those older than 65years old, especially for B/Yamagata lineage, 33.3% (95% CI: 25.7-41.9). Women showed a high seroprevalence to influenza, although without statistical significance, when compared to men. A significant decreasing trend in seroprotection from north to south regions of Portugal mainland was observed. CONCLUSIONS: Our results emphasize that low seroprotection increases the risk of influenza infection in the following winter season. Seroepidemiological studies can inform policy makers on the need for vaccination and additional preventive measures.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEGuiomar, RPereira da Silva, SConde, PCristóvão, PMaia, ACPechirra, PRodrigues, APNunes, BMilho, LCoelho, APFernandes, ACaseiro, PRodrigues, FCorreia, LPereira-Vaz, JAlmeida, SBranquinho, PCôrte-Real, RViseu, RPeres, MJSanches, RDantas, FFreitas, LAndrade, GMaurílio, MCaldeira, FCabral Veloso, RMota-Vieira, LSoares, MCouto, ARBruges-Armas, JMouro Pinto, RSobrinho Simões, JCosta, MRGuimarães, JTMartins, LCunha, M2019-11-12T16:11:52Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3358engVaccine. 2017 Apr 11;35(16):2092-2099.10.1016/j.vaccine.2017.02.019info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:42:34Zoai:repositorio.chlc.min-saude.pt:10400.17/3358Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:40.574697Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugal |
title |
Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugal |
spellingShingle |
Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugal Guiomar, R Adolescent Adult Aged Aged, 80 and over Antibodies, Viral Child Child, Preschool Cross-Sectional Studies Female Hemagglutination Inhibition Tests Humans Incidence Infant Infant, Newborn Influenza A virus Influenza, Human Male Middle Aged Portugal Seroepidemiologic Studies Young Adult Cross Protection CHLC PAT CLIN |
title_short |
Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugal |
title_full |
Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugal |
title_fullStr |
Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugal |
title_full_unstemmed |
Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugal |
title_sort |
Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugal |
author |
Guiomar, R |
author_facet |
Guiomar, R Pereira da Silva, S Conde, P Cristóvão, P Maia, AC Pechirra, P Rodrigues, AP Nunes, B Milho, L Coelho, AP Fernandes, A Caseiro, P Rodrigues, F Correia, L Pereira-Vaz, J Almeida, S Branquinho, P Côrte-Real, R Viseu, R Peres, MJ Sanches, R Dantas, F Freitas, L Andrade, G Maurílio, M Caldeira, F Cabral Veloso, R Mota-Vieira, L Soares, M Couto, AR Bruges-Armas, J Mouro Pinto, R Sobrinho Simões, J Costa, MR Guimarães, JT Martins, L Cunha, M |
author_role |
author |
author2 |
Pereira da Silva, S Conde, P Cristóvão, P Maia, AC Pechirra, P Rodrigues, AP Nunes, B Milho, L Coelho, AP Fernandes, A Caseiro, P Rodrigues, F Correia, L Pereira-Vaz, J Almeida, S Branquinho, P Côrte-Real, R Viseu, R Peres, MJ Sanches, R Dantas, F Freitas, L Andrade, G Maurílio, M Caldeira, F Cabral Veloso, R Mota-Vieira, L Soares, M Couto, AR Bruges-Armas, J Mouro Pinto, R Sobrinho Simões, J Costa, MR Guimarães, JT Martins, L Cunha, M |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Guiomar, R Pereira da Silva, S Conde, P Cristóvão, P Maia, AC Pechirra, P Rodrigues, AP Nunes, B Milho, L Coelho, AP Fernandes, A Caseiro, P Rodrigues, F Correia, L Pereira-Vaz, J Almeida, S Branquinho, P Côrte-Real, R Viseu, R Peres, MJ Sanches, R Dantas, F Freitas, L Andrade, G Maurílio, M Caldeira, F Cabral Veloso, R Mota-Vieira, L Soares, M Couto, AR Bruges-Armas, J Mouro Pinto, R Sobrinho Simões, J Costa, MR Guimarães, JT Martins, L Cunha, M |
dc.subject.por.fl_str_mv |
Adolescent Adult Aged Aged, 80 and over Antibodies, Viral Child Child, Preschool Cross-Sectional Studies Female Hemagglutination Inhibition Tests Humans Incidence Infant Infant, Newborn Influenza A virus Influenza, Human Male Middle Aged Portugal Seroepidemiologic Studies Young Adult Cross Protection CHLC PAT CLIN |
topic |
Adolescent Adult Aged Aged, 80 and over Antibodies, Viral Child Child, Preschool Cross-Sectional Studies Female Hemagglutination Inhibition Tests Humans Incidence Infant Infant, Newborn Influenza A virus Influenza, Human Male Middle Aged Portugal Seroepidemiologic Studies Young Adult Cross Protection CHLC PAT CLIN |
description |
INTRODUCTION: Immune profile for influenza viruses is highly changeable over time. Serological studies can assess the prevalence of influenza, estimate the risk of infection, highlight asymptomatic infection rate and can also provide data on vaccine coverage. The aims of the study were to evaluate pre-existing cross-protection against influenza A(H3) drift viruses and to assess influenza immunity in the Portuguese population. MATERIALS AND METHODS: We developed a cross-sectional study based on a convenience sample of 626 sera collected during June 2014, covering all age groups, both gender and all administrative health regions of Portugal. Sera antibody titers for seasonal and new A(H3) drift influenza virus were evaluated by hemagglutination inhibition assay (HI). Seroprevalence to each seasonal influenza vaccine strain virus and to the new A(H3) drift circulating strain was estimated by age group, gender and region and compared with seasonal influenza-like illness (ILI) incidence rates before and after the study period. RESULTS: Our findings suggest that seroprevalences of influenza A(H3) (39.9%; 95% CI: 36.2-43.8) and A(H1)pdm09 (29.7%; 95% CI: 26.3-33.4) antibodies were higher than for influenza B, in line with high ILI incidence rates for A(H3) followed by A(H1)pdm09, during 2013/2014 season. Low pre-existing cross-protection against new A(H3) drift viruses were observed in A(H3) seropositive individuals (46%). Both against influenza A(H1)pdm09 and A(H3) seroprotection was highest in younger than 14-years old. Protective antibodies against influenza B were highest in those older than 65years old, especially for B/Yamagata lineage, 33.3% (95% CI: 25.7-41.9). Women showed a high seroprevalence to influenza, although without statistical significance, when compared to men. A significant decreasing trend in seroprotection from north to south regions of Portugal mainland was observed. CONCLUSIONS: Our results emphasize that low seroprotection increases the risk of influenza infection in the following winter season. Seroepidemiological studies can inform policy makers on the need for vaccination and additional preventive measures. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2019-11-12T16:11:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/3358 |
url |
http://hdl.handle.net/10400.17/3358 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Vaccine. 2017 Apr 11;35(16):2092-2099. 10.1016/j.vaccine.2017.02.019 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131302694223872 |