BCG vaccine. Its efficacy and impact on the results of tuberculin screening in a high-risk population.
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2364 |
Resumo: | In a housing estate population with a high prevalence of tuberculosis, the authors conducted tuberculosis screening with the tuberculin test, and an investigation with three purposes: evaluation of tuberculosis infection (defined as > 10 mm on tuberculin test), evaluation of BCG effect on tuberculin test, and evaluation of BCG efficacy. The data was collected by nurses during the screening and completed with observation of vaccination records in a health center. The diagnosis of tuberculosis was done by local specialized health services. The statistical significance was tested with Chi Square and Fisher Tests. Vaccine efficacy was calculated on the basis of relative risk of contracting tuberculosis according to vaccination status. The authors tested tuberculin reactivity on 396 persons -53.5% of whole population resident in the neighbourhood. The infection was more prevalent in the 15-44-years-old group (31.2%), in males (25.9%) and black population (30.5%). Only the differences between age groups were statistically significant. After the discussion of probable bias, the authors conclude that BCG does not convert the tuberculin test significantly when the cutpoint is of 10 mm, in a high prevalent tuberculosis population. Therefore, the tuberculin test could be a good diagnostic test for infection, even in vaccinated groups. Lastly, the vaccine efficacy was not confirmed, probably because of the small magnitude of sample size. |
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BCG vaccine. Its efficacy and impact on the results of tuberculin screening in a high-risk population.Vacina BCG. Eficácia e impacto nos resultados de rastreio tuberculínico em população de alto risco.In a housing estate population with a high prevalence of tuberculosis, the authors conducted tuberculosis screening with the tuberculin test, and an investigation with three purposes: evaluation of tuberculosis infection (defined as > 10 mm on tuberculin test), evaluation of BCG effect on tuberculin test, and evaluation of BCG efficacy. The data was collected by nurses during the screening and completed with observation of vaccination records in a health center. The diagnosis of tuberculosis was done by local specialized health services. The statistical significance was tested with Chi Square and Fisher Tests. Vaccine efficacy was calculated on the basis of relative risk of contracting tuberculosis according to vaccination status. The authors tested tuberculin reactivity on 396 persons -53.5% of whole population resident in the neighbourhood. The infection was more prevalent in the 15-44-years-old group (31.2%), in males (25.9%) and black population (30.5%). Only the differences between age groups were statistically significant. After the discussion of probable bias, the authors conclude that BCG does not convert the tuberculin test significantly when the cutpoint is of 10 mm, in a high prevalent tuberculosis population. Therefore, the tuberculin test could be a good diagnostic test for infection, even in vaccinated groups. Lastly, the vaccine efficacy was not confirmed, probably because of the small magnitude of sample size.In a housing estate population with a high prevalence of tuberculosis, the authors conducted tuberculosis screening with the tuberculin test, and an investigation with three purposes: evaluation of tuberculosis infection (defined as > 10 mm on tuberculin test), evaluation of BCG effect on tuberculin test, and evaluation of BCG efficacy. The data was collected by nurses during the screening and completed with observation of vaccination records in a health center. The diagnosis of tuberculosis was done by local specialized health services. The statistical significance was tested with Chi Square and Fisher Tests. Vaccine efficacy was calculated on the basis of relative risk of contracting tuberculosis according to vaccination status. The authors tested tuberculin reactivity on 396 persons -53.5% of whole population resident in the neighbourhood. The infection was more prevalent in the 15-44-years-old group (31.2%), in males (25.9%) and black population (30.5%). Only the differences between age groups were statistically significant. After the discussion of probable bias, the authors conclude that BCG does not convert the tuberculin test significantly when the cutpoint is of 10 mm, in a high prevalent tuberculosis population. Therefore, the tuberculin test could be a good diagnostic test for infection, even in vaccinated groups. Lastly, the vaccine efficacy was not confirmed, probably because of the small magnitude of sample size.Ordem dos Médicos1998-12-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2364oai:ojs.www.actamedicaportuguesa.com:article/2364Acta Médica Portuguesa; Vol. 11 No. 12 (1998): Dezembro; 1073-8Acta Médica Portuguesa; Vol. 11 N.º 12 (1998): Dezembro; 1073-81646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2364https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2364/1782Pina, A Ninfo:eu-repo/semantics/openAccess2022-12-20T11:00:23Zoai:ojs.www.actamedicaportuguesa.com:article/2364Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:17:41.896566Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
BCG vaccine. Its efficacy and impact on the results of tuberculin screening in a high-risk population. Vacina BCG. Eficácia e impacto nos resultados de rastreio tuberculínico em população de alto risco. |
title |
BCG vaccine. Its efficacy and impact on the results of tuberculin screening in a high-risk population. |
spellingShingle |
BCG vaccine. Its efficacy and impact on the results of tuberculin screening in a high-risk population. Pina, A N |
title_short |
BCG vaccine. Its efficacy and impact on the results of tuberculin screening in a high-risk population. |
title_full |
BCG vaccine. Its efficacy and impact on the results of tuberculin screening in a high-risk population. |
title_fullStr |
BCG vaccine. Its efficacy and impact on the results of tuberculin screening in a high-risk population. |
title_full_unstemmed |
BCG vaccine. Its efficacy and impact on the results of tuberculin screening in a high-risk population. |
title_sort |
BCG vaccine. Its efficacy and impact on the results of tuberculin screening in a high-risk population. |
author |
Pina, A N |
author_facet |
Pina, A N |
author_role |
author |
dc.contributor.author.fl_str_mv |
Pina, A N |
description |
In a housing estate population with a high prevalence of tuberculosis, the authors conducted tuberculosis screening with the tuberculin test, and an investigation with three purposes: evaluation of tuberculosis infection (defined as > 10 mm on tuberculin test), evaluation of BCG effect on tuberculin test, and evaluation of BCG efficacy. The data was collected by nurses during the screening and completed with observation of vaccination records in a health center. The diagnosis of tuberculosis was done by local specialized health services. The statistical significance was tested with Chi Square and Fisher Tests. Vaccine efficacy was calculated on the basis of relative risk of contracting tuberculosis according to vaccination status. The authors tested tuberculin reactivity on 396 persons -53.5% of whole population resident in the neighbourhood. The infection was more prevalent in the 15-44-years-old group (31.2%), in males (25.9%) and black population (30.5%). Only the differences between age groups were statistically significant. After the discussion of probable bias, the authors conclude that BCG does not convert the tuberculin test significantly when the cutpoint is of 10 mm, in a high prevalent tuberculosis population. Therefore, the tuberculin test could be a good diagnostic test for infection, even in vaccinated groups. Lastly, the vaccine efficacy was not confirmed, probably because of the small magnitude of sample size. |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-12-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2364 oai:ojs.www.actamedicaportuguesa.com:article/2364 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2364 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/2364 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2364 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2364/1782 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 11 No. 12 (1998): Dezembro; 1073-8 Acta Médica Portuguesa; Vol. 11 N.º 12 (1998): Dezembro; 1073-8 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130630036914176 |