Early Evidence of Circulating SARS-CoV-2 in Unvaccinated and Vaccinated Measles Patients, September 2019–February 2020
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/148415 |
Resumo: | Funding Information: This study was funded as a donation from the Ministry of Health, Angola. Publisher Copyright: © 2022 Paixao et al. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Early Evidence of Circulating SARS-CoV-2 in Unvaccinated and Vaccinated Measles Patients, September 2019–February 2020AntibodiesCOVID-19Humoral responseInfectionPandemicQR180 ImmunologyQR355 VirologyRA0421 Public health. Hygiene. Preventive MedicinePharmacologyInfectious DiseasesPharmacology (medical)ImmunologyVirologySDG 3 - Good Health and Well-beingFunding Information: This study was funded as a donation from the Ministry of Health, Angola. Publisher Copyright: © 2022 Paixao et al.Background: The global emergence of coronavirus disease 2019 (COVID-19) has challenged healthcare and rapidly spread over the globe. Early detection of new infections is crucial in the control of emerging diseases. Evidence of early recorded COVID-19 cases outside China has been documented in various countries. In this study, we aimed to identify the time of SARS-CoV-2 infection circulation by retrospectively analyzing sera of measles patients, weeks before the reported first COVID-19 cases in Angola. Materials and Methods: We examined the humoral response against SARS-CoV-2 by using an enzyme-linked immunosorbent assay (ELISA)-based assay on a combined two-step sandwich enzyme immunoassay method. In total, we received 568 study patients with blood specimens collected from 23 September 2019 to 28 February 2020, 442 sera samples that met the criteria of the study were withdrawn and selected from the overall 568 received samples. In this study, we considered seropositives, patients who tested positive for SARS-CoV-2 immunoglobulin G (IgG) and M (IgM) antibodies with the index value >1. Results: Of the 442 sera samples that met the criteria of the study, 204 were measles seropositive. Forty out of 204 were confirmed reactive to SARS-CoV-2 viral proteins using IgG and IgM more than 2 weeks before the first reported case in Angola. The humoral response analysis showed significant differences (p = 0.01) between the IgG and IgM indexes in the unvaccinated measles patients. Similarly, a significant difference (p = 0.001) was seen between the IgG and IgM indexes in the vaccinated measles patients. Conclusion: Here, using the humoral response analysis, we report the identification of early circulation SARS-CoV-2 infection weeks before the first recognized cases in the Republic of Angola.Instituto de Higiene e Medicina Tropical (IHMT)RUNPaixao, JoanaGalangue, MariaGaston, CelestinaCarralero, RaísaLino, CelestinaJúlio, GraciethDavid, ZingaFrancisco, MoisesSebastião, Cruz S.Sacomboio, Euclides N.M.Morais, JoanaFrancisco, Ngiambudulu M.2023-01-30T22:18:28Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://hdl.handle.net/10362/148415eng1178-6973PURE: 50960146https://doi.org/10.2147/IDR.S344437info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:08:40Zoai:run.unl.pt:10362/148415Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:08:40Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Early Evidence of Circulating SARS-CoV-2 in Unvaccinated and Vaccinated Measles Patients, September 2019–February 2020 |
| title |
Early Evidence of Circulating SARS-CoV-2 in Unvaccinated and Vaccinated Measles Patients, September 2019–February 2020 |
| spellingShingle |
Early Evidence of Circulating SARS-CoV-2 in Unvaccinated and Vaccinated Measles Patients, September 2019–February 2020 Paixao, Joana Antibodies COVID-19 Humoral response Infection Pandemic QR180 Immunology QR355 Virology RA0421 Public health. Hygiene. Preventive Medicine Pharmacology Infectious Diseases Pharmacology (medical) Immunology Virology SDG 3 - Good Health and Well-being |
| title_short |
Early Evidence of Circulating SARS-CoV-2 in Unvaccinated and Vaccinated Measles Patients, September 2019–February 2020 |
| title_full |
Early Evidence of Circulating SARS-CoV-2 in Unvaccinated and Vaccinated Measles Patients, September 2019–February 2020 |
| title_fullStr |
Early Evidence of Circulating SARS-CoV-2 in Unvaccinated and Vaccinated Measles Patients, September 2019–February 2020 |
| title_full_unstemmed |
Early Evidence of Circulating SARS-CoV-2 in Unvaccinated and Vaccinated Measles Patients, September 2019–February 2020 |
| title_sort |
Early Evidence of Circulating SARS-CoV-2 in Unvaccinated and Vaccinated Measles Patients, September 2019–February 2020 |
| author |
Paixao, Joana |
| author_facet |
Paixao, Joana Galangue, Maria Gaston, Celestina Carralero, Raísa Lino, Celestina Júlio, Gracieth David, Zinga Francisco, Moises Sebastião, Cruz S. Sacomboio, Euclides N.M. Morais, Joana Francisco, Ngiambudulu M. |
| author_role |
author |
| author2 |
Galangue, Maria Gaston, Celestina Carralero, Raísa Lino, Celestina Júlio, Gracieth David, Zinga Francisco, Moises Sebastião, Cruz S. Sacomboio, Euclides N.M. Morais, Joana Francisco, Ngiambudulu M. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) RUN |
| dc.contributor.author.fl_str_mv |
Paixao, Joana Galangue, Maria Gaston, Celestina Carralero, Raísa Lino, Celestina Júlio, Gracieth David, Zinga Francisco, Moises Sebastião, Cruz S. Sacomboio, Euclides N.M. Morais, Joana Francisco, Ngiambudulu M. |
| dc.subject.por.fl_str_mv |
Antibodies COVID-19 Humoral response Infection Pandemic QR180 Immunology QR355 Virology RA0421 Public health. Hygiene. Preventive Medicine Pharmacology Infectious Diseases Pharmacology (medical) Immunology Virology SDG 3 - Good Health and Well-being |
| topic |
Antibodies COVID-19 Humoral response Infection Pandemic QR180 Immunology QR355 Virology RA0421 Public health. Hygiene. Preventive Medicine Pharmacology Infectious Diseases Pharmacology (medical) Immunology Virology SDG 3 - Good Health and Well-being |
| description |
Funding Information: This study was funded as a donation from the Ministry of Health, Angola. Publisher Copyright: © 2022 Paixao et al. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-01-01T00:00:00Z 2023-01-30T22:18:28Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/148415 |
| url |
http://hdl.handle.net/10362/148415 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1178-6973 PURE: 50960146 https://doi.org/10.2147/IDR.S344437 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
12 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817545913375129600 |