The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/2876 |
Resumo: | Killer Immunoglobulin-like Receptor (KIR) genes may influence both resistance and susceptibility to different autoimmune diseases, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. We investigated the influence of KIR genes on MS susceptibility in 447 MS Portuguese patients, and also whether genetic interactions between specific KIR genes and their HLA class I ligands could contribute to the pathogenesis of MS. Weobserved a negative association between the activating KIR2DS1 gene and MS (adjusted OR = 0.450, p = 0.030)independently from the presence of HLA-DRB1*15 allele. The activating KIR2DS1 receptor seems to confer protection against MS most probably through modulation of autoreactive T cells by Natural Killer cells. |
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7160 |
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The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patientsMultiple SclerosisKIRNatural killer CellsPortugalDoenças GenéticasKiller Immunoglobulin-like Receptor (KIR) genes may influence both resistance and susceptibility to different autoimmune diseases, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. We investigated the influence of KIR genes on MS susceptibility in 447 MS Portuguese patients, and also whether genetic interactions between specific KIR genes and their HLA class I ligands could contribute to the pathogenesis of MS. Weobserved a negative association between the activating KIR2DS1 gene and MS (adjusted OR = 0.450, p = 0.030)independently from the presence of HLA-DRB1*15 allele. The activating KIR2DS1 receptor seems to confer protection against MS most probably through modulation of autoreactive T cells by Natural Killer cells.This work was partially supported by Merck Serono Portugal.Elsevier/ International Society for NeuroimmunologyRepositório Científico do Instituto Nacional de SaúdeBettencourt, A.Martins Silva, A.Carvalho, C.Leal, B.Santos, E.Pinho-Costa, P.Silva, B.2015-02-17T15:27:12Z2014-04-152014-04-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/2876engJ Neuroimmunol. 2014 Apr 15;269(1-2):52-5. doi: 10.1016/j.jneuroim.2014.01.009. Epub 2014 Jan 280165-572810.1016/j.jneuroim.2014.01.009info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:31Zoai:repositorio.insa.pt:10400.18/2876Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:37:52.528811Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients |
title |
The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients |
spellingShingle |
The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients Bettencourt, A. Multiple Sclerosis KIR Natural killer Cells Portugal Doenças Genéticas |
title_short |
The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients |
title_full |
The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients |
title_fullStr |
The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients |
title_full_unstemmed |
The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients |
title_sort |
The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients |
author |
Bettencourt, A. |
author_facet |
Bettencourt, A. Martins Silva, A. Carvalho, C. Leal, B. Santos, E. Pinho-Costa, P. Silva, B. |
author_role |
author |
author2 |
Martins Silva, A. Carvalho, C. Leal, B. Santos, E. Pinho-Costa, P. Silva, B. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Bettencourt, A. Martins Silva, A. Carvalho, C. Leal, B. Santos, E. Pinho-Costa, P. Silva, B. |
dc.subject.por.fl_str_mv |
Multiple Sclerosis KIR Natural killer Cells Portugal Doenças Genéticas |
topic |
Multiple Sclerosis KIR Natural killer Cells Portugal Doenças Genéticas |
description |
Killer Immunoglobulin-like Receptor (KIR) genes may influence both resistance and susceptibility to different autoimmune diseases, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. We investigated the influence of KIR genes on MS susceptibility in 447 MS Portuguese patients, and also whether genetic interactions between specific KIR genes and their HLA class I ligands could contribute to the pathogenesis of MS. Weobserved a negative association between the activating KIR2DS1 gene and MS (adjusted OR = 0.450, p = 0.030)independently from the presence of HLA-DRB1*15 allele. The activating KIR2DS1 receptor seems to confer protection against MS most probably through modulation of autoreactive T cells by Natural Killer cells. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04-15 2014-04-15T00:00:00Z 2015-02-17T15:27:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/2876 |
url |
http://hdl.handle.net/10400.18/2876 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Neuroimmunol. 2014 Apr 15;269(1-2):52-5. doi: 10.1016/j.jneuroim.2014.01.009. Epub 2014 Jan 28 0165-5728 10.1016/j.jneuroim.2014.01.009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier/ International Society for Neuroimmunology |
publisher.none.fl_str_mv |
Elsevier/ International Society for Neuroimmunology |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132114540560384 |