A catalogue of the prophages of the genus Helicobacter

Detalhes bibliográficos
Autor(a) principal: Proença, Marta Sousa
Data de Publicação: 2023
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/62557
Resumo: Tese de mestrado, Bioinformática e Biologia Computacional , 2023, Universidade de Lisboa, Faculdade de Ciências
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spelling A catalogue of the prophages of the genus HelicobacterCo-evoluçãofilogeniaHelicobacterprofagoTeses de mestrado - 2023Departamento de InformáticaTese de mestrado, Bioinformática e Biologia Computacional , 2023, Universidade de Lisboa, Faculdade de CiênciasThe genus Helicobacter comprises species that colonize the gastric mucosa (gastric Helicobacter, like Helicobacter pylori) and the liver/intestinal tracts (enterohepatic Helicobacter) of distinct classes of the subphylum Vertebrata. Complete H. pylori prophages showed that prophage genes tend to belong to the host’s phylogeographic group, reinforcing co-evolution. However, this scenario between prophages and host bacteria within the genus Helicobacter remains undetermined. This thesis’ main goal is to analyze and identify prophage elementsin Helicobacter species and comprehend the co-evolutionary scenario between prophages and their hosts. A collection of 343 genomes from non-pylori Helicobacter was analyzed. A total of 119 complete prophages were found and analyzed, scoping their genome characteristics and families. There were 457 orthologous genes found in all complete prophages, with higher number of orthologous genes observed in enterohepatic prophages compared to gastric ones, mirroring the same trend in their respective bacterial hosts. In the phylogenetic tree of all complete prophages, Hpametensis1288_1, Hjaachi09_6949, and H. canis prophages didn’t follow the cluster division segregating gastric and enterohepatic species, typically found among Helicobacter species. This difference was also evident by shared genes network analysis and gene synteny. The phylogenetic congruence between the trees of bacteria and prophages evidenced a general dependence of the phage phylogeny on the host’s phylogeny, even with some individual pairs not contributing to these results. These divergence results were found within gastric or enterohepatic groups, depicting a distinct evolutionary history at a narrower level. Overall, the Helicobacter prophages seem to have a co-evolution with their hosts, with high synteny, and the gastric prophages appear to have a higher diversity, although some exceptions arise. This study introduces a novel set of prophage sequences associated with non-pylori Helicobacter species, serving as valuable foundation for exploring prophages within the Helicobacter genus, and offering comprehensive insights into their presence and co-evolutionary history.Vale, Ana Filipa Ferreira do, 1973-Carvalho, Margarida Henriques da Gama, 1972-Repositório da Universidade de LisboaProença, Marta Sousa202320232026-10-26T00:00:00Z2023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10451/62557TID:203519949enginfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:28:01Zoai:repositorio.ul.pt:10451/62557Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:28:01Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A catalogue of the prophages of the genus Helicobacter
title A catalogue of the prophages of the genus Helicobacter
spellingShingle A catalogue of the prophages of the genus Helicobacter
Proença, Marta Sousa
Co-evolução
filogenia
Helicobacter
profago
Teses de mestrado - 2023
Departamento de Informática
title_short A catalogue of the prophages of the genus Helicobacter
title_full A catalogue of the prophages of the genus Helicobacter
title_fullStr A catalogue of the prophages of the genus Helicobacter
title_full_unstemmed A catalogue of the prophages of the genus Helicobacter
title_sort A catalogue of the prophages of the genus Helicobacter
author Proença, Marta Sousa
author_facet Proença, Marta Sousa
author_role author
dc.contributor.none.fl_str_mv Vale, Ana Filipa Ferreira do, 1973-
Carvalho, Margarida Henriques da Gama, 1972-
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Proença, Marta Sousa
dc.subject.por.fl_str_mv Co-evolução
filogenia
Helicobacter
profago
Teses de mestrado - 2023
Departamento de Informática
topic Co-evolução
filogenia
Helicobacter
profago
Teses de mestrado - 2023
Departamento de Informática
description Tese de mestrado, Bioinformática e Biologia Computacional , 2023, Universidade de Lisboa, Faculdade de Ciências
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023-01-01T00:00:00Z
2026-10-26T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/62557
TID:203519949
url http://hdl.handle.net/10451/62557
identifier_str_mv TID:203519949
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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