Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival

Detalhes bibliográficos
Autor(a) principal: Gama, Adelina
Data de Publicação: 2008
Outros Autores: Paredes, Joana, Gärtner, Fátima, Alves, Anabela, Schmitt, Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/61600
Resumo: Cadherin-catenin complexes play a critical role in intercellular adhesion, and their altered expression has been implicated in tumour progression. In this study, the expression of E-cadherin, P-cadherin and beta-catenin was analysed in 65 canine malignant mammary tumours and correlated with clinicopathological parameters, proliferation and survival. Reduction in E-cadherin expression was significantly associated with increased tumour size, high histological and invasion grades, lymph node metastasis and high mitotic index. Reduced beta-catenin expression was associated with high histological and invasion grades. Anomalous expression of P-cadherin was only associated with invasion. In 39 cases for which follow-up data were available, reduced E-cadherin and beta-catenin expression was significantly associated with shorter overall survival and disease free survival. Abnormal expression of adhesion molecules is a common phenomenon in canine mammary malignant tumours and may play a central role in tumour progression.
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spelling Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survivalAnimalsBiomarkers, TumorCadherinsDisease-Free SurvivalDog DiseasesDogsFemaleImmunohistochemistryLymph NodesLymphatic MetastasisMammary Neoplasms, AnimalNeoplasm InvasivenessPrognosisSurvival AnalysisBeta CateninGene Expression Regulation, NeoplasticCanineMammary tumoursE-cadherinP-cadherinβ-CateninScience & TechnologyCadherin-catenin complexes play a critical role in intercellular adhesion, and their altered expression has been implicated in tumour progression. In this study, the expression of E-cadherin, P-cadherin and beta-catenin was analysed in 65 canine malignant mammary tumours and correlated with clinicopathological parameters, proliferation and survival. Reduction in E-cadherin expression was significantly associated with increased tumour size, high histological and invasion grades, lymph node metastasis and high mitotic index. Reduced beta-catenin expression was associated with high histological and invasion grades. Anomalous expression of P-cadherin was only associated with invasion. In 39 cases for which follow-up data were available, reduced E-cadherin and beta-catenin expression was significantly associated with shorter overall survival and disease free survival. Abnormal expression of adhesion molecules is a common phenomenon in canine mammary malignant tumours and may play a central role in tumour progression.This work was supported by the Centro de Ciência Animal e Veterinária (CECAV) – University of Trás os Montes e Alto Douro (UTAD), Vila Real, Portugal and by Portuguese Science and Technology Foundation, Project POCTI/CVT/57795/2004.Elsevier 1Universidade do MinhoGama, AdelinaParedes, JoanaGärtner, FátimaAlves, AnabelaSchmitt, Fernando2008-072008-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/61600eng1090-02331532-297110.1016/j.tvjl.2007.05.02417631398info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-25T01:54:58Zoai:repositorium.sdum.uminho.pt:1822/61600Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-25T01:54:58Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival
title Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival
spellingShingle Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival
Gama, Adelina
Animals
Biomarkers, Tumor
Cadherins
Disease-Free Survival
Dog Diseases
Dogs
Female
Immunohistochemistry
Lymph Nodes
Lymphatic Metastasis
Mammary Neoplasms, Animal
Neoplasm Invasiveness
Prognosis
Survival Analysis
Beta Catenin
Gene Expression Regulation, Neoplastic
Canine
Mammary tumours
E-cadherin
P-cadherin
β-Catenin
Science & Technology
title_short Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival
title_full Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival
title_fullStr Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival
title_full_unstemmed Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival
title_sort Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival
author Gama, Adelina
author_facet Gama, Adelina
Paredes, Joana
Gärtner, Fátima
Alves, Anabela
Schmitt, Fernando
author_role author
author2 Paredes, Joana
Gärtner, Fátima
Alves, Anabela
Schmitt, Fernando
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Gama, Adelina
Paredes, Joana
Gärtner, Fátima
Alves, Anabela
Schmitt, Fernando
dc.subject.por.fl_str_mv Animals
Biomarkers, Tumor
Cadherins
Disease-Free Survival
Dog Diseases
Dogs
Female
Immunohistochemistry
Lymph Nodes
Lymphatic Metastasis
Mammary Neoplasms, Animal
Neoplasm Invasiveness
Prognosis
Survival Analysis
Beta Catenin
Gene Expression Regulation, Neoplastic
Canine
Mammary tumours
E-cadherin
P-cadherin
β-Catenin
Science & Technology
topic Animals
Biomarkers, Tumor
Cadherins
Disease-Free Survival
Dog Diseases
Dogs
Female
Immunohistochemistry
Lymph Nodes
Lymphatic Metastasis
Mammary Neoplasms, Animal
Neoplasm Invasiveness
Prognosis
Survival Analysis
Beta Catenin
Gene Expression Regulation, Neoplastic
Canine
Mammary tumours
E-cadherin
P-cadherin
β-Catenin
Science & Technology
description Cadherin-catenin complexes play a critical role in intercellular adhesion, and their altered expression has been implicated in tumour progression. In this study, the expression of E-cadherin, P-cadherin and beta-catenin was analysed in 65 canine malignant mammary tumours and correlated with clinicopathological parameters, proliferation and survival. Reduction in E-cadherin expression was significantly associated with increased tumour size, high histological and invasion grades, lymph node metastasis and high mitotic index. Reduced beta-catenin expression was associated with high histological and invasion grades. Anomalous expression of P-cadherin was only associated with invasion. In 39 cases for which follow-up data were available, reduced E-cadherin and beta-catenin expression was significantly associated with shorter overall survival and disease free survival. Abnormal expression of adhesion molecules is a common phenomenon in canine mammary malignant tumours and may play a central role in tumour progression.
publishDate 2008
dc.date.none.fl_str_mv 2008-07
2008-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/61600
url https://hdl.handle.net/1822/61600
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1090-0233
1532-2971
10.1016/j.tvjl.2007.05.024
17631398
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier 1
publisher.none.fl_str_mv Elsevier 1
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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