Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis B Virus subgenotype D1

Detalhes bibliográficos
Autor(a) principal: Trovão, Nídia Sequeira
Data de Publicação: 2022
Outros Autores: Thijssen, Marijn, Vrancken, Bram, Pineda-Peña, Andrea Clemencia, Mina, Thomas, Amini-Bavil-Olyaee, Samad, Lemey, Philippe, Baele, Guy, Pourkarim, Mahmoud Reza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/148975
Resumo: Funding Information: N.S.T. and P.L. were supported by the European Union Seventh Framework Programme [FP7/2007-2013] under Grant Agreement number 278433-PREDEMICS. The research leading to these results has received funding from the European Research Council under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 725422 - ReservoirDOCS). MT is a PhD fellow at the Research Foundation Flanders (FWO, Belgium, grant number 1S47118N). A.-C.P.-P. was supported by European Funds through grant 'Bio-Molecular and Epidemiological Surveillance of HIV Transmitted Drug Resistance, Hepatitis Co- Infections and Ongoing Transmission Patterns in Europe' (BEST HOPE) (project funded through HIVERA: Harmonizing Integrating Vitalizing European Research on HIV/Aids, grant 249697); by Fundação para a Cieñcia e Tecnologia for funds to GHTMUID/ Multi/04413/2013; by the Migrant HIV project (financed by FCT: PTDC/DTP-EPI/7066/2014; and by Gilead Ǵenese HIVLatePresenters. B.V. was supported by a postdoctoral grant (12U7121N) of the FWO (Fonds Wetenschappelijk Onderzoek - Vlaanderen). G.B. acknowledges support from the Interne Fondsen KU Leuven/ Internal Funds KU Leuven under grant agreement C14/18/094 and the Research Foundation - Flanders ('Fonds voor Wetenschappelijk Onderzoek - Vlaanderen', G0E1420N, G098321N). This work was supported by the Bijzonder Onderzoeksfonds KU Leuven (BOF) No. OT/14/115. This work was supported by public grants. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022 The Author(s).
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spelling Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis B Virus subgenotype D1Bayesian inferenceD1full genomeHBVMCMCphylodynamicstemporal signalRA0421 Public health. Hygiene. Preventive MedicineQR355 VirologyMicrobiologyVirologyMolecular BiologyEpidemiologyInfectious DiseasesSDG 3 - Good Health and Well-beingFunding Information: N.S.T. and P.L. were supported by the European Union Seventh Framework Programme [FP7/2007-2013] under Grant Agreement number 278433-PREDEMICS. The research leading to these results has received funding from the European Research Council under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 725422 - ReservoirDOCS). MT is a PhD fellow at the Research Foundation Flanders (FWO, Belgium, grant number 1S47118N). A.-C.P.-P. was supported by European Funds through grant 'Bio-Molecular and Epidemiological Surveillance of HIV Transmitted Drug Resistance, Hepatitis Co- Infections and Ongoing Transmission Patterns in Europe' (BEST HOPE) (project funded through HIVERA: Harmonizing Integrating Vitalizing European Research on HIV/Aids, grant 249697); by Fundação para a Cieñcia e Tecnologia for funds to GHTMUID/ Multi/04413/2013; by the Migrant HIV project (financed by FCT: PTDC/DTP-EPI/7066/2014; and by Gilead Ǵenese HIVLatePresenters. B.V. was supported by a postdoctoral grant (12U7121N) of the FWO (Fonds Wetenschappelijk Onderzoek - Vlaanderen). G.B. acknowledges support from the Interne Fondsen KU Leuven/ Internal Funds KU Leuven under grant agreement C14/18/094 and the Research Foundation - Flanders ('Fonds voor Wetenschappelijk Onderzoek - Vlaanderen', G0E1420N, G098321N). This work was supported by the Bijzonder Onderzoeksfonds KU Leuven (BOF) No. OT/14/115. This work was supported by public grants. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022 The Author(s).Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). HBV-D1 is the dominant subgenotype in the Mediterranean basin, Eastern Europe, and Asia. However, little is currently known about its evolutionary history and spatio-temporal dynamics. We use Bayesian phylodynamic inference to investigate the temporal history of HBV-D1, for which we calibrate the molecular clock using ancient sequences, and reconstruct the viral global spatial dynamics based, for the first time, on full-length publicly available HBV-D1 genomes from a wide range of sampling dates. We pinpoint the origin of HBV subgenotype D1 before the current era (BCE) in Turkey/Anatolia. The spatial reconstructions reveal global viral transmission with a high degree of mixing. By combining modern-day and ancient sequences, we ensure sufficient temporal signal in HBV-D1 data to enable Bayesian phylodynamic inference using a molecular clock for time calibration. Our results shed light on the worldwide HBV-D1 epidemics and suggest