Chitosan beads as templates for layer-by-layer assembly and their application in the sustained release of bioactive agents

Detalhes bibliográficos
Autor(a) principal: Grech, Jessica M. R.
Data de Publicação: 2008
Outros Autores: Mano, J. F., Reis, R. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/20265
Resumo: Uncoated chitosan beads and chitosan beads coated with hyaluronic acid/chitosan (HA/Ch) multilayers, were used to investigate the controlled release of gentamicin sulphate (GS). Greater encapsulation efficiency was observed for the layer—by-layer multilayer coated beads. The in vitro drug release was in a slower sustained manner compared with noncoated chitosan beads. The differences in in vitro drug release results may be explained by the barrier effect of the coating that impedes diffusion of GS and supporting complementary water uptake. These findings indicated that a slower sustained release of gentamicin can be obtained using multilayer coatings of HA/Ch on chitosan beads and that this process could be used as a drug delivery system. In addition, agglomerates of these bead could provide a porous support in tissue engineering applications.
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spelling Chitosan beads as templates for layer-by-layer assembly and their application in the sustained release of bioactive agentsLayer-by-layerChitosan beadsBead coatingsDrug releaseGentamicin deliveryControlled deliveryTissue engineeringScaffoldUncoated chitosan beads and chitosan beads coated with hyaluronic acid/chitosan (HA/Ch) multilayers, were used to investigate the controlled release of gentamicin sulphate (GS). Greater encapsulation efficiency was observed for the layer—by-layer multilayer coated beads. The in vitro drug release was in a slower sustained manner compared with noncoated chitosan beads. The differences in in vitro drug release results may be explained by the barrier effect of the coating that impedes diffusion of GS and supporting complementary water uptake. These findings indicated that a slower sustained release of gentamicin can be obtained using multilayer coatings of HA/Ch on chitosan beads and that this process could be used as a drug delivery system. In addition, agglomerates of these bead could provide a porous support in tissue engineering applications.SAGEUniversidade do MinhoGrech, Jessica M. R.Mano, J. F.Reis, R. L.20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/20265eng0883-911510.1177/0883911508093389http://jbc.sagepub.com/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:48:12Zoai:repositorium.sdum.uminho.pt:1822/20265Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:46:23.601428Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chitosan beads as templates for layer-by-layer assembly and their application in the sustained release of bioactive agents
title Chitosan beads as templates for layer-by-layer assembly and their application in the sustained release of bioactive agents
spellingShingle Chitosan beads as templates for layer-by-layer assembly and their application in the sustained release of bioactive agents
Grech, Jessica M. R.
Layer-by-layer
Chitosan beads
Bead coatings
Drug release
Gentamicin delivery
Controlled delivery
Tissue engineering
Scaffold
title_short Chitosan beads as templates for layer-by-layer assembly and their application in the sustained release of bioactive agents
title_full Chitosan beads as templates for layer-by-layer assembly and their application in the sustained release of bioactive agents
title_fullStr Chitosan beads as templates for layer-by-layer assembly and their application in the sustained release of bioactive agents
title_full_unstemmed Chitosan beads as templates for layer-by-layer assembly and their application in the sustained release of bioactive agents
title_sort Chitosan beads as templates for layer-by-layer assembly and their application in the sustained release of bioactive agents
author Grech, Jessica M. R.
author_facet Grech, Jessica M. R.
Mano, J. F.
Reis, R. L.
author_role author
author2 Mano, J. F.
Reis, R. L.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Grech, Jessica M. R.
Mano, J. F.
Reis, R. L.
dc.subject.por.fl_str_mv Layer-by-layer
Chitosan beads
Bead coatings
Drug release
Gentamicin delivery
Controlled delivery
Tissue engineering
Scaffold
topic Layer-by-layer
Chitosan beads
Bead coatings
Drug release
Gentamicin delivery
Controlled delivery
Tissue engineering
Scaffold
description Uncoated chitosan beads and chitosan beads coated with hyaluronic acid/chitosan (HA/Ch) multilayers, were used to investigate the controlled release of gentamicin sulphate (GS). Greater encapsulation efficiency was observed for the layer—by-layer multilayer coated beads. The in vitro drug release was in a slower sustained manner compared with noncoated chitosan beads. The differences in in vitro drug release results may be explained by the barrier effect of the coating that impedes diffusion of GS and supporting complementary water uptake. These findings indicated that a slower sustained release of gentamicin can be obtained using multilayer coatings of HA/Ch on chitosan beads and that this process could be used as a drug delivery system. In addition, agglomerates of these bead could provide a porous support in tissue engineering applications.
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/20265
url http://hdl.handle.net/1822/20265
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0883-9115
10.1177/0883911508093389
http://jbc.sagepub.com/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SAGE
publisher.none.fl_str_mv SAGE
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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