Ki-67 expression in CRC lymph node metastasis does not predict survival
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/40282 |
Resumo: | Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumourassociated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained byKi-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division. |
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Ki-67 expression in CRC lymph node metastasis does not predict survivalScience & TechnologyColorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumourassociated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained byKi-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division.Hindawi Publishing CorporationUniversidade do MinhoMartins, SandraAmorim, RicardoMota, Sílvia CoelhoCosta, LuísPardal, FernandoRodrigues, MesquitaLongatto Filho, Adhemar20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/40282engMartins, S. F., Amorim, R., Mota, S. C., Costa, L., Pardal, F., Rodrigues, M., & Longatto-Filho, A. (2015). Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival. BioMed Research International, 2015. doi: 10.1155/2015/1316852314-613310.1155/2015/13168526448927http://www.hindawi.com/journals/bmri/aa/131685/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:49:40Zoai:repositorium.sdum.uminho.pt:1822/40282Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:48:12.214858Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Ki-67 expression in CRC lymph node metastasis does not predict survival |
title |
Ki-67 expression in CRC lymph node metastasis does not predict survival |
spellingShingle |
Ki-67 expression in CRC lymph node metastasis does not predict survival Martins, Sandra Science & Technology |
title_short |
Ki-67 expression in CRC lymph node metastasis does not predict survival |
title_full |
Ki-67 expression in CRC lymph node metastasis does not predict survival |
title_fullStr |
Ki-67 expression in CRC lymph node metastasis does not predict survival |
title_full_unstemmed |
Ki-67 expression in CRC lymph node metastasis does not predict survival |
title_sort |
Ki-67 expression in CRC lymph node metastasis does not predict survival |
author |
Martins, Sandra |
author_facet |
Martins, Sandra Amorim, Ricardo Mota, Sílvia Coelho Costa, Luís Pardal, Fernando Rodrigues, Mesquita Longatto Filho, Adhemar |
author_role |
author |
author2 |
Amorim, Ricardo Mota, Sílvia Coelho Costa, Luís Pardal, Fernando Rodrigues, Mesquita Longatto Filho, Adhemar |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Martins, Sandra Amorim, Ricardo Mota, Sílvia Coelho Costa, Luís Pardal, Fernando Rodrigues, Mesquita Longatto Filho, Adhemar |
dc.subject.por.fl_str_mv |
Science & Technology |
topic |
Science & Technology |
description |
Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumourassociated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained byKi-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/40282 |
url |
http://hdl.handle.net/1822/40282 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Martins, S. F., Amorim, R., Mota, S. C., Costa, L., Pardal, F., Rodrigues, M., & Longatto-Filho, A. (2015). Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival. BioMed Research International, 2015. doi: 10.1155/2015/131685 2314-6133 10.1155/2015/131685 26448927 http://www.hindawi.com/journals/bmri/aa/131685/ |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133059275030528 |