Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/4730 |
Resumo: | Em colaboração com a Rede Portuguesa de Laboratóros para o Diagnóstico da Gripe |
| id |
RCAP_032127ebc878af1659c11a6ab6c62f88 |
|---|---|
| oai_identifier_str |
oai:repositorio.insa.pt:10400.18/4730 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in PortugalInfluenzaCross-protectionSeroprevalenceSeroepidemiologic StudiesInfecções RespiratóriasEstados de Saúde e de DoençaEm colaboração com a Rede Portuguesa de Laboratóros para o Diagnóstico da GripeIntroduction: Immune profile for influenza viruses is highly changeable over time. Serological studies can assess the prevalence of influenza, estimate the risk of infection, highlight asymptomatic infection rate and can also provide data on vaccine coverage. The aims of the study were to evaluate pre-existing cross-protection against influenza A(H3) drift viruses and to assess influenza immunity in the Portuguese population. Materials and methods: We developed a cross-sectional study based on a convenience sample of 626 sera collected during June 2014, covering all age groups, both gender and all administrative health regions of Portugal. Sera antibody titers for seasonal and new A(H3) drift influenza virus were evaluated by hemagglutination inhibition assay (HI). Seroprevalence to each seasonal influenza vaccine strain virus and to the new A(H3) drift circulating strain was estimated by age group, gender and region and compared with seasonal influenza-like illness (ILI) incidence rates before and after the study period. Results: Our findings suggest that seroprevalences of influenza A(H3) (39.9%; 95% CI: 36.2–43.8) and A(H1)pdm09 (29.7%; 95% CI: 26.3–33.4) antibodies were higher than for influenza B, in line with high ILI incidence rates for A(H3) followed by A(H1)pdm09, during 2013/2014 season. Low pre-existing crossprotection against new A(H3) drift viruses were observed in A(H3) seropositive individuals (46%). Both against influenza A(H1)pdm09 and A(H3) seroprotection was highest in younger than 14-years old. Protective antibodies against influenza B were highest in those older than 65 years old, especially for B/Yamagata lineage, 33.3% (95% CI: 25.7–41.9). Women showed a high seroprevalence to influenza, although without statistical significance, when compared to men. A significant decreasing trend in seroprotection from north to south regions of Portugal mainland was observed. Conclusions: Our results emphasize that low seroprotection increases the risk of influenza infection in the following winter season. Seroepidemiological studies can inform policy makers on the need for vaccination and additional preventive measures.This work was supported by the National Institute of Health Doutor Ricardo Jorge, IP Lisbon, Portugal.ElsevierRepositório Científico do Instituto Nacional de SaúdeGuiomar, RaquelPereira da Silva, SusanaConde, PatríciaCristóvão, PaulaMaia, Ana CarinaPechirra, PedroRodrigues, Ana PaulaNunes, BaltazarMilho, LuísCoelho, Ana PaulaFernandes, AidaCaseiro, PaulaRodrigues, FernandoCorreia, LurdesPereira-Vaz, JoãoAlmeida, SofiaBranquinho, PaulaCôrte-Real, RitaViseu, ReginaPeres, Maria JoãoSanches, RaquelDantas, FilipaFreitas, LudovinaAndrade, GraçaMaurílio, ManuelCaldeira, FilomenaCabral Veloso, RitaMota-Vieira, LuísaSoares, MartaCouto, Ana RitaBruges-Armas, JácomeMouro Pinto, RitaSobrinho Simões, JoanaRosário Costa, MariaGuimarães, João TiagoMartins, LuísCunha, Mário2018-04-12T00:30:12Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4730engVaccine. 2017 Apr 11;35(16):2092-2099. doi: 10.1016/j.vaccine.2017.02.019. Epub 2017 Mar 18.0264-410Xhttp://dx.doi.org/10.1016/j.vaccine.2017.02.019info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:27Zoai:repositorio.insa.pt:10400.18/4730Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:27.370494Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal |
