Chitosan/alginate based multilayers to control drug release fromophthalmic lens

Detalhes bibliográficos
Autor(a) principal: Silva, Diana
Data de Publicação: 2016
Outros Autores: Pinto, Luís F. V., Bozukova, Dimitriya, Santos, Luís F., Serro, Ana Paula, Saramago, Benilde
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/20035
Resumo: In this study we investigated the possibility of using layer-by-layer deposition, based in natural polymers (chitosan and alginate), to control the release of different ophthalmic drugs from three types of lens materials: a silicone-based hydrogel recently proposed by our group as drug releasing soft contact lens (SCL) material and two commercially available materials: CI26Y for intraocular lens (IOLs) and Definitive 50 for SCLs. The optimised coating, consisting in one double layer of (alginate – CaCl2)/(chitosan + glyoxal) topped with a final alginate-CaCl2 layer to avoid chitosan degradation by tear fluid proteins, proved to have excellent features to control the release of the anti-inflammatory, diclofenac, while keeping or improving the physical properties of the lenses. The coating leads to a controlled release of diclofenac from SCL and IOL materials for, at least, one week. Due to its high hydrophilicity (water contact angle ≈ 0) and biocompatibility, it should avoid the use of further surface treatments to enhance the useŕs comfort. However, the barrier effect of this coating is specific for diclofenac, giving evidence to the need of optimizing the chemical composition of the layers in view of the desired drug.
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spelling Chitosan/alginate based multilayers to control drug release fromophthalmic lensControlled drug releaseOphthalmic lensLayer-by-layer coatingsAlginateChitosanIn this study we investigated the possibility of using layer-by-layer deposition, based in natural polymers (chitosan and alginate), to control the release of different ophthalmic drugs from three types of lens materials: a silicone-based hydrogel recently proposed by our group as drug releasing soft contact lens (SCL) material and two commercially available materials: CI26Y for intraocular lens (IOLs) and Definitive 50 for SCLs. The optimised coating, consisting in one double layer of (alginate – CaCl2)/(chitosan + glyoxal) topped with a final alginate-CaCl2 layer to avoid chitosan degradation by tear fluid proteins, proved to have excellent features to control the release of the anti-inflammatory, diclofenac, while keeping or improving the physical properties of the lenses. The coating leads to a controlled release of diclofenac from SCL and IOL materials for, at least, one week. Due to its high hydrophilicity (water contact angle ≈ 0) and biocompatibility, it should avoid the use of further surface treatments to enhance the useŕs comfort. However, the barrier effect of this coating is specific for diclofenac, giving evidence to the need of optimizing the chemical composition of the layers in view of the desired drug.ElsevierRepositório ComumSilva, DianaPinto, Luís F. V.Bozukova, DimitriyaSantos, Luís F.Serro, Ana PaulaSaramago, Benilde2018-01-10T12:41:37Z2016-11-01T00:00:00Z2016-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/20035engDiana Silva, Luís F.V. Pinto, Dimitriya Bozukova, Luís F. Santos, Ana Paula Serro, Benilde Saramago, Chitosan/alginate based multilayers to control drug release from ophthalmic lens, Colloids and Surfaces B: Biointerfaces, Volume 147, 2016, Pages 81-89, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2016.07.047.0927-776510.1016/j.colsurfb.2016.07.047info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:13Zoai:comum.rcaap.pt:10400.26/20035Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:08.776051Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chitosan/alginate based multilayers to control drug release fromophthalmic lens
title Chitosan/alginate based multilayers to control drug release fromophthalmic lens
spellingShingle Chitosan/alginate based multilayers to control drug release fromophthalmic lens
Silva, Diana
Controlled drug release
Ophthalmic lens
Layer-by-layer coatings
Alginate
Chitosan
title_short Chitosan/alginate based multilayers to control drug release fromophthalmic lens
title_full Chitosan/alginate based multilayers to control drug release fromophthalmic lens
title_fullStr Chitosan/alginate based multilayers to control drug release fromophthalmic lens
title_full_unstemmed Chitosan/alginate based multilayers to control drug release fromophthalmic lens
title_sort Chitosan/alginate based multilayers to control drug release fromophthalmic lens
author Silva, Diana
author_facet Silva, Diana
Pinto, Luís F. V.
Bozukova, Dimitriya
Santos, Luís F.
Serro, Ana Paula
Saramago, Benilde
author_role author
author2 Pinto, Luís F. V.
Bozukova, Dimitriya
Santos, Luís F.
Serro, Ana Paula
Saramago, Benilde
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Silva, Diana
Pinto, Luís F. V.
Bozukova, Dimitriya
Santos, Luís F.
Serro, Ana Paula
Saramago, Benilde
dc.subject.por.fl_str_mv Controlled drug release
Ophthalmic lens
Layer-by-layer coatings
Alginate
Chitosan
topic Controlled drug release
Ophthalmic lens
Layer-by-layer coatings
Alginate
Chitosan
description In this study we investigated the possibility of using layer-by-layer deposition, based in natural polymers (chitosan and alginate), to control the release of different ophthalmic drugs from three types of lens materials: a silicone-based hydrogel recently proposed by our group as drug releasing soft contact lens (SCL) material and two commercially available materials: CI26Y for intraocular lens (IOLs) and Definitive 50 for SCLs. The optimised coating, consisting in one double layer of (alginate – CaCl2)/(chitosan + glyoxal) topped with a final alginate-CaCl2 layer to avoid chitosan degradation by tear fluid proteins, proved to have excellent features to control the release of the anti-inflammatory, diclofenac, while keeping or improving the physical properties of the lenses. The coating leads to a controlled release of diclofenac from SCL and IOL materials for, at least, one week. Due to its high hydrophilicity (water contact angle ≈ 0) and biocompatibility, it should avoid the use of further surface treatments to enhance the useŕs comfort. However, the barrier effect of this coating is specific for diclofenac, giving evidence to the need of optimizing the chemical composition of the layers in view of the desired drug.
publishDate 2016
dc.date.none.fl_str_mv 2016-11-01T00:00:00Z
2016-11-01T00:00:00Z
2018-01-10T12:41:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/20035
url http://hdl.handle.net/10400.26/20035
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Diana Silva, Luís F.V. Pinto, Dimitriya Bozukova, Luís F. Santos, Ana Paula Serro, Benilde Saramago, Chitosan/alginate based multilayers to control drug release from ophthalmic lens, Colloids and Surfaces B: Biointerfaces, Volume 147, 2016, Pages 81-89, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2016.07.047.
0927-7765
10.1016/j.colsurfb.2016.07.047
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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