that this originally Middle Eastern virus significantly affects more distant countries, such as those in mainland Europe.TB, HIV and opportunistic diseases and pathogens (THOP)Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)RUNTrovão, Nídia SequeiraThijssen, MarijnVrancken, BramPineda-Peña, Andrea ClemenciaMina, ThomasAmini-Bavil-Olyaee, SamadLemey, PhilippeBaele, GuyPourkarim, Mahmoud Reza2023-02-09T22:22:32Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/148975eng2057-1577PURE: 50948757https://doi.org/10.1093/ve/veac028info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:30:45Zoai:run.unl.pt:10362/148975Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:34.673631Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis B Virus subgenotype D1
title Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis B Virus subgenotype D1
spellingShingle Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis B Virus subgenotype D1
Trovão, Nídia Sequeira
Bayesian inference
D1
full genome
HBV
MCMC
phylodynamics
temporal signal
RA0421 Public health. Hygiene. Preventive Medicine
QR355 Virology
Microbiology
Virology
Molecular Biology
Epidemiology
Infectious Diseases
SDG 3 - Good Health and Well-being
title_short Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis B Virus subgenotype D1
title_full Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis B Virus subgenotype D1
title_fullStr Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis B Virus subgenotype D1
title_full_unstemmed Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis B Virus subgenotype D1
title_sort Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis B Virus subgenotype D1
author Trovão, Nídia Sequeira
author_facet Trovão, Nídia Sequeira
Thijssen, Marijn
Vrancken, Bram
Pineda-Peña, Andrea Clemencia
Mina, Thomas
Amini-Bavil-Olyaee, Samad
Lemey, Philippe
Baele, Guy
Pourkarim, Mahmoud Reza
author_role author
author2 Thijssen, Marijn
Vrancken, Bram
Pineda-Peña, Andrea Clemencia
Mina, Thomas
Amini-Bavil-Olyaee, Samad
Lemey, Philippe
Baele, Guy
Pourkarim, Mahmoud Reza
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv TB, HIV and opportunistic diseases and pathogens (THOP)
Instituto de Higiene e Medicina Tropical (IHMT)
Global Health and Tropical Medicine (GHTM)
RUN
dc.contributor.author.fl_str_mv Trovão, Nídia Sequeira
Thijssen, Marijn
Vrancken, Bram
Pineda-Peña, Andrea Clemencia
Mina, Thomas
Amini-Bavil-Olyaee, Samad
Lemey, Philippe
Baele, Guy
Pourkarim, Mahmoud Reza
dc.subject.por.fl_str_mv Bayesian inference
D1
full genome
HBV
MCMC
phylodynamics
temporal signal
RA0421 Public health. Hygiene. Preventive Medicine
QR355 Virology
Microbiology
Virology
Molecular Biology
Epidemiology
Infectious Diseases
SDG 3 - Good Health and Well-being
topic Bayesian inference
D1
full genome
HBV
MCMC
phylodynamics
temporal signal
RA0421 Public health. Hygiene. Preventive Medicine
QR355 Virology
Microbiology
Virology
Molecular Biology
Epidemiology
Infectious Diseases
SDG 3 - Good Health and Well-being
description Funding Information: N.S.T. and P.L. were supported by the European Union Seventh Framework Programme [FP7/2007-2013] under Grant Agreement number 278433-PREDEMICS. The research leading to these results has received funding from the European Research Council under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 725422 - ReservoirDOCS). MT is a PhD fellow at the Research Foundation Flanders (FWO, Belgium, grant number 1S47118N). A.-C.P.-P. was supported by European Funds through grant 'Bio-Molecular and Epidemiological Surveillance of HIV Transmitted Drug Resistance, Hepatitis Co- Infections and Ongoing Transmission Patterns in Europe' (BEST HOPE) (project funded through HIVERA: Harmonizing Integrating Vitalizing European Research on HIV/Aids, grant 249697); by Fundação para a Cieñcia e Tecnologia for funds to GHTMUID/ Multi/04413/2013; by the Migrant HIV project (financed by FCT: PTDC/DTP-EPI/7066/2014; and by Gilead Ǵenese HIVLatePresenters. B.V. was supported by a postdoctoral grant (12U7121N) of the FWO (Fonds Wetenschappelijk Onderzoek - Vlaanderen). G.B. acknowledges support from the Interne Fondsen KU Leuven/ Internal Funds KU Leuven under grant agreement C14/18/094 and the Research Foundation - Flanders ('Fonds voor Wetenschappelijk Onderzoek - Vlaanderen', G0E1420N, G098321N). This work was supported by the Bijzonder Onderzoeksfonds KU Leuven (BOF) No. OT/14/115. This work was supported by public grants. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022 The Author(s).
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-02-09T22:22:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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PURE: 50948757
https://doi.org/10.1093/ve/veac028
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