Vascular Oxidative Stress: Impact and Therapeutic Approaches

Detalhes bibliográficos
Autor(a) principal: Sena, Cristina M.
Data de Publicação: 2018
Outros Autores: Leandro, Adriana, Azul, Lara, Seiça, Raquel, Perry, George
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
DOI: 10.3389/fphys.2018.01668
Texto Completo: http://hdl.handle.net/10316/107636
https://doi.org/10.3389/fphys.2018.01668
Resumo: Oxidative stress has been defined as an imbalance between oxidants and antioxidants and more recently as a disruption of redox signaling and control. It is generally accepted that oxidative stress can lead to cell and tissue injury having a fundamental role in vascular dysfunction. Physiologically, reactive oxygen species (ROS) control vascular function by modulating various redox-sensitive signaling pathways. In vascular disorders, oxidative stress instigates endothelial dysfunction and inflammation, affecting several cells in the vascular wall. Vascular ROS are derived from multiple sources herein discussed, which are prime targets for therapeutic development. This review focuses on oxidative stress in vascular physiopathology and highlights different strategies to inhibit ROS production.
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spelling Vascular Oxidative Stress: Impact and Therapeutic Approachesoxidative stressvasculaturereactive oxygen speciestherapiesantioxidantsOxidative stress has been defined as an imbalance between oxidants and antioxidants and more recently as a disruption of redox signaling and control. It is generally accepted that oxidative stress can lead to cell and tissue injury having a fundamental role in vascular dysfunction. Physiologically, reactive oxygen species (ROS) control vascular function by modulating various redox-sensitive signaling pathways. In vascular disorders, oxidative stress instigates endothelial dysfunction and inflammation, affecting several cells in the vascular wall. Vascular ROS are derived from multiple sources herein discussed, which are prime targets for therapeutic development. This review focuses on oxidative stress in vascular physiopathology and highlights different strategies to inhibit ROS production.Frontiers Media S.A.2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107636http://hdl.handle.net/10316/107636https://doi.org/10.3389/fphys.2018.01668eng1664-042X30564132Sena, Cristina M.Leandro, AdrianaAzul, LaraSeiça, RaquelPerry, Georgeinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-25T10:44:39Zoai:estudogeral.uc.pt:10316/107636Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:58.064071Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Vascular Oxidative Stress: Impact and Therapeutic Approaches
title Vascular Oxidative Stress: Impact and Therapeutic Approaches
spellingShingle Vascular Oxidative Stress: Impact and Therapeutic Approaches
Vascular Oxidative Stress: Impact and Therapeutic Approaches
Sena, Cristina M.
oxidative stress
vasculature
reactive oxygen species
therapies
antioxidants
Sena, Cristina M.
oxidative stress
vasculature
reactive oxygen species
therapies
antioxidants
title_short Vascular Oxidative Stress: Impact and Therapeutic Approaches
title_full Vascular Oxidative Stress: Impact and Therapeutic Approaches
title_fullStr Vascular Oxidative Stress: Impact and Therapeutic Approaches
Vascular Oxidative Stress: Impact and Therapeutic Approaches
title_full_unstemmed Vascular Oxidative Stress: Impact and Therapeutic Approaches
Vascular Oxidative Stress: Impact and Therapeutic Approaches
title_sort Vascular Oxidative Stress: Impact and Therapeutic Approaches
author Sena, Cristina M.
author_facet Sena, Cristina M.
Sena, Cristina M.
Leandro, Adriana
Azul, Lara
Seiça, Raquel
Perry, George
Leandro, Adriana
Azul, Lara
Seiça, Raquel
Perry, George
author_role author
author2 Leandro, Adriana
Azul, Lara
Seiça, Raquel
Perry, George
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Sena, Cristina M.
Leandro, Adriana
Azul, Lara
Seiça, Raquel
Perry, George
dc.subject.por.fl_str_mv oxidative stress
vasculature
reactive oxygen species
therapies
antioxidants
topic oxidative stress
vasculature
reactive oxygen species
therapies
antioxidants
description Oxidative stress has been defined as an imbalance between oxidants and antioxidants and more recently as a disruption of redox signaling and control. It is generally accepted that oxidative stress can lead to cell and tissue injury having a fundamental role in vascular dysfunction. Physiologically, reactive oxygen species (ROS) control vascular function by modulating various redox-sensitive signaling pathways. In vascular disorders, oxidative stress instigates endothelial dysfunction and inflammation, affecting several cells in the vascular wall. Vascular ROS are derived from multiple sources herein discussed, which are prime targets for therapeutic development. This review focuses on oxidative stress in vascular physiopathology and highlights different strategies to inhibit ROS production.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/107636
http://hdl.handle.net/10316/107636
https://doi.org/10.3389/fphys.2018.01668
url http://hdl.handle.net/10316/107636
https://doi.org/10.3389/fphys.2018.01668
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1664-042X
30564132
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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dc.identifier.doi.none.fl_str_mv 10.3389/fphys.2018.01668

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