Ki-67 expression in CRC lymph node metastasis does not predict survival

Detalhes bibliográficos
Autor(a) principal: Martins, Sandra
Data de Publicação: 2015
Outros Autores: Amorim, Ricardo, Mota, Sílvia Coelho, Costa, Luís, Pardal, Fernando, Rodrigues, Mesquita, Longatto Filho, Adhemar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/40282
Resumo: Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumourassociated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained byKi-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division.
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spelling Ki-67 expression in CRC lymph node metastasis does not predict survivalScience & TechnologyColorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumourassociated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained byKi-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division.Hindawi Publishing CorporationUniversidade do MinhoMartins, SandraAmorim, RicardoMota, Sílvia CoelhoCosta, LuísPardal, FernandoRodrigues, MesquitaLongatto Filho, Adhemar20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/40282engMartins, S. F., Amorim, R., Mota, S. C., Costa, L., Pardal, F., Rodrigues, M., & Longatto-Filho, A. (2015). Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival. BioMed Research International, 2015. doi: 10.1155/2015/1316852314-613310.1155/2015/13168526448927http://www.hindawi.com/journals/bmri/aa/131685/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:49:40Zoai:repositorium.sdum.uminho.pt:1822/40282Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:48:12.214858Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Ki-67 expression in CRC lymph node metastasis does not predict survival
title Ki-67 expression in CRC lymph node metastasis does not predict survival
spellingShingle Ki-67 expression in CRC lymph node metastasis does not predict survival
Martins, Sandra
Science & Technology
title_short Ki-67 expression in CRC lymph node metastasis does not predict survival
title_full Ki-67 expression in CRC lymph node metastasis does not predict survival
title_fullStr Ki-67 expression in CRC lymph node metastasis does not predict survival
title_full_unstemmed Ki-67 expression in CRC lymph node metastasis does not predict survival
title_sort Ki-67 expression in CRC lymph node metastasis does not predict survival
author Martins, Sandra
author_facet Martins, Sandra
Amorim, Ricardo
Mota, Sílvia Coelho
Costa, Luís
Pardal, Fernando
Rodrigues, Mesquita
Longatto Filho, Adhemar
author_role author
author2 Amorim, Ricardo
Mota, Sílvia Coelho
Costa, Luís
Pardal, Fernando
Rodrigues, Mesquita
Longatto Filho, Adhemar
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Martins, Sandra
Amorim, Ricardo
Mota, Sílvia Coelho
Costa, Luís
Pardal, Fernando
Rodrigues, Mesquita
Longatto Filho, Adhemar
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumourassociated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained byKi-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/40282
url http://hdl.handle.net/1822/40282
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Martins, S. F., Amorim, R., Mota, S. C., Costa, L., Pardal, F., Rodrigues, M., & Longatto-Filho, A. (2015). Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival. BioMed Research International, 2015. doi: 10.1155/2015/131685
2314-6133
10.1155/2015/131685
26448927
http://www.hindawi.com/journals/bmri/aa/131685/
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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