| title |
Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal |
| spellingShingle |
Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal Guiomar, Raquel Influenza Cross-protection Seroprevalence Seroepidemiologic Studies Infecções Respiratórias Estados de Saúde e de Doença |
| title_short |
Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal |
| title_full |
Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal |
| title_fullStr |
Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal |
| title_full_unstemmed |
Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal |
| title_sort |
Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal |
| author |
Guiomar, Raquel |
| author_facet |
Guiomar, Raquel Pereira da Silva, Susana Conde, Patrícia Cristóvão, Paula Maia, Ana Carina Pechirra, Pedro Rodrigues, Ana Paula Nunes, Baltazar Milho, Luís Coelho, Ana Paula Fernandes, Aida Caseiro, Paula Rodrigues, Fernando Correia, Lurdes Pereira-Vaz, João Almeida, Sofia Branquinho, Paula Côrte-Real, Rita Viseu, Regina Peres, Maria João Sanches, Raquel Dantas, Filipa Freitas, Ludovina Andrade, Graça Maurílio, Manuel Caldeira, Filomena Cabral Veloso, Rita Mota-Vieira, Luísa Soares, Marta Couto, Ana Rita Bruges-Armas, Jácome Mouro Pinto, Rita Sobrinho Simões, Joana Rosário Costa, Maria Guimarães, João Tiago Martins, Luís Cunha, Mário |
| author_role |
author |
| author2 |
Pereira da Silva, Susana Conde, Patrícia Cristóvão, Paula Maia, Ana Carina Pechirra, Pedro Rodrigues, Ana Paula Nunes, Baltazar Milho, Luís Coelho, Ana Paula Fernandes, Aida Caseiro, Paula Rodrigues, Fernando Correia, Lurdes Pereira-Vaz, João Almeida, Sofia Branquinho, Paula Côrte-Real, Rita Viseu, Regina Peres, Maria João Sanches, Raquel Dantas, Filipa Freitas, Ludovina Andrade, Graça Maurílio, Manuel Caldeira, Filomena Cabral Veloso, Rita Mota-Vieira, Luísa Soares, Marta Couto, Ana Rita Bruges-Armas, Jácome Mouro Pinto, Rita Sobrinho Simões, Joana Rosário Costa, Maria Guimarães, João Tiago Martins, Luís Cunha, Mário |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Guiomar, Raquel Pereira da Silva, Susana Conde, Patrícia Cristóvão, Paula Maia, Ana Carina Pechirra, Pedro Rodrigues, Ana Paula Nunes, Baltazar Milho, Luís Coelho, Ana Paula Fernandes, Aida Caseiro, Paula Rodrigues, Fernando Correia, Lurdes Pereira-Vaz, João Almeida, Sofia Branquinho, Paula Côrte-Real, Rita Viseu, Regina Peres, Maria João Sanches, Raquel Dantas, Filipa Freitas, Ludovina Andrade, Graça Maurílio, Manuel Caldeira, Filomena Cabral Veloso, Rita Mota-Vieira, Luísa Soares, Marta Couto, Ana Rita Bruges-Armas, Jácome Mouro Pinto, Rita Sobrinho Simões, Joana Rosário Costa, Maria Guimarães, João Tiago Martins, Luís Cunha, Mário |
| dc.subject.por.fl_str_mv |
Influenza Cross-protection Seroprevalence Seroepidemiologic Studies Infecções Respiratórias Estados de Saúde e de Doença |
| topic |
Influenza Cross-protection Seroprevalence Seroepidemiologic Studies Infecções Respiratórias Estados de Saúde e de Doença |
| description |
Em colaboração com a Rede Portuguesa de Laboratóros para o Diagnóstico da Gripe |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2018-04-12T00:30:12Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/4730 |
| url |
http://hdl.handle.net/10400.18/4730 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Vaccine. 2017 Apr 11;35(16):2092-2099. doi: 10.1016/j.vaccine.2017.02.019. Epub 2017 Mar 18. 0264-410X http://dx.doi.org/10.1016/j.vaccine.2017.02.019 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
| eu_rights_str_mv |
embargoedAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
|
| _version_ |
1799132133309022208 |