Implicit contextual learning in prodromal and early stage Huntington's disease patients
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/92840 https://doi.org/10.1017/S1355617712000288 |
Resumo: | Huntington's disease (HD) is a genetic neurodegenerative disorder affecting the basal ganglia. These subcortical structures are particularly important for motor functions, response selection and implicit learning. In the current study, we have assessed prodromal and symptomatic HD participants with an implicit contextual learning task that is not based on motor learning, but on a purely visual implicit learning mechanism. We used an implicit contextual learning task in which subjects need to locate a target among several distractors. In half of the trials, the positions of the distractors and target stimuli were repeated. By memorizing this contextual information, attention can be guided faster to the target stimulus. Nine symptomatic HD participants, 16 prodromal HD participants and 22 control subjects were included. We found that the responses of the control subjects were faster for the repeated trials than for the new trials, indicating that their visual search was facilitated when repeated contextual information was present. In contrast, no difference in response times between the repeated and new trials was found for the symptomatic and prodromal HD participants. The results of the current study indicate that both prodromal and symptomatic HD participants are impaired on an implicit contextual learning task. |
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Implicit contextual learning in prodromal and early stage Huntington's disease patientsAdultAttentionCuesDisease ProgressionFemaleHumansHuntington DiseaseMaleMemoryMiddle AgedNeuropsychological TestsReaction TimeRecognition, PsychologyLearningHuntington's disease (HD) is a genetic neurodegenerative disorder affecting the basal ganglia. These subcortical structures are particularly important for motor functions, response selection and implicit learning. In the current study, we have assessed prodromal and symptomatic HD participants with an implicit contextual learning task that is not based on motor learning, but on a purely visual implicit learning mechanism. We used an implicit contextual learning task in which subjects need to locate a target among several distractors. In half of the trials, the positions of the distractors and target stimuli were repeated. By memorizing this contextual information, attention can be guided faster to the target stimulus. Nine symptomatic HD participants, 16 prodromal HD participants and 22 control subjects were included. We found that the responses of the control subjects were faster for the repeated trials than for the new trials, indicating that their visual search was facilitated when repeated contextual information was present. In contrast, no difference in response times between the repeated and new trials was found for the symptomatic and prodromal HD participants. The results of the current study indicate that both prodromal and symptomatic HD participants are impaired on an implicit contextual learning task.Cambridge University Press2012-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/92840http://hdl.handle.net/10316/92840https://doi.org/10.1017/S1355617712000288eng1355-61771469-7661https://www.cambridge.org/core/journals/journal-of-the-international-neuropsychological-society/article/implicit-contextual-learning-in-prodromal-and-early-stage-huntingtons-disease-patients/0B1C4B959F0E8B22C118FD5F39C556C6#articlevan Asselen, MariekeAlmeida, InêsJúlio, FilipaJanuário, CristinaCampos, Elzbieta BobrowiczSimões, MárioCastelo-Branco, Miguelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T06:35:08Zoai:estudogeral.uc.pt:10316/92840Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:11:53.195144Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Implicit contextual learning in prodromal and early stage Huntington's disease patients |
title |
Implicit contextual learning in prodromal and early stage Huntington's disease patients |
spellingShingle |
Implicit contextual learning in prodromal and early stage Huntington's disease patients van Asselen, Marieke Adult Attention Cues Disease Progression Female Humans Huntington Disease Male Memory Middle Aged Neuropsychological Tests Reaction Time Recognition, Psychology Learning |
title_short |
Implicit contextual learning in prodromal and early stage Huntington's disease patients |
title_full |
Implicit contextual learning in prodromal and early stage Huntington's disease patients |
title_fullStr |
Implicit contextual learning in prodromal and early stage Huntington's disease patients |
title_full_unstemmed |
Implicit contextual learning in prodromal and early stage Huntington's disease patients |
title_sort |
Implicit contextual learning in prodromal and early stage Huntington's disease patients |
author |
van Asselen, Marieke |
author_facet |
van Asselen, Marieke Almeida, Inês Júlio, Filipa Januário, Cristina Campos, Elzbieta Bobrowicz Simões, Mário Castelo-Branco, Miguel |
author_role |
author |
author2 |
Almeida, Inês Júlio, Filipa Januário, Cristina Campos, Elzbieta Bobrowicz Simões, Mário Castelo-Branco, Miguel |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
van Asselen, Marieke Almeida, Inês Júlio, Filipa Januário, Cristina Campos, Elzbieta Bobrowicz Simões, Mário Castelo-Branco, Miguel |
dc.subject.por.fl_str_mv |
Adult Attention Cues Disease Progression Female Humans Huntington Disease Male Memory Middle Aged Neuropsychological Tests Reaction Time Recognition, Psychology Learning |
topic |
Adult Attention Cues Disease Progression Female Humans Huntington Disease Male Memory Middle Aged Neuropsychological Tests Reaction Time Recognition, Psychology Learning |
description |
Huntington's disease (HD) is a genetic neurodegenerative disorder affecting the basal ganglia. These subcortical structures are particularly important for motor functions, response selection and implicit learning. In the current study, we have assessed prodromal and symptomatic HD participants with an implicit contextual learning task that is not based on motor learning, but on a purely visual implicit learning mechanism. We used an implicit contextual learning task in which subjects need to locate a target among several distractors. In half of the trials, the positions of the distractors and target stimuli were repeated. By memorizing this contextual information, attention can be guided faster to the target stimulus. Nine symptomatic HD participants, 16 prodromal HD participants and 22 control subjects were included. We found that the responses of the control subjects were faster for the repeated trials than for the new trials, indicating that their visual search was facilitated when repeated contextual information was present. In contrast, no difference in response times between the repeated and new trials was found for the symptomatic and prodromal HD participants. The results of the current study indicate that both prodromal and symptomatic HD participants are impaired on an implicit contextual learning task. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-07 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/92840 http://hdl.handle.net/10316/92840 https://doi.org/10.1017/S1355617712000288 |
url |
http://hdl.handle.net/10316/92840 https://doi.org/10.1017/S1355617712000288 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1355-6177 1469-7661 https://www.cambridge.org/core/journals/journal-of-the-international-neuropsychological-society/article/implicit-contextual-learning-in-prodromal-and-early-stage-huntingtons-disease-patients/0B1C4B959F0E8B22C118FD5F39C556C6#article |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Cambridge University Press |
publisher.none.fl_str_mv |
Cambridge University Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134015208292352 |