Evaluation of permethrin in rats brains

• Autor(a) principal: Valentini, Francesco
• Data de Publicação: 2016
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.22/18108
• topic: Permethrin; Brains; Rats

Pyrethrins and pyrethroids interfere with the functions of the nervous system. Exposure to very high levels of these substances can cause dizziness, headaches, nausea, muscle spasms, weakness, loss of consciousness and convulsions. There is no evidence that pyrethrins and pyrethroids can affect the reproductive capacity of human beings but some studies have shown reduced fertility in animals. The Occupational Safety and Health Administration (OSHA) has established in 5 milligrams of pyrethrins per cubic meter of air over 40 hours of weekly work, the concentration limit of this substance in the workplace. From this study, it is possible to conclude that is possible to use a methodology to quantify permethrin residues in rats’ brains. It was proved that permethrin can remain in brain during long time. 50% of the rats have permethrin after 24h. The exposition with alkaline water increases the levels of permethrin in brain. By other side, vitamin E, may act as a protecting factor decreasing the levels until not detected.