Development of natural polymeric microcapsules for antimicrobial drug delivery: triclosan loaded chitosan and alginate-based microcapsules

• Autor(a) principal: Alves de Lima, Caroline Santos
• Data de Publicação: 2020
• Outros Autores: Costa Varca, Gustavo Henrique, Costa, Sirlene Maria da, Ferraz, Humberto Gomes, Silva Santos, Ana Carolina da [UNESP], Lopes, Patricia Santos, Costa, Silgia Aparecida da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1080/03639045.2020.1809445; http://hdl.handle.net/11449/197204
• topic: Biopolymers; microparticles; antibacterial; chitosan; sodium alginate; triclosan

The goal of this work was the development of natural polymeric microcapsules for antimicrobial drug delivery - triclosan loaded alginate and chitosan-based microcapsules for potential coating applications in substrates such as textiles or plastics. Microcapsules containing 2.5% (w/w) or 3% (w/w) triclosan in both core and matrix were synthesized and evaluated by Fourier-transform infrared spectroscopy, scanning electron microscopy, confocal microscopy, differential scanning calorimetry, thermogravimetry, and antimicrobial activity. The microcapsules produced featured spherical and mostly irregularly-shaped surfaces composed by an alginate core in a chitosan outer matrix, as revealed by confocal microscopy, and antimicrobial activity againstS. aureusandE. coliwith inhibition halos up to 60 mm and 25 mm respectively, granted by a triclosan loading of 61.66%. The thermal analysis suggested that the polymers protected the active substance from temperature-induced degradation. In conclusion, these microcapsules may be applied toward antimicrobial functionalization of plastics, textiles and other materials.