Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs

Detalhes bibliográficos
Autor(a) principal: Pereira, Karuza Maria Alves
Data de Publicação: 2010
Outros Autores: Amaral, Bruna Aguiar do, Santos, Bruna Rafaela Martins dos, Galvão, Hebel Cavalcanti, Freitas, Roseana de Almeida, Souza, Lelia Batista de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/21208
Resumo: OBJECTIVE: The aim was to analyze the expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs to determine their roles in cell differentiation processes and invasiveness compared with odontogenesis. STUDY DESIGN: Twenty-one ameloblastoma cases (16 solid and 5 unicystic tumors) and 5 tooth germs were submitted to the immunohistochemical detection of E-cadherin and beta-catenin. Immunoreactivity was evaluated using descriptive and semiquantitative analysis, investigating the location and intensity of staining. The Fisher exact test was performed, and P values of <.05 were considered to indicate statistical significance. RESULTS: There was no statistically significant difference in the expression of E-cadherin and beta-catenin between solid and unicystic ameloblastomas (P = .59; P = .63; respectively). The same was found when comparing solid and unicystic ameloblastomas with the tooth germs for both E-cadherin (P = .53; P = .44; respectively) and beta-catenin (P = .12; P = .16; respectively). Nuclear staining of beta-catenin was observed in only 4 cases (3 solid and 1 unicystic tumor). CONCLUSION: The results showed no differences in the expression of E-cadherin or beta-catenin between tooth germs and solid and unicystic ameloblastomas. The expression of these molecules seems mainly to be related to the process of cell differentiation.
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spelling Pereira, Karuza Maria AlvesAmaral, Bruna Aguiar doSantos, Bruna Rafaela Martins dosGalvão, Hebel CavalcantiFreitas, Roseana de AlmeidaSouza, Lelia Batista de2016-08-22T16:35:08Z2016-08-22T16:35:08Z2010PEREIRA, Karuza Maria Alves et al. Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, v. 109, n. 3, p. 425-431, 2010.https://repositorio.ufrn.br/jspui/handle/123456789/21208engImmunohistochemicalE-cadherinbeta-cateninameloblastomaImmunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOBJECTIVE: The aim was to analyze the expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs to determine their roles in cell differentiation processes and invasiveness compared with odontogenesis. STUDY DESIGN: Twenty-one ameloblastoma cases (16 solid and 5 unicystic tumors) and 5 tooth germs were submitted to the immunohistochemical detection of E-cadherin and beta-catenin. Immunoreactivity was evaluated using descriptive and semiquantitative analysis, investigating the location and intensity of staining. The Fisher exact test was performed, and P values of <.05 were considered to indicate statistical significance. RESULTS: There was no statistically significant difference in the expression of E-cadherin and beta-catenin between solid and unicystic ameloblastomas (P = .59; P = .63; respectively). The same was found when comparing solid and unicystic ameloblastomas with the tooth germs for both E-cadherin (P = .53; P = .44; respectively) and beta-catenin (P = .12; P = .16; respectively). Nuclear staining of beta-catenin was observed in only 4 cases (3 solid and 1 unicystic tumor). CONCLUSION: The results showed no differences in the expression of E-cadherin or beta-catenin between tooth germs and solid and unicystic ameloblastomas. The expression of these molecules seems mainly to be related to the process of cell differentiation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALImmunohistochemicalExpressionEcadherin_Pereira_2010.pdfImmunohistochemicalExpressionEcadherin_Pereira_2010.pdfapplication/pdf2096956https://repositorio.ufrn.br/bitstream/123456789/21208/1/ImmunohistochemicalExpressionEcadherin_Pereira_2010.pdf3c1c73c97c314e82ff5c8c389f1cea6fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81563https://repositorio.ufrn.br/bitstream/123456789/21208/2/license.txt2fca3d993fd069474a9dfb5156c39499MD52TEXTImmunohistochemical expression of E-cadherin and_2010.pdf.txtImmunohistochemical expression of E-cadherin and_2010.pdf.txtExtracted texttext/plain28966https://repositorio.ufrn.br/bitstream/123456789/21208/7/Immunohistochemical%20expression%20of%20E-cadherin%20and_2010.pdf.txt38958326d2fe6ffbc19b655bffb3bb32MD57THUMBNAILImmunohistochemical expression of E-cadherin and_2010.pdf.jpgImmunohistochemical expression of E-cadherin and_2010.pdf.jpgIM Thumbnailimage/jpeg8827https://repositorio.ufrn.br/bitstream/123456789/21208/8/Immunohistochemical%20expression%20of%20E-cadherin%20and_2010.pdf.jpgc79260492e0f5549b85a5858d21e7c75MD58123456789/212082021-12-21 14:14:08.056oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-12-21T17:14:08Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
title Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
spellingShingle Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
Pereira, Karuza Maria Alves
Immunohistochemical
E-cadherin
beta-catenin
ameloblastoma
title_short Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
title_full Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
title_fullStr Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
title_full_unstemmed Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
title_sort Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
author Pereira, Karuza Maria Alves
author_facet Pereira, Karuza Maria Alves
Amaral, Bruna Aguiar do
Santos, Bruna Rafaela Martins dos
Galvão, Hebel Cavalcanti
Freitas, Roseana de Almeida
Souza, Lelia Batista de
author_role author
author2 Amaral, Bruna Aguiar do
Santos, Bruna Rafaela Martins dos
Galvão, Hebel Cavalcanti
Freitas, Roseana de Almeida
Souza, Lelia Batista de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Karuza Maria Alves
Amaral, Bruna Aguiar do
Santos, Bruna Rafaela Martins dos
Galvão, Hebel Cavalcanti
Freitas, Roseana de Almeida
Souza, Lelia Batista de
dc.subject.por.fl_str_mv Immunohistochemical
E-cadherin
beta-catenin
ameloblastoma
topic Immunohistochemical
E-cadherin
beta-catenin
ameloblastoma
description OBJECTIVE: The aim was to analyze the expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs to determine their roles in cell differentiation processes and invasiveness compared with odontogenesis. STUDY DESIGN: Twenty-one ameloblastoma cases (16 solid and 5 unicystic tumors) and 5 tooth germs were submitted to the immunohistochemical detection of E-cadherin and beta-catenin. Immunoreactivity was evaluated using descriptive and semiquantitative analysis, investigating the location and intensity of staining. The Fisher exact test was performed, and P values of <.05 were considered to indicate statistical significance. RESULTS: There was no statistically significant difference in the expression of E-cadherin and beta-catenin between solid and unicystic ameloblastomas (P = .59; P = .63; respectively). The same was found when comparing solid and unicystic ameloblastomas with the tooth germs for both E-cadherin (P = .53; P = .44; respectively) and beta-catenin (P = .12; P = .16; respectively). Nuclear staining of beta-catenin was observed in only 4 cases (3 solid and 1 unicystic tumor). CONCLUSION: The results showed no differences in the expression of E-cadherin or beta-catenin between tooth germs and solid and unicystic ameloblastomas. The expression of these molecules seems mainly to be related to the process of cell differentiation.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2016-08-22T16:35:08Z
dc.date.available.fl_str_mv 2016-08-22T16:35:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv PEREIRA, Karuza Maria Alves et al. Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, v. 109, n. 3, p. 425-431, 2010.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/21208
identifier_str_mv PEREIRA, Karuza Maria Alves et al. Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, v. 109, n. 3, p. 425-431, 2010.
url https://repositorio.ufrn.br/jspui/handle/123456789/21208
dc.language.iso.fl_str_mv eng
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