Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/13858 |
Resumo: | This study describes a template-mediated self-assembly synthesis, full characterization, and structural features of two new silver-based bioactive coordination polymers (CPs) and their immobilization into acrylated epoxidized soybean oil (ESOA) biopolymer films for antimicrobial applications. The 3D silver(I) CPs [Ag-4(mu(8)-H(2)pma)(2)](n)center dot 4nH(2)O (1) and [Ag-5(mu(6)-H(0.5)tma)(2)(H2O)(4)] (n)center dot 2nH(2)O (2) were generated from AgNO3 and pyromellitic (H(4)pma) or trimesic (H(3)tma) acid, also using N,N'-dimethylethanolamine (Hdmea) as a template. Both 1 and 2 feature the intricate 3D layer-pillared structures driven by distinct polycarboxylate blocks. Topological analysis revealed binodal nets with the flu and tcj/hc topology in 1 and 2, respectively. These CPs were used for fabricating new hybrid materials, namely, by doping the [ESOA](n) biopolymer films with very low amounts of 1 and 2 (0.05, 0.1, and 0.5%). Their antimicrobial activity and ability to impair bacterial biofilm formation were investigated in detail against both Gram-positive (Staphylococcus epidermidis and Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. Both silver(I) CPs and derived biopolymer films showed activity against all the tested bacteria in a concentration-dependent manner. Compound 1 exhibited a more pronounced activity, especially in preventing biofilm growth, with mean bacterial load reductions ranging from 3.7 to 4.3 log against the four bacteria (99.99% bacterial eradication). The present work thus opens up antibiofilm applications of CP-doped biopolymers, providing new perspectives and very promising results for the design of functional biomaterials. |
id |
RCAP_9c88599811e156ab89ff1423d9436830 |
---|---|
oai_identifier_str |
oai:repositorio.ipl.pt:10400.21/13858 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applicationsMetal-organic frameworksSilverCrystal structuresHybrid materialsAntibacterial activityBiopolymersBiofilmsThis study describes a template-mediated self-assembly synthesis, full characterization, and structural features of two new silver-based bioactive coordination polymers (CPs) and their immobilization into acrylated epoxidized soybean oil (ESOA) biopolymer films for antimicrobial applications. The 3D silver(I) CPs [Ag-4(mu(8)-H(2)pma)(2)](n)center dot 4nH(2)O (1) and [Ag-5(mu(6)-H(0.5)tma)(2)(H2O)(4)] (n)center dot 2nH(2)O (2) were generated from AgNO3 and pyromellitic (H(4)pma) or trimesic (H(3)tma) acid, also using N,N'-dimethylethanolamine (Hdmea) as a template. Both 1 and 2 feature the intricate 3D layer-pillared structures driven by distinct polycarboxylate blocks. Topological analysis revealed binodal nets with the flu and tcj/hc topology in 1 and 2, respectively. These CPs were used for fabricating new hybrid materials, namely, by doping the [ESOA](n) biopolymer films with very low amounts of 1 and 2 (0.05, 0.1, and 0.5%). Their antimicrobial activity and ability to impair bacterial biofilm formation were investigated in detail against both Gram-positive (Staphylococcus epidermidis and Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. Both silver(I) CPs and derived biopolymer films showed activity against all the tested bacteria in a concentration-dependent manner. Compound 1 exhibited a more pronounced activity, especially in preventing biofilm growth, with mean bacterial load reductions ranging from 3.7 to 4.3 log against the four bacteria (99.99% bacterial eradication). The present work thus opens up antibiofilm applications of CP-doped biopolymers, providing new perspectives and very promising results for the design of functional biomaterials.American Chemical SocietyRCIPLFernandes, TiagoCosta, Inês F. M.Jorge, PaulaSousa, Ana CatarinaAndré, VâniaCerca, N.Kirillov, Alexander M.2021-10-11T12:53:26Z2021-03-242021-03-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/13858engFERNANDES, Tiago A.; [et al] – Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications. ACS Applied Materials and Interfaces. ISSN 1944-8244. Vol. 13, N.º 11 (2021), pp. 12836-128441944-824410.1021/acsami.0c194461944-8252metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:09:16Zoai:repositorio.ipl.pt:10400.21/13858Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:21:44.135654Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications |
title |
Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications |
spellingShingle |
Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications Fernandes, Tiago Metal-organic frameworks Silver Crystal structures Hybrid materials Antibacterial activity Biopolymers Biofilms |
title_short |
Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications |
title_full |
Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications |
title_fullStr |
Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications |
title_full_unstemmed |
Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications |
title_sort |
Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications |
author |
Fernandes, Tiago |
author_facet |
Fernandes, Tiago Costa, Inês F. M. Jorge, Paula Sousa, Ana Catarina André, Vânia Cerca, N. Kirillov, Alexander M. |
author_role |
author |
author2 |
Costa, Inês F. M. Jorge, Paula Sousa, Ana Catarina André, Vânia Cerca, N. Kirillov, Alexander M. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Fernandes, Tiago Costa, Inês F. M. Jorge, Paula Sousa, Ana Catarina André, Vânia Cerca, N. Kirillov, Alexander M. |
dc.subject.por.fl_str_mv |
Metal-organic frameworks Silver Crystal structures Hybrid materials Antibacterial activity Biopolymers Biofilms |
topic |
Metal-organic frameworks Silver Crystal structures Hybrid materials Antibacterial activity Biopolymers Biofilms |
description |
This study describes a template-mediated self-assembly synthesis, full characterization, and structural features of two new silver-based bioactive coordination polymers (CPs) and their immobilization into acrylated epoxidized soybean oil (ESOA) biopolymer films for antimicrobial applications. The 3D silver(I) CPs [Ag-4(mu(8)-H(2)pma)(2)](n)center dot 4nH(2)O (1) and [Ag-5(mu(6)-H(0.5)tma)(2)(H2O)(4)] (n)center dot 2nH(2)O (2) were generated from AgNO3 and pyromellitic (H(4)pma) or trimesic (H(3)tma) acid, also using N,N'-dimethylethanolamine (Hdmea) as a template. Both 1 and 2 feature the intricate 3D layer-pillared structures driven by distinct polycarboxylate blocks. Topological analysis revealed binodal nets with the flu and tcj/hc topology in 1 and 2, respectively. These CPs were used for fabricating new hybrid materials, namely, by doping the [ESOA](n) biopolymer films with very low amounts of 1 and 2 (0.05, 0.1, and 0.5%). Their antimicrobial activity and ability to impair bacterial biofilm formation were investigated in detail against both Gram-positive (Staphylococcus epidermidis and Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. Both silver(I) CPs and derived biopolymer films showed activity against all the tested bacteria in a concentration-dependent manner. Compound 1 exhibited a more pronounced activity, especially in preventing biofilm growth, with mean bacterial load reductions ranging from 3.7 to 4.3 log against the four bacteria (99.99% bacterial eradication). The present work thus opens up antibiofilm applications of CP-doped biopolymers, providing new perspectives and very promising results for the design of functional biomaterials. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-11T12:53:26Z 2021-03-24 2021-03-24T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/13858 |
url |
http://hdl.handle.net/10400.21/13858 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
FERNANDES, Tiago A.; [et al] – Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications. ACS Applied Materials and Interfaces. ISSN 1944-8244. Vol. 13, N.º 11 (2021), pp. 12836-12844 1944-8244 10.1021/acsami.0c19446 1944-8252 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799133488968892416 |