Mineral and Bone Disease (MBD)

• Autor(a) principal: Birne,Rita
• Data de Publicação: 2014
• Outros Autores: Adragão,Teresa, Ferreira,Aníbal, Dickson,Jorge, Silva,Rui, Casqueiro,Ana, Oliveira,Regina, Martins,Ana Rita, Torres,João, Matias,Patrícia, Branco,Patrícia, Jorge,Cristina, Weigert,André, Bruges,Margarida, Machado,Domingos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692014000100010
• topic: Bone biopsy; cinacalcet; ckd-mbd; hypercalcaemia; kidney transplantation; osteoporosis

A 50-year-old post-menopausal recipient of a kidney allograft with bone pain, osteoporosis, persistent hypercalcaemia and elevated parathormone (PTH) levels, despite a satisfactory graft function, was treated with bisphosphonates and cinacalcet starting, respectively, 5 and 6 months after renal transplantation (RT). Sixteen months after treatment, there was improvement of bone mineral density (BMD) measured by dualenergy X-ray absorptiometry (DEXA). A bone biopsy was taken, unveiling a surprising and worrisome result. Post-RT bone disease is different from classic CKD-MBD and should be managed distinctly, including, in some difficult cases, an invasive evaluation through the performance of a bone biopsy, as suggested in the KDIGO guidelines.