The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients

Detalhes bibliográficos
Autor(a) principal: Bettencourt, A.
Data de Publicação: 2014
Outros Autores: Martins Silva, A., Carvalho, C., Leal, B., Santos, E., Pinho-Costa, P., Silva, B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/2876
Resumo: Killer Immunoglobulin-like Receptor (KIR) genes may influence both resistance and susceptibility to different autoimmune diseases, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. We investigated the influence of KIR genes on MS susceptibility in 447 MS Portuguese patients, and also whether genetic interactions between specific KIR genes and their HLA class I ligands could contribute to the pathogenesis of MS. Weobserved a negative association between the activating KIR2DS1 gene and MS (adjusted OR = 0.450, p = 0.030)independently from the presence of HLA-DRB1*15 allele. The activating KIR2DS1 receptor seems to confer protection against MS most probably through modulation of autoreactive T cells by Natural Killer cells.
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spelling The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patientsMultiple SclerosisKIRNatural killer CellsPortugalDoenças GenéticasKiller Immunoglobulin-like Receptor (KIR) genes may influence both resistance and susceptibility to different autoimmune diseases, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. We investigated the influence of KIR genes on MS susceptibility in 447 MS Portuguese patients, and also whether genetic interactions between specific KIR genes and their HLA class I ligands could contribute to the pathogenesis of MS. Weobserved a negative association between the activating KIR2DS1 gene and MS (adjusted OR = 0.450, p = 0.030)independently from the presence of HLA-DRB1*15 allele. The activating KIR2DS1 receptor seems to confer protection against MS most probably through modulation of autoreactive T cells by Natural Killer cells.This work was partially supported by Merck Serono Portugal.Elsevier/ International Society for NeuroimmunologyRepositório Científico do Instituto Nacional de SaúdeBettencourt, A.Martins Silva, A.Carvalho, C.Leal, B.Santos, E.Pinho-Costa, P.Silva, B.2015-02-17T15:27:12Z2014-04-152014-04-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/2876engJ Neuroimmunol. 2014 Apr 15;269(1-2):52-5. doi: 10.1016/j.jneuroim.2014.01.009. Epub 2014 Jan 280165-572810.1016/j.jneuroim.2014.01.009info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:31Zoai:repositorio.insa.pt:10400.18/2876Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:37:52.528811Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients
title The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients
spellingShingle The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients
Bettencourt, A.
Multiple Sclerosis
KIR
Natural killer Cells
Portugal
Doenças Genéticas
title_short The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients
title_full The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients
title_fullStr The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients
title_full_unstemmed The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients
title_sort The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients
author Bettencourt, A.
author_facet Bettencourt, A.
Martins Silva, A.
Carvalho, C.
Leal, B.
Santos, E.
Pinho-Costa, P.
Silva, B.
author_role author
author2 Martins Silva, A.
Carvalho, C.
Leal, B.
Santos, E.
Pinho-Costa, P.
Silva, B.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Bettencourt, A.
Martins Silva, A.
Carvalho, C.
Leal, B.
Santos, E.
Pinho-Costa, P.
Silva, B.
dc.subject.por.fl_str_mv Multiple Sclerosis
KIR
Natural killer Cells
Portugal
Doenças Genéticas
topic Multiple Sclerosis
KIR
Natural killer Cells
Portugal
Doenças Genéticas
description Killer Immunoglobulin-like Receptor (KIR) genes may influence both resistance and susceptibility to different autoimmune diseases, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. We investigated the influence of KIR genes on MS susceptibility in 447 MS Portuguese patients, and also whether genetic interactions between specific KIR genes and their HLA class I ligands could contribute to the pathogenesis of MS. Weobserved a negative association between the activating KIR2DS1 gene and MS (adjusted OR = 0.450, p = 0.030)independently from the presence of HLA-DRB1*15 allele. The activating KIR2DS1 receptor seems to confer protection against MS most probably through modulation of autoreactive T cells by Natural Killer cells.
publishDate 2014
dc.date.none.fl_str_mv 2014-04-15
2014-04-15T00:00:00Z
2015-02-17T15:27:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/2876
url http://hdl.handle.net/10400.18/2876
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Neuroimmunol. 2014 Apr 15;269(1-2):52-5. doi: 10.1016/j.jneuroim.2014.01.009. Epub 2014 Jan 28
0165-5728
10.1016/j.jneuroim.2014.01.009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier/ International Society for Neuroimmunology
publisher.none.fl_str_mv Elsevier/ International Society for Neuroimmunology
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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