Chitosan/alginate based multilayers to control drug release fromophthalmic lens
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/20035 |
Resumo: | In this study we investigated the possibility of using layer-by-layer deposition, based in natural polymers (chitosan and alginate), to control the release of different ophthalmic drugs from three types of lens materials: a silicone-based hydrogel recently proposed by our group as drug releasing soft contact lens (SCL) material and two commercially available materials: CI26Y for intraocular lens (IOLs) and Definitive 50 for SCLs. The optimised coating, consisting in one double layer of (alginate – CaCl2)/(chitosan + glyoxal) topped with a final alginate-CaCl2 layer to avoid chitosan degradation by tear fluid proteins, proved to have excellent features to control the release of the anti-inflammatory, diclofenac, while keeping or improving the physical properties of the lenses. The coating leads to a controlled release of diclofenac from SCL and IOL materials for, at least, one week. Due to its high hydrophilicity (water contact angle ≈ 0) and biocompatibility, it should avoid the use of further surface treatments to enhance the useŕs comfort. However, the barrier effect of this coating is specific for diclofenac, giving evidence to the need of optimizing the chemical composition of the layers in view of the desired drug. |
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Chitosan/alginate based multilayers to control drug release fromophthalmic lensControlled drug releaseOphthalmic lensLayer-by-layer coatingsAlginateChitosanIn this study we investigated the possibility of using layer-by-layer deposition, based in natural polymers (chitosan and alginate), to control the release of different ophthalmic drugs from three types of lens materials: a silicone-based hydrogel recently proposed by our group as drug releasing soft contact lens (SCL) material and two commercially available materials: CI26Y for intraocular lens (IOLs) and Definitive 50 for SCLs. The optimised coating, consisting in one double layer of (alginate – CaCl2)/(chitosan + glyoxal) topped with a final alginate-CaCl2 layer to avoid chitosan degradation by tear fluid proteins, proved to have excellent features to control the release of the anti-inflammatory, diclofenac, while keeping or improving the physical properties of the lenses. The coating leads to a controlled release of diclofenac from SCL and IOL materials for, at least, one week. Due to its high hydrophilicity (water contact angle ≈ 0) and biocompatibility, it should avoid the use of further surface treatments to enhance the useŕs comfort. However, the barrier effect of this coating is specific for diclofenac, giving evidence to the need of optimizing the chemical composition of the layers in view of the desired drug.ElsevierRepositório ComumSilva, DianaPinto, Luís F. V.Bozukova, DimitriyaSantos, Luís F.Serro, Ana PaulaSaramago, Benilde2018-01-10T12:41:37Z2016-11-01T00:00:00Z2016-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/20035engDiana Silva, Luís F.V. Pinto, Dimitriya Bozukova, Luís F. Santos, Ana Paula Serro, Benilde Saramago, Chitosan/alginate based multilayers to control drug release from ophthalmic lens, Colloids and Surfaces B: Biointerfaces, Volume 147, 2016, Pages 81-89, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2016.07.047.0927-776510.1016/j.colsurfb.2016.07.047info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:13Zoai:comum.rcaap.pt:10400.26/20035Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:08.776051Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Chitosan/alginate based multilayers to control drug release fromophthalmic lens |
title |
Chitosan/alginate based multilayers to control drug release fromophthalmic lens |
spellingShingle |
Chitosan/alginate based multilayers to control drug release fromophthalmic lens Silva, Diana Controlled drug release Ophthalmic lens Layer-by-layer coatings Alginate Chitosan |
title_short |
Chitosan/alginate based multilayers to control drug release fromophthalmic lens |
title_full |
Chitosan/alginate based multilayers to control drug release fromophthalmic lens |
title_fullStr |
Chitosan/alginate based multilayers to control drug release fromophthalmic lens |
title_full_unstemmed |
Chitosan/alginate based multilayers to control drug release fromophthalmic lens |
title_sort |
Chitosan/alginate based multilayers to control drug release fromophthalmic lens |
author |
Silva, Diana |
author_facet |
Silva, Diana Pinto, Luís F. V. Bozukova, Dimitriya Santos, Luís F. Serro, Ana Paula Saramago, Benilde |
author_role |
author |
author2 |
Pinto, Luís F. V. Bozukova, Dimitriya Santos, Luís F. Serro, Ana Paula Saramago, Benilde |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Comum |
dc.contributor.author.fl_str_mv |
Silva, Diana Pinto, Luís F. V. Bozukova, Dimitriya Santos, Luís F. Serro, Ana Paula Saramago, Benilde |
dc.subject.por.fl_str_mv |
Controlled drug release Ophthalmic lens Layer-by-layer coatings Alginate Chitosan |
topic |
Controlled drug release Ophthalmic lens Layer-by-layer coatings Alginate Chitosan |
description |
In this study we investigated the possibility of using layer-by-layer deposition, based in natural polymers (chitosan and alginate), to control the release of different ophthalmic drugs from three types of lens materials: a silicone-based hydrogel recently proposed by our group as drug releasing soft contact lens (SCL) material and two commercially available materials: CI26Y for intraocular lens (IOLs) and Definitive 50 for SCLs. The optimised coating, consisting in one double layer of (alginate – CaCl2)/(chitosan + glyoxal) topped with a final alginate-CaCl2 layer to avoid chitosan degradation by tear fluid proteins, proved to have excellent features to control the release of the anti-inflammatory, diclofenac, while keeping or improving the physical properties of the lenses. The coating leads to a controlled release of diclofenac from SCL and IOL materials for, at least, one week. Due to its high hydrophilicity (water contact angle ≈ 0) and biocompatibility, it should avoid the use of further surface treatments to enhance the useŕs comfort. However, the barrier effect of this coating is specific for diclofenac, giving evidence to the need of optimizing the chemical composition of the layers in view of the desired drug. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-11-01T00:00:00Z 2016-11-01T00:00:00Z 2018-01-10T12:41:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/20035 |
url |
http://hdl.handle.net/10400.26/20035 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Diana Silva, Luís F.V. Pinto, Dimitriya Bozukova, Luís F. Santos, Ana Paula Serro, Benilde Saramago, Chitosan/alginate based multilayers to control drug release from ophthalmic lens, Colloids and Surfaces B: Biointerfaces, Volume 147, 2016, Pages 81-89, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2016.07.047. 0927-7765 10.1016/j.colsurfb.2016.07.047 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799129960337637376 |