Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors

Detalhes bibliográficos
Autor(a) principal: Leitão, Ana Lúcia
Data de Publicação: 2021
Outros Autores: Enguita, Francisco J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/129523
Resumo: PTDC-MED-GEN-29389-2017
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spelling Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighborsBiodegradationDepolymerizing esteraseEsterasePETasePlastic polymerPolyesterCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 12 - Responsible Consumption and ProductionSDG 14 - Life Below WaterPTDC-MED-GEN-29389-2017Esters are organic compounds widely represented in cellular structures and metabolism, originated by the condensation of organic acids and alcohols. Esterification reactions are also used by chemical industries for the production of synthetic plastic polymers. Polyester plastics are an increasing source of environmental pollution due to their intrinsic stability and limited recycling efforts. Bioremediation of polyesters based on the use of specific microbial enzymes is an interesting alternative to the current methods for the valorization of used plastics. Microbial esterases are prom-ising catalysts for the biodegradation of polyesters that can be engineered to improve their biochemical properties. In this work, we analyzed the structure-activity relationships in microbial esterases, with special focus on the recently described plastic-degrading enzymes isolated from marine microorganisms and their structural homologs. Our analysis, based on structure-alignment, molecular docking, coevolution of amino acids and surface electrostatics determined the specific characteristics of some polyester hydrolases that could be related with their efficiency in the degradation of aromatic polyesters, such as phthalates.MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de RecursosRUNLeitão, Ana LúciaEnguita, Francisco J.2021-12-20T23:16:46Z2021-03-012021-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://hdl.handle.net/10362/129523eng1661-6596PURE: 28766656https://doi.org/10.3390/ijms22052332info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:08:36Zoai:run.unl.pt:10362/129523Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:46:33.155019Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
title Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
spellingShingle Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
Leitão, Ana Lúcia
Biodegradation
Depolymerizing esterase
Esterase
PETase
Plastic polymer
Polyester
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 12 - Responsible Consumption and Production
SDG 14 - Life Below Water
title_short Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
title_full Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
title_fullStr Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
title_full_unstemmed Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
title_sort Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
author Leitão, Ana Lúcia
author_facet Leitão, Ana Lúcia
Enguita, Francisco J.
author_role author
author2 Enguita, Francisco J.
author2_role author
dc.contributor.none.fl_str_mv MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de Recursos
RUN
dc.contributor.author.fl_str_mv Leitão, Ana Lúcia
Enguita, Francisco J.
dc.subject.por.fl_str_mv Biodegradation
Depolymerizing esterase
Esterase
PETase
Plastic polymer
Polyester
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 12 - Responsible Consumption and Production
SDG 14 - Life Below Water
topic Biodegradation
Depolymerizing esterase
Esterase
PETase
Plastic polymer
Polyester
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 12 - Responsible Consumption and Production
SDG 14 - Life Below Water
description PTDC-MED-GEN-29389-2017
publishDate 2021
dc.date.none.fl_str_mv 2021-12-20T23:16:46Z
2021-03-01
2021-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/129523
url http://hdl.handle.net/10362/129523
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
PURE: 28766656
https://doi.org/10.3390/ijms22052332
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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